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  1. Desmopressin acetate (DPA) is a synthetic analogue of vasopressin used in the treatment of diabetes insipidus, bedwetting, hemophilia A, and elevated levels of urea in the blood. Sensitive and selective stabil...

    Authors: Khadiga M. Kelani, Ahmed M. Wafaa Nassar, Gamal A. Omran, Samir Morshedy and Wael Talaat
    Citation: BMC Chemistry 2022 16:117
  2. The discoveries recommend that the photoinduced conditions of fluorescein-determined go about as impetus for photochemically combining polysubstituted quinolines in ethanol at room temperature under air enviro...

    Authors: Farzaneh Mohamadpour
    Citation: BMC Chemistry 2022 16:116
  3. A simple and precise analytical approach developed for single and simultaneous determination of resorcinol (RC) and hydroquinone (HQ) in pharmaceutical samples using carbon paste electrode (CPE) modified with ...

    Authors: Ebrahim Nabatian, Mahdi Mousavi, Mostafa Pournamdari, Mehdi Yoosefian and Saeid Ahmadzadeh
    Citation: BMC Chemistry 2022 16:115
  4. An isocratic RP-HPLC method has been developed for the separation and determination of methocarbamol (MTL), indomethacin (IND), and betamethasone (BET) in combined dosage form using an Inertsil ODS-3v C18 (250...

    Authors: Ehab F. Elkady, Marwa A. Fouad and Ayoub N. Mozayad
    Citation: BMC Chemistry 2022 16:114
  5. In this study, we have used hydroxyethyl cellulose (HEC) to prepare antimicrobial films for multipurpose applications. Using HEC gives mangiferin powder (M) mechanical properties, while mangiferin powder gives...

    Authors: Hebat-Allah S. Tohamy, Mohamed El-Sakhawy, Hossam M. El-Masry, Ibrahim A. Saleh and Mona M. AbdelMohsen
    Citation: BMC Chemistry 2022 16:113
  6. Ludwigia adscendens subsp. diffusa (Onagraceae), an important aquatic herb widely distributed in the Nile River and canals in Egypt. The goal of the current study is to investigate the phytochemical composition o...

    Authors: Mostafa H. Baky, Mohamed R. Elgindi, Enas M. Shawky and Haitham A. Ibrahim
    Citation: BMC Chemistry 2022 16:112
  7. Quinolone is a privileged scaffold in medicinal chemistry and 4-Quinolone-3-Carboxamides have been reported to harbor vast therapeutic potential. However, conversion of N-1 substituted 4-Quinolone 3-Carboxylat...

    Authors: Muhammad Shoaib Ali Gill, Nursyuhada Azzman, Sharifah Syed Hassan, Syed Adnan Ali Shah and Nafees Ahemad
    Citation: BMC Chemistry 2022 16:111
  8. In the present study, a green surface modification of gold nanoparticles (GNPs) using chondroitin sulfate (CHS) and chitosan (CS) to deliver an extended-release of doxorubicin (DOX) was proposed. Following syn...

    Authors: Maryam Asariha, Seyed Hossein Kiaie, Sepideh Izadi, Faezeh H. Pirhayati, Mehdi Fouladi and Maryam Gholamhosseinpour
    Citation: BMC Chemistry 2022 16:110
  9. This research work focuses on the synthesis, characterization through spectra (FT-IR, UV–vis, and 1H-NMR) investigations, and the use of density functional theory (DFT) along with time-dependent density functiona...

    Authors: Mbang I. Ofem, Hitler Louis, John A. Agwupuye, Umar S. Ameuru, Gloria C. Apebende, Terkumbur E. Gber, Joseph O. Odey, Neksumi Musa and Ayi A. Ayi
    Citation: BMC Chemistry 2022 16:109
  10. Etoricoxib (ETO), Paracetamol (PCM), and two toxic impurities for Paracetamol impurity K (4-aminophenol (PAP)) and impurity E (para-hydroxy acetophenone (PHA)) were separated using a simple and selective HPLC ...

