Articles

Heating effect on quality characteristics of mixed canola cooking oils

The subcontinent is famous for its variety of seasonal foods cooked in vegetable seed cooking oils at elevated heating. Oils are often of poor quality that effect to consumer health. The work, therefore, plann...

Authors: Ayesha Baig, Muhammad Zubair, Sajjad Hussain Sumrra, Muhammad Faizan Nazar, Muhammad Nadeem Zafar, Kausar Jabeen, Muhammad Bilal Hassan and Umer Rashid

Kinetic control concept for the diffusion processes of paracetamol active molecules across affinity polymer membranes from acidic solutions

Paracetamol compound remains the most used pharmaceutical as an analgesic and antipyretic for pain and fever, often identified in aquatic environments. The elimination of this compound from wastewater is one o...

Authors: Sanae Tarhouchi, Rkia Louafy, El Houssine El Atmani and Miloudi Hlaïbi

Synthesis, in silico molecular docking analysis, pharmacokinetic properties and evaluation of antibacterial and antioxidant activities of fluoroquinolines

Quinolines have demonstrated various biological activities such as antimalarial, antibacterial and anticancer. Hence, compounds with such scaffold have been used as lead in drug development. This project is, t...

Authors: Mona Fekadu, Digafie Zeleke, Bayan Abdi, Anuradha Guttula, Rajalakshmanan Eswaramoorthy and Yadessa Melaku

Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study

Thiazole-based Schiff base compounds display significant pharmacological potential with an ability to modulate the activity of many enzymes involved in metabolism. They also demonstrated to have antibacterial,...

Authors: Fitsum Lemilemu, Mamaru Bitew, Taye B. Demissie, Rajalakshmanan Eswaramoorthy and Milkyas Endale

Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines

Liver cancer is predicted to be the sixth most diagnosed cancer globally and fourth leading cause of cancer deaths. In this study, a series of indole-3-isoxazole-5-carboxamide derivatives were designed, synthe...

Authors: Mohammed Hawash, Deniz Cansen Kahraman, Sezen Guntekin Ergun, Rengul Cetin-Atalay and Sultan Nacak Baytas

Solvothermal synthesis of pure and Sn-doped Bi₂S₃ and the evaluation of their photocatalytic activity on the degradation of methylene blue

A large volume of dye molecules finds its way into the environment, accumulates in water bodies, and makes the aquatic system unsafe to human health. Due to the complex nature of these dye materials, most of t...

Authors: Violet M. Nkwe, Damian C. Onwudiwe and Mayowa A. Azeez

Inonotus obliquus polysaccharide ameliorates serum profiling in STZ-induced diabetic mice model

Diabetes mellitus is a systemic disease mainly caused by the disorder of metabolism, which has become huge threat to human health. Polysaccharides are the main active substance from Inonotus obliquus (I. obliquus...

Authors: Tanye Xu, Guodao Li, Xiaobo Wang, Chongning Lv and Yuanyong Tian

Correction to: Chromium‑based metal organic framework for pipette tip micro‑solid phase extraction: an effective approach for determination of methyl and propyl parabens in wastewater and shampoo samples

Authors: Massoud Kaykhaii, Sayyed Hossein Hashemi, Fariba Andarz, Amin Piri and Ghasem Sargazi

A new LC–MS/MS method for multiple residues/contaminants in bovine meat

A multi-class and multi-residue/contaminant method for the determination of veterinary drug and pesticide residues and mycotoxins in bovine meat has been developed and validated. The veterinary drug residues/c...

Authors: Zehra Hajrulai-Musliu, Risto Uzunov, Stefan Jovanov, Dean Jankuloski, Velimir Stojkovski, Lazo Pendovski and James Jacob Sasanya

n-Heptane isomerization activities of Pt catalyst supported on micro/mesoporous composites

Pt loaded on a series of MCM-48 silica and composites with HZSM-5 zeolite, HY zeolite, or TiO₂ has been prepared and studied for n-heptane isomerization reaction at 200–350 °C. The structural characterization, ac...

Authors: Z. Ghaderi, M. H. Peyrovi and N. Parsafard

Chromium-based metal organic framework for pipette tip micro-solid phase extraction: an effective approach for determination of methyl and propyl parabens in wastewater and shampoo samples

A chromium-based metal organic framework was synthesized and employed as an efficient sorbent for pipette tip micro-solid phase extraction and preconcentration of parabens from wastewater and shampoo samples u...

Authors: Massoud Kaykhaii, Sayyed Hossein Hashemi, Fariba Andarz, Amin Piri and Ghasem Sargazi

Synthesis of bimannich base with thiazole and its corrosion inhibition effect on H₂S and CO₂ at high temperature

A bimannich-based TZBM containing a thiazole ring was obtained by synthesis of mannich bases. TZBM featured a stable structure at 260 °C, and corrosion inhibition effect on carbon steel in a gas–liquid environ...

