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  1. Content type: Research article

    The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD)...

    Authors: Haitham AlRabiah, Mohammed Abounassif, Haya I. Aljohar and Gamal Abdel-Hafiz Mostafa

    Citation: BMC Chemistry 2019 13:121

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  2. Content type: Research article

    Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as a superior catalyst has been used for the synthesis of 3-alkyl-4-phenyl-1,3-thiazole-2(3H)-thione derivatives through a three-compo...

    Authors: Hossein Shahbazi-Alavi, Sheida Khojasteh-Khosro, Javad Safaei-Ghomi and Maryam Tavazo

    Citation: BMC Chemistry 2019 13:120

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  3. Content type: Research article

    The synthesized Fe3O4@l-arginine showed strong catalytic performance in the one-pot synthesis of spiropyranopyrazoles via the reactions of hydrazines, β-keto esters, isatins, and malononitrile or ethyl cyanoaceta...

    Authors: Mohammad Ali Ghasemzadeh, Boshra Mirhosseini-Eshkevari and Mohammad Hossein Abdollahi-Basir

    Citation: BMC Chemistry 2019 13:119

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  4. Content type: Research article

    In the present study two different RSLC columns, Acclaim RSLC 120 C18, 5.0 µm, 4.6 × 150 mm (column A) and Acclaim RSLC 120 C18, 2.2 µm, 2.1 × 100 mm (Column B) were utilized for the analysis of velpatasvir (V...

    Authors: Moustapha Eid Moustapha, Rania Mohamed El-Gamal and Fathalla Fathalla Belal

    Citation: BMC Chemistry 2019 13:118

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  5. Content type: Research article

    The transcription factor Nuclear factor erythroid-2-related factor 2 (NRF2) and its principal repressive regulator, Kelch-like ECH-associated protein 1 (KEAP1), are perilous in the regulation of inflammation, ...

    Authors: Murugesh Kandasamy, Kit-Kay Mak, Thangaraj Devadoss, Punniyakoti Veeraveedu Thanikachalam, Raghavendra Sakirolla, Hira Choudhury and Mallikarjuna Rao Pichika

    Citation: BMC Chemistry 2019 13:117

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  6. Content type: Research article

    Pyrazoles, thiazoles and fused thiazoles have been reported to possess many biological activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a,b (obtained from the reaction of ...

    Authors: Abdelwahed R. Sayed, Sobhi M. Gomha, Fathy M. Abdelrazek, Mohamed S. Farghaly, Shaimaa A. Hassan and Peter Metz

    Citation: BMC Chemistry 2019 13:116

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  7. Content type: Research article

    2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis of diverse range of heterocyclic analogues with promising therapeutic roles as antibacteria...

    Authors: Saima Ejaz, Humaira Nadeem, Rehan Zafar Paracha, Sadia Sarwar and Sadaf Ejaz

    Citation: BMC Chemistry 2019 13:115

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  8. Content type: Research article

    Natural Bombyx mori silk fibroin (SF) fibers were modified with 2-methacryloyloxyethyl isocyanate (MOI) first for the introduction of vinyl groups. Then, 1H,1H,2H,2H-perfluorodecanethiol was grafted onto the SF f...

    Authors: Xiaoning Zhang, Jianwei Liang, Zhenyu Chen, Carrie Donley, Yuling Liu and Guotao Cheng

    Citation: BMC Chemistry 2019 13:114

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  9. Content type: Research article

    In the present study, a series of 2-(4-(2-chloroacetyl)piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives was synthesized and its chemical structures were confirmed by physicoche...

    Authors: Shinky Mehta, Sanjiv Kumar, Rakesh Kumar Marwaha, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:113

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  10. Content type: Mini review

    Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the di...

    Authors: Li Xu, Yanli Wen, Santosh Pandit, Venkata R. S. S. Mokkapati, Ivan Mijakovic, Yan Li, Min Ding, Shuzhen Ren, Wen Li and Gang Liu

    Citation: BMC Chemistry 2019 13:112

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  11. Content type: Research article

    In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (T...

    Authors: Chunhong Dong, Shuanglin Liu, Xiaodong Cheng, Qiang Wang, Shiqing Jiang and Guoqing Wang

    Citation: BMC Chemistry 2019 13:109

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  12. Content type: Research article

    The leaves and bark of Syringa oblata Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing and jaundice-relieving effects. There are many studies about leaves of S. oblata becau...

    Authors: Lili Cui, Miyun Hu, Pengran Cao, Yun Niu, Changqin Li, Zhenhua Liu and Wenyi Kang

    Citation: BMC Chemistry 2019 13:108

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  13. Content type: Research article

    The main objective of this study is treatment and characterization of phosphorus from synthetic wastewater using aluminum electrodes in the electrocoagulation process. EC experimental setups were designed and ...

    Authors: Dessie Tibebe, Yezbie Kassa and Ashok N. Bhaskarwar

    Citation: BMC Chemistry 2019 13:107

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  14. Content type: Review

    Cannabis products (marijuana, weed, hashish) are among the most widely abused psychoactive drugs in the world, due to their euphorigenic and anxiolytic properties. Recently, hair analysis is of great interest ...

