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  1. Content type: Research article

    Atractylodis rhizoma, is the dried rhizomes of Atractylodes lancea (Thunb.) DC. or A. chinensis (DC.) Koidz. Both of two are pharmacologically and economically important, while with differences in efficacy. There...

    Authors: Dan Zhuang, Jing Qin, Hui-yang Wang, Yi Zhang, Chun-yao Liu, Qing-qing Ding and Guang-ping Lv

    Citation: BMC Chemistry 2019 13:92

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  2. Content type: Research article

    Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibit...

    Authors: Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil and Saleh A. Ahmed

    Citation: BMC Chemistry 2019 13:91

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  3. Content type: Research article

    Benzimidazole is a valuable pharmacophore in the field of medicinal chemistry and exhibit wide spectrum of biological activity. Molecular docking technique is routinely used in modern drug discovery for unders...

    Authors: Sumit Tahlan, Sanjiv Kumar, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:90

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  4. Content type: Review

    Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form CN bond with high atom economy. The research progres...

    Authors: Jingpei Huo, Guozhang He, Weilan Chen, Xiaohong Hu, Qianjun Deng and Dongchu Chen

    Citation: BMC Chemistry 2019 13:89

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  5. Content type: Research article

    In continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (AE) by base catalyzed Claisen–Schmidt condensation with different...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:87

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  6. Content type: Research article

    Pesticides and herbicides have been used extensively in agricultural practices to control pests and increase crop yields. Paraquat (PQT2+, 1,1-dimethyl-4,4-dipyridinium chloride) is one of the herbicide that belo...

    Authors: Shehdeh Jodeh, Ghadir Hanbali, Said Tighadouini, Smaail Radi, Othman Hamed and Diana Jodeh

    Citation: BMC Chemistry 2019 13:86

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  7. Content type: Research article

    Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochem...

    Authors: Sanjiv Kumar, Archana Kaushik, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:85

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  8. Content type: Research article

    Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will affect greatly the drug discovery process.

    Authors: Heba Elmansi, Jenny Jeehan Nasr, Azza H. Rageh, Mohamed I. El-Awady, Ghada S. Hassan, Hatem A. Abdel-Aziz and Fathalla Belal

    Citation: BMC Chemistry 2019 13:84

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  9. Content type: Research article

    A simple, rapid and sensitive ultrahigh performance liquid chromatographic method was developed for the determination of the anti-diabetic drug: empagliflozin (EMPA) and three related substances in spiked huma...

    Authors: Mokhtar M. Mabrouk, Suzan M. Soliman, Heba M. El-Agizy and Fotouh R. Mansour

    Citation: BMC Chemistry 2019 13:83

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  10. Content type: Research article

    Highly sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous estimation of the recently approved oral hypoglycemic mixture; m...

    Authors: Dalia Mohamed, Mona S. Elshahed, Tamer Nasr, Nageh Aboutaleb and Ola Zakaria

    Citation: BMC Chemistry 2019 13:82

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  11. Content type: Research article

    The dynamic changes of secondary metabolites and tyrosinase activity of Malus pumila flowers were investigated during blooming for full use of M. pumila flowers. Phlorizin, astragalin and afzelin were selected as...

    Authors: Lili Cui, Xingzi Hou, Wenjing Li, Yuchun Leng, Yang Zhang, Xinjuan Li, Yangyang Hou, Zhenhua Liu and Wenyi Kang

    Citation: BMC Chemistry 2019 13:81

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  12. Content type: Research article

    The use of natural cellulosic fibers as materials in the reinforcements of polymer composites and sorption of oil from water, has directed more focus on acetylation than other known chemical modification metho...

    Authors: Jude Chinedu Onwuka, Edith Bolanle Agbaji, Victor Olatunji Ajibola and Friday Godwin Okibe

    Citation: BMC Chemistry 2019 13:79

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  13. Content type: Research article

    Comtrex® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This study has overcome the challenging dosage form ratio (250:15:1) an...