Authors: Li Zhuoke, Cao Jun, Mao Ting and Ni Dan

Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues

Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues were designed and synthesised as novel antimicrobial drugs through inhibition of phenylalanyl-tRNA synthetase (PheRS), which is ...

Authors: Nada A. Noureldin, Jennifer Richards, Hend Kothayer, Mohammed M. Baraka, Sobhy M. Eladl, Mandy Wootton and Claire Simons

The effect of microwave stabilization on the properties of whole wheat flour and its further interpretation by molecular docking

In order to stabilize the whole wheat flour and extend its shelf life, microwave was employed to heat the wheat bran to inactivate the lipase in this paper. The effects of microwave heating of wheat bran on th...

Authors: Chenling Qu, Qiankui Yang, Lina Ding, Xueke Wang, Shengqiang Liu and Min Wei

Preparation of a new coating of graphene oxide/nickel complex on a nickelized metal surface for direct immersion solid phase microextraction of some polycyclic aromatic hydrocarbons

Solid-phase microextraction (SPME) is a versatile sampling and sample preparation technology that possess a significant application in the extraction and pre-concentration of a broad range of micro-pollutants ...

Authors: Yalda Pasandideh and Habib Razmi

Phytochemical analysis, antioxidant and in vitro β-galactosidase inhibition activities of Juniperus phoenicea and Calicotome villosa methanolic extracts

Juniperus Phoenicea (JP) and Calicotome Villosa (CV) are used by Jordanian populations as herbal remedies in traditional medicine. Herein, the phytochemical contents of their methanolic extracts were analyzed and...

Authors: Ahmed Al-Mustafa, Mohammad Al-Tawarah, Mohammed Sharif Al-Sheraideh and Fatema Attia Al-Zahrany

Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors

A series of symmetrical azine derivatives containing different substituted benzyl moieties were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase. The results showed that co...

Authors: Somaye Karimian, Fatemeh Kazemi, Mahshid Attarroshan, Maryam Gholampour, Shiva Hemmati, Amirhossein Sakhteman, Yasaman Behzadipour, Maryam Kabiri, Aida Iraji and Mehdi Khoshneviszadeh

Solvent effect on the absorption and emission spectra of carbon dots: evaluation of ground and excited state dipole moment

Carbon dots (C-dots) are photoluminescent nanoparticles with less than 10 nm in size. Today, many studies are performed to exploit the photoluminescence (PL) property of carbon dots, and our focus in this stud...

Authors: Parisa Mohammad-Jafarieh, Abolfazl Akbarzadeh, Rahman Salamat-Ahangari, Mohammad Pourhassan-Moghaddam and Kazem Jamshidi-Ghaleh

Inter-laboratory comparison of water solubility methods applied to difficult-to-test substances

Water solubility is perhaps the single most important physical–chemical property determining the environmental fate and effects of organic compounds. Its determination is particularly challenging for compounds...

Authors: Daniel J. Letinski, Aaron D. Redman, Heidi Birch and Philipp Mayer

Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence

Local sequence context is known to have an impact on the mutational pattern seen in cancer. The RAS genes and a smoking carcinogen, Benzo[a]pyrene diol epoxide (BPDE), have been utilised to explore these context ...

Authors: Georgina E. Menzies, Ian A. Prior, Andrea Brancale, Simon H. Reed and Paul D. Lewis

Characterization and purification of Algerian natural bentonite for pharmaceutical and cosmetic applications

Bentonitic clays from the Hammam Boughrara deposit in the Maghnia area (northwestern Algeria) were studied by mineralogical, chemical and physicochemical characterization to evaluate their potential suitabilit...

Authors: Nabil Babahoum and Malek Ould Hamou

Composition analysis and microencapsulation of Eucommia ulmoides seed oil

Eucommia ulmoides seed oil is a functional health oil with a high content of unsaturated fatty acids. However, excessively high content of unsaturated fatty acids can cause E. ulmoides seed oil to easily spoil. M...

Authors: Zhang Huirong, Zhang huina, Chen Nifeng and Li Li

Statistical optimization of amorphous iron phosphate: inorganic sol–gel synthesis-sodium potential insertion

Iron phosphate, Fe₂ (HPO₄)₃*4H₂O, is synthesized at ambient temperature, using the inorganic sol–gel method coupled to the microwave route. The experimental conditions for the gelling of Fe (III)-H₃PO₄ system are...