    Authors: Mona A. Abdel Rahman, Mohamed R. Elghobashy, Hala E. Zaazaa, Shimaa A. Atty and Sally S. El-Mosallamy
    Citation: BMC Chemistry 2022 16:108
  11. Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted-4(3H)-quinazolinones were synt...

    Authors: Girma Worku Seifu, Yihenew Simegniew Birhan, Botros Youssef Beshay, Ariaya Hymete and Adnan Ahmed Bekhit
    Citation: BMC Chemistry 2022 16:107
  12. In this study, the ethyl acetate fraction of Myristica fragrans Houtt. was investigated for its in vitro anticholinesterase activity as well as neuroprotectivity against H2O2-induced cell death in PC12 neuronal c...

    Authors: Arezoo Rastegari, Azadeh Manayi, Mahdi Rezakazemi, Mahdieh Eftekhari, Mahnaz Khanavi, Tahmineh Akbarzadeh and Mina Saeedi
    Citation: BMC Chemistry 2022 16:106
  13. In this work, nickel oxide nanoparticles were prepared by polyol mediated aqueous route of sol–gel process using nickel nitrate hexahydrate as precursor, a mixture of isopropyl alcohol and water as solvent and...

    Authors: Samreen Zahra, Waneeza Shahid, Chaudhry Athar Amin, Sarwat Zahra and Bushra Kanwal
    Citation: BMC Chemistry 2022 16:105
  14. A new series of (E)-2-(3-(substitutedstyryl)-5-(substitutedphenyl)-4,5-dihydropyrazol-1-yl)benzo[d]thiazole derivatives was synthesized and the chemical structures of synthesized compounds were deduced by IR and ...

    Authors: Manoj Kumar, Vijay Kumar, Vikramjeet Singh and Samridhi Thakral
    Citation: BMC Chemistry 2022 16:103
  15. A precise, sensitive eco-friendly, simple, rapid, and derivative spectrofluorimetric method was developed to quantify edoxaban tosylate monohydrate in pure form and pharmaceutical dosage form. Sudden death due...

    Authors: Mohamed Rizk, Maha Mahmoud Abou El-Alamin, Ola Abd Elkhalek and Aliaa I. Shallan
    Citation: BMC Chemistry 2022 16:102
  16. Turkevich gold nanospheres are the original nanospheres that have been modified over time. Its combination with targeting medications such as alendronate, memantine, and tobramycin will provide additional bene...

    Authors: Dina M. Eissa, Mokhtar M. Mabrouk, El Zeiny M. Ebeid and Mohamed A. Abdel Hamid
    Citation: BMC Chemistry 2022 16:101
  17. A series of quinazolinone derivatives (7a7h) were synthesized as antiproliferative agents. All compounds, were synthesized through three steps method and structurally evaluated by FTIR, 1H-NMR, 13CNMR and Mass s...

    Authors: Leila Emami, Soghra Khabnadideh, Zahra Faghih, Farnoosh Farahvasi, Fatemeh Zonobi, Saman Zare Gheshlaghi, Shadi Daili, Ali Ebrahimi and Zeinab Faghih
    Citation: BMC Chemistry 2022 16:100
  18. A validated, sensitive, and simple spectrofluorimetric method was developed for the analysis of two important CNS-acting drugs, olanzapine and diazepam, in their commercial tablets without the need for any pre...

    Authors: Galal Magdy, Noura Said, Ramadan A. El-Domany and Fathalla Belal
    Citation: BMC Chemistry 2022 16:98
  19. The development of new antidiabetes agents is necessary to obtain optimal glycemic control and overcome its complications. Different quinazolin-4(3H)-one bearing phenoxy-acetamide derivatives (7a–r) were designed...