    Authors: Souha Hosam Youssef, Dalia Mohamed, Maha Abdel Monem Hegazy and Amr Badawey

    Citation: BMC Chemistry 2019 13:78

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  14. Content type: Research article

    The various extracts of Trifolium resupinatum (Persian clover) sprout was obtained by using different solvents and microwave assisted extraction in the present study. Then, the bifunctionalized nanoliposomes were...

    Authors: S. Zahra Sayyed-Alangi and Meysam Nematzadeh

    Citation: BMC Chemistry 2019 13:77

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  15. Content type: Methodology article

    5-Hydroxytryptamine (also known as 5-HT, serotonin) is one of the monoamine neurotransmitters which is distributed widely in plasma and brain of mammals and plays important roles in physiological manipulations...

    Authors: Qiangqiang He, Maoru Li, Xuechun Wang, Zhenjiang Xia, Yuzhi Du, Yan Li, Lixin Wei and Jing Shang

    Citation: BMC Chemistry 2019 13:76

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  16. Content type: Research article

    One of the major causes of mortality all over the world is chronic obstructive pulmonary disease (COPD). Recently approved combined inhaler of formoterol fumarate (FF) and glycopyrronium bromide (GLY) has been...

    Authors: Yomna A. Salem, Mohammed E. A. Hammouda, Mohamed A. Abu El-Enin and Saadia M. El-Ashry

    Citation: BMC Chemistry 2019 13:75

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  17. Content type: Research article

    Gracilaria lemaneiformis is a common red alga used as a raw material source for the agar industry. Its extract is rich in natural volatile constituents (VCs) having antioxidant activities. Herein, a sustainable m...

    Authors: Shengliang Yuan, Kefeng Wu, Zhihong Duan, Yanxia Huang, Yingnian Lu and Xiaoli Ma

    Citation: BMC Chemistry 2019 13:74

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  18. Content type: Research article

    Paeonia suffruticosa is an important traditional Chinese herb used to treat osteoarthritis (OA) and oligostilbenes are the main active ingredient of the seeds of P. suffruticosa. The monomer trans-resveratrol of ...

    Authors: Yu-Kun He, Xiao-tong Cen, Shuang-shuang Liu, Hua-ding Lu and Chun-nian He

    Citation: BMC Chemistry 2019 13:72

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  19. Content type: Research article

    Parabens and sorbic acid are commonly used as food preservatives due to their antimicrobial effect. However, their use in foods for infants and young children is not permitted in the European Union. Previous s...

    Authors: Theodoros Potouridis, Alena Knauz, Elisabeth Berger and Wilhelm Püttmann

    Citation: BMC Chemistry 2019 13:70

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  20. Content type: Research article

    The title compounds, 2-azaspiro[4.5]deca-1-one, C9H15NO, (1a), cis-8-methyl-2-azaspiro[4.5]deca-1-one, C10H17NO, (1b), and trans-8-methyl-2-azaspiro[4.5]deca-1-one, C10H17NO, (1c), were synthesized from benzoic a...

    Authors: Tobias Krueger, Alexandra Kelling, Torsten Linker and Uwe Schilde

    Citation: BMC Chemistry 2019 13:69

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  21. Content type: Research article

    Ru(bpy)2dppz2+ has been widely used as a probe for exploring the structure of double-stranded DNA (dsDNA). The flexibility change of DNA helix is important in many of its biological functions but not well underst...

    Authors: Fuchao Jia, Pascal Hébraud, Kezhen Han, Jing Wang, Xingguo Liang and Bo Liu

    Citation: BMC Chemistry 2019 13:68

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  22. Content type: Research article

    The Zika virus (ZIKV) has gained attention for the last few years due to the congenital microcephaly and Guillain–Barre Syndrome that resulted in humans. The non-structural protein-3 (NS3) helicase of ZIKV pla...