    Authors: Iltaf Shah, Bayan Al-Dabbagh, Alaa Eldin Salem, Saber A.A. Hamid, Neak Muhammad and Declan P. Naughton

    Citation: BMC Chemistry 2019 13:106

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  15. Content type: Research article

    Tartrazine (Yellow 5 or E102) is a synthetic food dye able to modify perception and behavior, causing agitation, confusion, rhinitis and can produce hyperactivity syndrome in children when is combined with ben...

    Authors: Igori Balta, Bogdan Sevastre, Vioara Mireşan, Marian Taulescu, Camelia Raducu, Adina Lia Longodor, Zamfir Marchiş, Codruta Stefania Mariş and Aurelia Coroian

    Citation: BMC Chemistry 2019 13:104

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  16. Content type: Research article

    We have synthesized new series of bisindole analogs (127), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 ...

    Authors: Muhammad Taha, Imad Uddin, Mohammed Gollapalli, Noor Barak Almandil, Fazal Rahim, Rai Khalid Farooq, Muhammad Nawaz, Mohamed Ibrahim, Mohammed A. Alqahtani, Yasser A. Bamarouf and Manikandan Selvaraj

    Citation: BMC Chemistry 2019 13:102

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  17. Content type: Research article

    Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compound...

    Authors: Btissam Bouchal, Farid Abrigach, Abdelilah Takfaoui, Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Pierre H. Dixneuf, Henri Doucet, Rachid Touzani and Mohammed Bellaoui

    Citation: BMC Chemistry 2019 13:100

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  18. Content type: Research article

    Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, to simplify prescribing and to improve patient comp...

    Authors: Christine M. El-Maraghy and Nesrine T. Lamie

    Citation: BMC Chemistry 2019 13:99

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  19. Content type: Research article

    Sevelamer (polyallyamine resin)-supported sulfonic acid (S-SO3H) has been prepared from the reaction of sevelamer with chlorosulfonic acid and characterized using FT-IR spectroscopy, scanning electronmicroscopy (...

    Authors: Xian-Liang Zhao, Makombe Shelton and Ke-Fang Yang

    Citation: BMC Chemistry 2019 13:98

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  20. Content type: Research article

    Cu2O supported on peanut shell (Cu2O@PS) was prepared by the reaction of copper acetate and peanut shell powder as a naturally available biopolymer support. The prepared catalyst was used as an efficient and reus...

    Authors: Zahra Dolatkhah, Abolfazl Mohammadkhani, Shahrzad Javanshir and Ayoob Bazgir

    Citation: BMC Chemistry 2019 13:97

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  21. Content type: Research article

    Heterocyclic 1,3-diazine nucleus is a valuable pharmacophore in the field of medicinal chemistry and exhibit a wide spectrum of biological activities. PharmMapper, a robust online tool used for establishing th...

    Authors: Sanjiv Kumar, Deepika Sharma, Balasubramanian Narasimhan, Kalavathy Ramasamy, Syed Adnan Ali Shah, Siong Meng Lim and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:96

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  22. Content type: Research article

    Sodium benzoate (SB) is widely used as a preservative in food industry, and bovine serum albumin (BSA) is a major carrier protein similar to human serum albumin (HSA), the study of the binding between the two ...

    Authors: Jing Yu, Jian-Yi Liu, Wei-Ming Xiong, Xiao-Yue Zhang and Yue Zheng

    Citation: BMC Chemistry 2019 13:95

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  23. Content type: Research article

    Flickingeria fimbriata is commonly applied in China as a traditional Chinese medicine (TCM), however the quality control of it is incomplete. In this work, we aim to identify and quantify the structures of C-glyc...

    Authors: Yawen Wang, Zhiyun Liang, Xian Liao, Chujuan Zhou, Zhenshan Xie, Sha Zhu, Gang Wei and Yuechun Huang

    Citation: BMC Chemistry 2019 13:94

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  24. Content type: Research article

    Bidi, an indigenous form of cigarette in South Asian countries, is popular because of its low cost and multi-flavored variants. Although recent studies have shown that bidi smokers suffer from various adverse ...

    Authors: Omobola Ajoke Oladipupo, Dibyendu Dutta and Ngee Sing Chong

    Citation: BMC Chemistry 2019 13:93

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  25. Content type: Research article

    Atractylodis rhizoma, is the dried rhizomes of Atractylodes lancea (Thunb.) DC. or A. chinensis (DC.) Koidz. Both of two are pharmacologically and economically important, while with differences in efficacy. There...

    Authors: Dan Zhuang, Jing Qin, Hui-yang Wang, Yi Zhang, Chun-yao Liu, Qing-qing Ding and Guang-ping Lv

    Citation: BMC Chemistry 2019 13:92

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  26. Content type: Research article

    Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibit...

    Authors: Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil and Saleh A. Ahmed

    Citation: BMC Chemistry 2019 13:91

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  27. Content type: Research article

    Benzimidazole is a valuable pharmacophore in the field of medicinal chemistry and exhibit wide spectrum of biological activity. Molecular docking technique is routinely used in modern drug discovery for unders...