    Authors: Mahshid Moheb, Aida Iraji, Navid Dastyafteh, Minoo Khalili Ghomi, Milad Noori, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fatemeh Rasekh, Bagher Larijani, Kamiar Zomorodian, Seyed Esmaeil Sadat-Ebrahimi and Mohammad Mahdavi
    Citation: BMC Chemistry 2022 16:97
  20. Isodon amethystoides (Lamiaceae) is a popular plant in folk medicine in the southern provinces of China. Our phytochemical investigation of the twigs and leaves of this plant led to the discovery of five new dite...

    Authors: Chenliang Zhao, Lang Zhou, Wenjian Xie, Lihan Zhao, Chiyuan Zhang, Kang He, Jianghai Ye, Jingjie Zhang, Lutai Pan, Juan Zou and Hongjie Zhang
    Citation: BMC Chemistry 2022 16:96
  21. Free doxorubicin (Dox) is used as a chemotherapeutic agent against hepatocellular carcinoma (HCC), but it results in cardiotoxicty as a major side effect. Hence, a controlled Dox drug delivery system is extrem...

    Authors: Abdelgawad Fahmi, Mariam Abdur-Rahman, Omnia Mahareek and Mohamed A. shemis
    Citation: BMC Chemistry 2022 16:95
  22. As a promising strategy to overcome the therapeutic disadvantages of 6-mercaptopurine (6MP), we proposed the encapsulation of 6MP in chitosan nanoparticles (CNPs) to form the 6MP-CNPs complexes. The encapsulat...

    Authors: Amna H. Faid, Samia A. Shouman, Yehia A. Badr, Marwa Sharaky, Elham M. Mostafa and Mahmoud A. Sliem
    Citation: BMC Chemistry 2022 16:94
  23. Metal organic frameworks (MOFs) have received a lot of attention in the research community due to their unique physical properties, which make them ideal materials for targeted drug delivery systems. In this p...

    Authors: Moosareza Safinejad, Amir Rigi, Malihe Zeraati, Zohreh Heidary, Shohreh Jahani, Narendra Pal Singh Chauhan and Ghasem Sargazi
    Citation: BMC Chemistry 2022 16:93
  24. Electrophoretic deposition (EPD) coating has become a hot topic due to its simple experiment, wide application, and wide material range. In this study, the PTFE coating was successfully prepared by electrophor...

    Authors: Qing Xiang, Jiyao Qin, Taihong Qin, Lu Chen and Daixiong Zhang
    Citation: BMC Chemistry 2022 16:92
  25. Herein, we reported the synthesis of nineteen novel 1,2,4-triazole derivatives including 1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl) propan-1-ones (7a-e), 1-(1,3-diphenylpropan-2-yl)-1H-1,2,4-triazole (8a-c) and 1,4-d...

    Authors: Leila Emami, Sara Sadeghian, Ayyub Mojaddami, Soghra khabnadideh, Amirhossein Sakhteman, Hossein Sadeghpour, Zeinab Faghih, Masood Fereidoonnezhad and Zahra Rezaei
    Citation: BMC Chemistry 2022 16:91
  26. Researchers seeking for green chemistry to help safeguard and boost the economy and the environment by discovering unique ways to decrease waste and find substitutes for dangerous chemicals. In this study, a g...

    Authors: Mohamed Rizk, Emad M. Hussein, Safaa Toubar, Emad Ramzy and Marwa I. Helmy
    Citation: BMC Chemistry 2022 16:89
  27. A new series of pyridine, thiazole, and pyrazole analogues were synthesized. The pyridone analogues 4a-e were synthesized by treating N-aryl-2-cyano-3-(4-(diphenylamino)phenyl)acrylamides 3a-e with malononitrile....

    Authors: Mohamed R. Elmorsy, Samar E. Mahmoud, Ahmed A. Fadda, Ehab Abdel-Latif and Miral A. Abdelmoaz
    Citation: BMC Chemistry 2022 16:88
  28. Honey is a natural, sugary and sticky liquid that is produced from the nectars of flowers by the bees. This study aimed to analyze the concentration of some selected heavy Metals in honey samples. 1 g of honey...