Authors: Fz. Maarouf, S. Saoiabi, K. Azzaoui, C. Chrika, H. Khalil, S. Elkaouni, S. Lhimr, O. Boubker, B. Hammouti and S. Jodeh

Effect of pH and concentration on the chemical stability and reaction kinetics of thiamine mononitrate and thiamine chloride hydrochloride in solution

Thiamine (vitamin B₁) is an essential micronutrient in the human diet, found both naturally and as a fortification ingredient in many foods and supplements. However, it is susceptible to degradation due to heat, ...

Authors: Adrienne L. Voelker, Lynne S. Taylor and Lisa J. Mauer

Chemical composition, energy and nutritional values, digestibility and functional properties of defatted flour, protein concentrates and isolates from Carbula marginella (Hemiptera: Pentatomidae) and Cirina butyrospermi (Lepidoptera: Saturniidae)

Edible insects constitute a potential source of alternative proteins as a food supplement. The present study aimed to investigate the chemical composition, energy and nutritional values, the digestibility and ...

Authors: Aminata Séré, Adjima Bougma, Bazoin Sylvain Raoul Bazié, Esther Traoré, Charles Parkouda, Olivier Gnankiné and Imael Henri Nestor Bassolé

Aesculin based glucosamine-6-phosphate synthase inhibitors as novel preservatives for food and pharmaceutical products: in-silico studies, antioxidant, antimicrobial and preservative efficacy evaluation

Presently available chemical based synthetic preservative have emerged with various side effects, so the aspiration of natural and side effect free novel preservative has been greatly increased. As the natural...

Authors: Amit Lather, Sunil Sharma and Anurag Khatkar

Active constituents of Zanthoxylum nitidium from Yunnan Province against leukaemia cells in vitro

Zanthoxylum nitidium (Roxb.) DC (Rutaceae) is well known for inhibiting the proliferation of human gastric, liver, kidney and lung cancer cells, though research on its potential use in treating leukaemia is relat...

Authors: Ying Deng, Tongtong Ding, Lulu Deng, Xiaojiang Hao and Shuzhen Mu

Evaluation of compost quality from municipal solid waste integrated with organic additive in Mizan–Aman town, Southwest Ethiopia

The present study evaluated the compost quality from municipal solid waste (MSW) and organic additives of coffee by-products and leaf of Millettia ferruginea. Compost sample (n = 30) was taken from fresh compost ...

Authors: Masresha Mamo, Henok Kassa, Lalit Ingale and Stefaan Dondeyne

A novel approach for the synthesis of nanostructured Ag₃PO₄ from phosphate rock: high catalytic and antibacterial activities

Silver orthophosphate (Ag₃PO₄) has received enormous attention over the past few years for its higher visible light photocatalytic performance as well as for various organic pollutants degradation in aqueous medi...

Authors: Karim Dânoun, Rida Tabit, Abdelaziz Laghzizil and Mohamed Zahouily

Ephedra alata fruit extracts: phytochemical screening, anti-proliferative activity and inhibition of DPPH, α-amylase, α-glucosidase, and lipase enzymes

Discovering and screening for potential anti-obesity, anti-diabetic, anticancer, and antioxidant treatments from natural products still in recent times the main goal for many pharmaceutical scientists. The pre...

Authors: Nidal Jaradat, Hanaa Dacca, Mohammed Hawash and Murad N. Abualhasan

Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives

Currently, available therapies for diabetes could not achieve normal sugar values in a high percentage of treated patients. In this research project, a series of 17 benzodioxole derivatives were evaluated as a...

Authors: Mohammed Hawash, Nidal Jaradat, Suhaib Shekfeh, Murad Abualhasan, Ahmad M. Eid and Linda Issa

Simultaneous determination of five diuretic drugs using quantitative analysis of multiple components by a single marker

Loop diuretics are commonly used in clinical practice to manage high fluid loads and to control fluid balance. In this paper, a novel quantitative analysis method for multiple components with a single marker (...

Authors: Fuchao Chen, Baoxia Fang, Peng Li and Sicen Wang

Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities

Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several dr...

Authors: José Eduardo Cadena-Cruz, Luis M. Guamán-Ortiz, Juan Carlos Romero-Benavides, Natalia Bailon-Moscoso, Kevin E. Murillo-Sotomayor, Nadia V. Ortiz-Guamán and Jorge Heredia-Moya

High pressure systems as sustainable extraction and pre-treatment technologies for a holistic corn stover biorefinery

This mini-review assesses supercritical carbon dioxide (scCO₂) extraction and high-pressure carbon dioxide pre-treatment technologies for valorisation of corn stover agricultural residues with particular focus on...

Authors: Pakin Noppawan, Adrienne Gallant Lanctôt, Maria Magro, Pablo Gil Navarro, Nontipa Supanchaiyamat, Thomas M. Attard and Andrew J. Hunt

Hyaluronic acid–lipid binding

Phospholipid (PL)–hyaluronic acid (HA) interactions are relevant to aging-associated vitreous humor liquefaction, therapies for dry eye disease, skin-care products and synovial joint lubrication. Phosphatidyl ...