    Authors: Syed Lal Badshah, Nasir Ahmad, Ashfaq Ur Rehman, Khalid Khan, Asad Ullah, Abdulrhman Alsayari, Abdullatif Bin Muhsinah and Yahia N. Mabkhot

    Citation: BMC Chemistry 2019 13:67

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  23. Content type: Research article

    In search of effective antimicrobial and cytotoxic agents, a series of indole hybridized diazenyl derivatives (DS-1 to DS-21) was efficiently prepared by condensation of diazotized p-aminoacetophenone with indole...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:65

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  24. Content type: Research article

    Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics. One o...

    Authors: Juraj Piestansky, Jaroslav Galba, Dominika Olesova, Branislav Kovacech and Andrej Kovac

    Citation: BMC Chemistry 2019 13:64

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  25. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Schemes 1 and 2 and repeated line in subsection “Bis(ligand) nickel(II) chelate (NiL12)”.

    Authors: Mei Luo, Jing Cheng Zhang, Hao Yin, Cheng Ming Wang, Susan Morris-Natschke and Kuo-Hsiung Lee

    Citation: BMC Chemistry 2019 13:63

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    The original article was published in BMC Chemistry 2019 13:51

  26. Content type: Research article

    Bombyx mori silk fibroin-based materials have good biocompatibility and biodegradability. In order to maximize their utility while maintain appropriate features, silk fibroin (SF) films were modified with reduced...

    Authors: Xiaoning Zhang, Hong Bao, Carrie Donley, Jianwei Liang, Sha Yang and Shui Xu

    Citation: BMC Chemistry 2019 13:62

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  27. Content type: Research article

    In this study, a simple one-step ionic liquid-based ultrasound-assisted dispersive liquid–liquid microextraction technique was coupled with high-performance liquid chromatography for the analysis of four pyret...

    Authors: Yiyi Liao, Yuge Hou, Yan Zhong, Hong Chen, Chang Xu, Makoto Tsunoda, Yingxia Zhang, Shiming Deng and Yanting Song

    Citation: BMC Chemistry 2019 13:61

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  28. Content type: Research article

    In order to overcome the challenges of microbial resistance as well as to improve the effectiveness and selectivity of chemotherapeutic agents against cancer, a novel series of 4-(4-bromophenyl)-thiazol-2-amin...

    Authors: Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:60

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  29. Content type: Research article

    This paper describes the application of response surface methodology (RSM) to develop a miniaturized metal organic framework based pipette-tip solid phase extraction for the extraction of malachite green (MG),...

    Authors: Sayyed Hossein Hashemi, Massoud Kaykhaii, Ahmad Jamali Keikha, Elahe Mirmoradzehi and Ghasem Sargazi

    Citation: BMC Chemistry 2019 13:59

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  30. Content type: Research article

    Escalating energy security, burgeoning population and rising costs of fossil fuels have focussed our attention on tapping renewable energy sources. As the utilization of food crops for biofuel production culmi...

    Authors: Rintu Banerjee, Anjani Devi Chintagunta and Subhabrata Ray

    Citation: BMC Chemistry 2019 13:58

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  31. Content type: Research article

    Thanks to its specific chemical and physical properties, graphene has aroused growing interest in many fields of Science and Technology. The present study focuses on the properties of microcrystalline chitosan...

    Authors: Marta E. Lichawska, Aleksander Kufelnicki and Magdalena Woźniczka

    Citation: BMC Chemistry 2019 13:57

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  32. Content type: Research article

    Identification and screening of cultivars rich in bioactive phytoconstituents can be potentially useful to make nutrient-dense dishes and in medicinal formulations. In this study, we have identified, character...

    Authors: Awraris Derbie Assefa, Susanna Choi, Jae-Eun Lee, Jung-Sook Sung, On-Sook Hur, Na-Young Ro, Ho-Sun Lee, Suk-Woo Jang and Ju-Hee Rhee

    Citation: BMC Chemistry 2019 13:56

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  33. Content type: Research article

    Many reports have also shown that the silver nanoparticles can effectively increase the anticancer drug activity and intensely enhance the drug curative effect. The adsorption of 6MP on nanomaterials has recei...