    Authors: Dessie Tibebe, Mohammed Hussen, Marye Mulugeta, Dereje yenealem, Zerubabile Moges, Mohammed Gedefaw and Yezbie Kassa
    Citation: BMC Chemistry 2022 16:87
  29. Zinc-Imidazole coordination polymer (ZnImCP) was simply synthesized hydrothermally at relatively low temperature (70 °C) from zinc acetate and imidazole. ZnImCP was treated by sulfide solution to produce sulfu...

    Authors: Mostafa Mohsen, Ahmad Baraka, Ibrahim Naeem, Hesham Tantawy, Mohamed Awaad and Osama Abuzalat
    Citation: BMC Chemistry 2022 16:86
  30. Quinolone and sulfonamide are two classes of antibacterial agents with an opulent history of medicinal chemistry features that contribute to their bacterial spectrum, efficacy, pharmacokinetics, and adverse ef...

    Authors: Marwa A. Fouad, Ahmed Serag, Enas H. Tolba, Manal A. El-Shal and Ahmed M. El Kerdawy
    Citation: BMC Chemistry 2022 16:85
  31. A series of coumarin-indole hybrids was synthesized as the new α-glucosidase inhibitors. The title hybrids were considered as α-glucosidase inhibitors because had two active pharmacophores against α-glucosidas...

    Authors: Davood Rezapour Niri, Mohammad Hosein Sayahi, Somayeh Behrouz, Ali Moazzam, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Hossein Rastegar, Maryam Mohammadi-Khanaposhtani and Mohammad Mahdavi
    Citation: BMC Chemistry 2022 16:84
  32. N7-(2-carbamoyl-2-hydroxyethyl)guanine (N7-CAG) is a DNA adduct formed by glycidamide, which is the metabolite of acrylamide. Acrylamide can be found in foods containing reducing sugars and asparagine that are h....

    Authors: Yahdiana Harahap, Winning Bekti Safitri and Sunarsih Sunarsih
    Citation: BMC Chemistry 2022 16:83
  33. Computational tools in investigating of spectral heterocyclic compounds ranges based on pyrimidine‑2‑thiones, take some importance in identifying their molecular and electronic behavior. Some charcoal heterocy...

    Authors: Doaa S. El Sayed and El-Sayed M. Abdelrehim
    Citation: BMC Chemistry 2022 16:82
  34. Compounds possessing urea/thiourea moiety have a wide range of biological properties including anticancer activity. On the other hand, taking advantage of the low toxicity and structural diversity of hydrazone...

    Authors: Nasrin Nassiri Koopaei, Mehrasa Shademani, Nasrin Shirzad Yazdi, Raheleh Tahmasvand, Mina Dehbid, Mansur Nassiri Koopaei, Homa Azizian, Zahra Mousavi, Ali Almasirad and Mona Salimi
    Citation: BMC Chemistry 2022 16:81
  35. A highly sensitive spectrofluorimetric method is developed for the determination of prucalopride succinate (PRU). The method depends on lanthanide-sensitized luminescence due to complex formation between the d...

    Authors: Mona S. Elshahed, Safaa S. Toubar, Azza A. Ashour and Rasha Th. El-Eryan
    Citation: BMC Chemistry 2022 16:80
  36. Modafinil (MDF) is one of the neurostimulants with a potential effect in the COVID-19 ICU ventilated patients and post-COVID neurological syndrome treatment. Four rapid, simple and cost-effective stability ind...

    Authors: Soha G. Elsheikh, Sally S. El-Mosallamy, Yasmin M. Fayez and Abeer M. E. Hassan
    Citation: BMC Chemistry 2022 16:79
  37. The experimental design extracts valuable information about the main effects and interactions from the least number of experiments. The current work constructs a solid-state sensor for selective assay of Ondan...