    Authors: Sumit Tahlan, Sanjiv Kumar, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:90

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  28. Content type: Review

    Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form CN bond with high atom economy. The research progres...

    Authors: Jingpei Huo, Guozhang He, Weilan Chen, Xiaohong Hu, Qianjun Deng and Dongchu Chen

    Citation: BMC Chemistry 2019 13:89

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  29. Content type: Research article

    In continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (AE) by base catalyzed Claisen–Schmidt condensation with different...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:87

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  30. Content type: Research article

    Pesticides and herbicides have been used extensively in agricultural practices to control pests and increase crop yields. Paraquat (PQT2+, 1,1-dimethyl-4,4-dipyridinium chloride) is one of the herbicide that belo...

    Authors: Shehdeh Jodeh, Ghadir Hanbali, Said Tighadouini, Smaail Radi, Othman Hamed and Diana Jodeh

    Citation: BMC Chemistry 2019 13:86

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  31. Content type: Research article

    Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochem...

    Authors: Sanjiv Kumar, Archana Kaushik, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:85

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  32. Content type: Research article

    Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will affect greatly the drug discovery process.

    Authors: Heba Elmansi, Jenny Jeehan Nasr, Azza H. Rageh, Mohamed I. El-Awady, Ghada S. Hassan, Hatem A. Abdel-Aziz and Fathalla Belal

    Citation: BMC Chemistry 2019 13:84

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  33. Content type: Research article

    A simple, rapid and sensitive ultrahigh performance liquid chromatographic method was developed for the determination of the anti-diabetic drug: empagliflozin (EMPA) and three related substances in spiked huma...

    Authors: Mokhtar M. Mabrouk, Suzan M. Soliman, Heba M. El-Agizy and Fotouh R. Mansour

    Citation: BMC Chemistry 2019 13:83

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  34. Content type: Research article

    Highly sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous estimation of the recently approved oral hypoglycemic mixture; m...

    Authors: Dalia Mohamed, Mona S. Elshahed, Tamer Nasr, Nageh Aboutaleb and Ola Zakaria

    Citation: BMC Chemistry 2019 13:82

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  35. Content type: Research article

    The dynamic changes of secondary metabolites and tyrosinase activity of Malus pumila flowers were investigated during blooming for full use of M. pumila flowers. Phlorizin, astragalin and afzelin were selected as...

    Authors: Lili Cui, Xingzi Hou, Wenjing Li, Yuchun Leng, Yang Zhang, Xinjuan Li, Yangyang Hou, Zhenhua Liu and Wenyi Kang

    Citation: BMC Chemistry 2019 13:81

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  36. Content type: Research article

    The use of natural cellulosic fibers as materials in the reinforcements of polymer composites and sorption of oil from water, has directed more focus on acetylation than other known chemical modification metho...

    Authors: Jude Chinedu Onwuka, Edith Bolanle Agbaji, Victor Olatunji Ajibola and Friday Godwin Okibe

    Citation: BMC Chemistry 2019 13:79

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  37. Content type: Research article

    Comtrex® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This study has overcome the challenging dosage form ratio (250:15:1) an...

    Authors: Souha Hosam Youssef, Dalia Mohamed, Maha Abdel Monem Hegazy and Amr Badawey

    Citation: BMC Chemistry 2019 13:78

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  38. Content type: Research article

    The various extracts of Trifolium resupinatum (Persian clover) sprout was obtained by using different solvents and microwave assisted extraction in the present study. Then, the bifunctionalized nanoliposomes were...

    Authors: S. Zahra Sayyed-Alangi and Meysam Nematzadeh

    Citation: BMC Chemistry 2019 13:77

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  39. Content type: Methodology article

    5-Hydroxytryptamine (also known as 5-HT, serotonin) is one of the monoamine neurotransmitters which is distributed widely in plasma and brain of mammals and plays important roles in physiological manipulations...

    Authors: Qiangqiang He, Maoru Li, Xuechun Wang, Zhenjiang Xia, Yuzhi Du, Yan Li, Lixin Wei and Jing Shang

    Citation: BMC Chemistry 2019 13:76

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  40. Content type: Research article

    One of the major causes of mortality all over the world is chronic obstructive pulmonary disease (COPD). Recently approved combined inhaler of formoterol fumarate (FF) and glycopyrronium bromide (GLY) has been...

    Authors: Yomna A. Salem, Mohammed E. A. Hammouda, Mohamed A. Abu El-Enin and Saadia M. El-Ashry

    Citation: BMC Chemistry 2019 13:75

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  41. Content type: Research article

    Gracilaria lemaneiformis is a common red alga used as a raw material source for the agar industry. Its extract is rich in natural volatile constituents (VCs) having antioxidant activities. Herein, a sustainable m...

    Authors: Shengliang Yuan, Kefeng Wu, Zhihong Duan, Yanxia Huang, Yingnian Lu and Xiaoli Ma

    Citation: BMC Chemistry 2019 13:74

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