    Authors: Hongjiang Ren, Fan Chen, Xiaojun Li and Yaping He

    Citation: BMC Chemistry 2019 13:55

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  34. Content type: Research article

    Diabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorp...

    Authors: Hatem A. Abuelizz, Nor Azman N. I. Iwana, Rohaya Ahmad, El-Hassane Anouar, Mohamed Marzouk and Rashad Al-Salahi

    Citation: BMC Chemistry 2019 13:52

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  35. Content type: Research article

    The general approach to the synthesis of metal complexes begins with ligand synthesis, followed by ligand reaction with metal salts to afford organometallic complexes. Our research group first reported a one-p...

    Authors: Mei Luo, Jing Cheng Zhang, Hao Yin, Cheng Ming Wang, Susan Morris-Natschke and Kuo-Hsiung Lee

    Citation: BMC Chemistry 2019 13:51

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    The Correction to this article has been published in BMC Chemistry 2019 13:63

  36. Content type: Research article

    Nitrogen containing heterocycles are widely used and investigated by pharmaceutical industry, as they are important in discovery and designing of new drug molecules. Drugs with a benzimidazole nucleus possess ...

    Authors: Sumit Tahlan, Sanjiv Kumar, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani, Ranjana Pathania and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:50

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  37. Content type: Research article

    In search of new antimicrobial and cytotoxic agents, a series of new naphthol diazenyl scaffold based Schiff bases (NS1NS23) was efficiently synthesized by condensation of 2-hydroxy naphthaldehyde azo dyes with ...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:49

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  38. Content type: Research article

    Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores w...

    Authors: Abdou O. Abdelhamid, Ibrahim E. El Sayed, Yasser H. Zaki, Ahmed M. Hussein, Mangoud M. Mangoud and Mona A. Hosny

    Citation: BMC Chemistry 2019 13:48

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  39. Content type: Research article

    The medicinal plant Tirpitzia sinensis has been used by the Zhuang ethnic people in mountainous areas of Southwest China to stop bleeding, invigorate blood circulation, and treat inflammation and wounds. In order...

    Authors: Ronghui Gu, Yuehu Wang, Shibiao Wu, Yeling Wang, Ping Li, Li Xu, Yue Zhou, Ze’e Chen, Edward J. Kennelly and Chunlin Long

    Citation: BMC Chemistry 2019 13:47

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  40. Content type: Research article

    To combat the antimicrobial and anticancer drug resistance by pathogens and cancerous cells, efforts has been made to study the pharmacological activities of newly synthesized N-(4-(4-bromophenyl)thiazol-2-yl)-2-...

    Authors: Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:46

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  41. Content type: Research article

    Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches...

    Authors: Ritu Kataria and Anurag Khatkar

    Citation: BMC Chemistry 2019 13:45

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  42. Content type: Research article

    The existence of heavy metals and coliform bacteria contaminants in aquatic system of Akaki river basin, a sub city of Addis Ababa, Ethiopia has become a public concern as human population increases and land d...

    Authors: Feleke Terefe Fanta, Amare Aregahegn Dubale, Dawit Firemichael Bebizuh and Minaleshewa Atlabachew

    Citation: BMC Chemistry 2019 13:44

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  43. Content type: Research article

    A convenient approach for (1E,3E)-1,4-diarylbuta-1,3-dienes via intermolecular Heck reaction of olefins and β-bromostyrenes promoted by μ-OMs palladium–dimer complex has been successfully developed. The products ...

    Authors: Xueliang Zhou, Yuan Zhou, Qiang Zhu, Huimin Chen, Nan Wu, Xiangru Wen and Zhou Xu

    Citation: BMC Chemistry 2019 13:39

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