    Authors: Mona A. Abdel Rahman, Shimaa A. Atty, Sally S. El-Mosallamy, Mohamed R. Elghobashy, Hala E. Zaazaa and Ahmed S. Saad
    Citation: BMC Chemistry 2022 16:77
  38. Bryophytes have a variety of bioactive compounds that can be used in biotechnological processes. The objective of this study was to know the volatile chemical composition of Octoblepharum albidum Hedw. from the A...

    Authors: Raynon Joel Monteiro Alves, Thyago Gonçalves Miranda, Rafaela Oliveira Pinheiro, Wandson Braamcamp de Souza Pinheiro, Eloisa Helena de Aguiar Andrade and Ana Cláudia Caldeira Tavares-Martins
    Citation: BMC Chemistry 2022 16:76
  39. Deregulation of NEK2(NIMA-related serine/threonine 2) confers chemotherapeutic resistance to apoptosis and is closely correlated with poor prognosis in hepatocellular carcinoma (HCC). Here, we find that nanopa...

    Authors: Danni Li, Jiahao Lu, Qiying Zhang, Yuzhu Zhou, Long Li, Hua Zhu and Tong Li
    Citation: BMC Chemistry 2022 16:75
  40. The photocatalytic degradation (PCD) of ethanol in an inert atmosphere on catalysis was explored in a lab-scale experiment. A morphologically tuned nanostructured controlled ZnO and ZnO/TiO2 nanocomposites were s...

    Authors: Omar Mbrouk, H. Hafez, Sylwia Mozia, A. M. Othman and M. S. A. Abdel Mottaleb
    Citation: BMC Chemistry 2022 16:74
  41. Currently, all researchers are concentrating their efforts on countering the COVID-19 pandemic. The majority of patients are managed at home, according to recent statistics. An OTC triple action combination co...

    Authors: Hoda M. Marzouk, Engy A. Ibrahim, Maha A. Hegazy and Samah S. Saad
    Citation: BMC Chemistry 2022 16:73
  42. Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutica...

    Authors: Hany Ibrahim, Omar M El-Abassy, Hisham Ezzat Abdellatef, Hassan A. M. Hendawy and Heba M El-Sayed
    Citation: BMC Chemistry 2022 16:72
  43. Cabergoline (CAB) is effective prolactin lowering drug. Evaluation of the bioequivalence for the new test product (0.5 mg CAB film-coated tablets) in Egypt is strongly needed for approval of the drug by the of...

    Authors: Khaled Shalaby, Saleh Alghamdi, Mohammed Gamal, Lobna Mohammed Abd Elhalim and Rehab Moussa Tony
    Citation: BMC Chemistry 2022 16:71
  44. A new rapid, simple, and sensitive RP-HPLC method was carried out through applying Quality by Design approach for determination of xipamide and valsartan in Human plasma. Fractional factorial design was used f...

    Authors: Mahmoud M. Sebaiy, Sobhy M. El-Adl, Mohamed M. Baraka, Amira A. Hassan and Heba M. El-Sayed
    Citation: BMC Chemistry 2022 16:70
  45. The deficiency of vitamin B2 can lead to many health problems. Therefore, it is necessary to develop a sensitive, selective and fast method for the determination of vitamin B2 in food samples. In this work, a ...

    Authors: Gizaw Tesfaye, Negussie Negash and Merid Tessema
    Citation: BMC Chemistry 2022 16:69
  46. Nowadays, there are more than fourteen major state and private owned textile industries and garment factories in Ethiopia. However, these textile effluents are directly discharged without treatment to the surr...

    Authors: Dessie Tibebe, Almaz Negash, Marye Mulugeta, Yezbie Kassa, Zerubabel Moges and Dereje Yenealem
    Citation: BMC Chemistry 2022 16:67

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