Authors: Anthony Ewurum, Abhishek Ashok Alur, Margaret Glenn, Abigail Schnepf and Douglas Borchman

Study on the reaction strategy of directional alkylation fulfilled by controlling the adsorption pose of benzene and methanol in space with Ru/HZSM-5

The alkylation of benzene with methanol is an important synthetic method that is widely used in various chemical production processes. However, obtaining a high selectivity for xylene and annihilating the MTO ...

Authors: Dongliang Wang, Yanwei Li, Yu Zhao, Dong Ji, Peng Dong and Guixian Li

Nano-SiO₂/DBN: an efficacious and reusable catalyst for one-pot synthesis of tetrahydrobenzo[b]pyran derivatives

The nano-sized particles enhance the exposed surface area of the active part of the catalyst, thereby increasing the contact between precursors and catalyst considerably. In this study, nano-SiO₂/1,5-diazabicyclo...

Authors: Maryam Mehravar, Bi Bi Fatemeh Mirjalili, Elaheh Babaei and Abdolhamid Bamoniri

Chemical compositions, antimicrobial effects, and cytotoxicity of Asia minor wormwood (Artemisia splendens Willd.) growing in Iran

Artemisia splendens from the Asteraceae family is a new source of biologically active compounds. The current study investigated to evaluate antimicrobial and cytotoxicity activity of methanolic extracts and th...

Authors: Fariba Heshmati Afshar, Masumeh Zadehkamand, Zahra Rezaei, Abbas Delazar, Vahideh Tarhriz and Parina Asgharian

Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5

Cucumis prophetarum is traditionally used to treat liver and lung disorders, heart failure, diarrhea, gonorrhea, skin infections, intestinal problems and cancer. In the present work, the isolation of two novel co...

Authors: Wario Galma, Milkyas Endale, Emebet Getaneh, Rajalakshmanan Eswaramoorthy, Temesgen Assefa and Yadessa Melaku

Drying methodology effect on the phenolic content, antioxidant activity of Myrtus communis L. leaves ethanol extracts and soybean oil oxidative stability

In this study, different drying methodologies (convective air, oven and microwave) of Myrtus communis L. (M. communis L.) leaves were conducted to investigate their effects on the levels of phenolic compounds, an...

Authors: Ahmed Snoussi, Ismahen Essaidi, Hayet Ben Haj Koubaier, Houda Zrelli, Ibrahim Alsafari, Tesic Živoslav, Jelena Mihailovic, Muhummadh Khan, Abdelfatteh El Omri, Tanja Ćirković Veličković and Nabiha Bouzouita

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents

1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory, analgesic, diabetic, immunosuppressive, α,β₃-...

Authors: Ravi Kumar Bommera, Shashikala Kethireddy, Rajeshwar Reddy Govindapur and Laxminarayana Eppakayala

Validated green spectrophotometric kinetic method for determination of Clindamycin Hydrochloride in capsules

Simple, sensitive, free of organic solvents, kinetic spectrophotometric method has been developed for the determination of Clindamycin Hydrochloride, both in pure form and Capsules. Method is based on reaction...

Authors: Shaza Affas and Amir Alhaj Sakur

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies

In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbi...

Authors: Mohsinul Mulk Bacha, Humaira Nadeem, Sumera Zaib, Sadia Sarwar, Aqeel Imran, Shafiq Ur Rahman, Hafiz Saqib Ali, Muazzam Arif and Jamshed Iqbal

Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

Environment-friendly fast and accurate mid-infrared spectroscopic methods have been developed for the quantitative analysis of doxorubicin hydrochloride (DOX) and arterolane maleate (ALM) in bulk and marketed ...

Authors: Ranju Bansal, Ranjit Singh and Khushpal Kaur

Optimization of SPME–GC–MS and characterization of floral scents from Aquilegia japonica and A. amurensis flowers

The floral scents of plants play a key role in plant reproduction through the communication between plants and pollinators. Aquilegia as a model species for studying evolution, however, there have been few studie...

Authors: Hua-Ying Wang, Wei Zhang, Jian-Hua Dong, Hao Wu, Yuan-Hong Wang and Hong-Xing Xiao

Synthesis, spectroscopic, electrochemical and photophysical properties of high band gap polymers for potential applications in semi-transparent solar cells

The design of new polymers able to filter the electromagnetic spectrum and absorb distinctly in the UV and high-energy part of visible spectrum is crucial for the development of semi-transparent solar cells. H...

Authors: Peshawa O. Amin, Kamal Aziz Ketuly, Salah Raza Saeed, Fahmi F. Muhammadsharif, Mark D. Symes, Avishek Paul and Khaulah Sulaiman

Phycocyanin content and nutritional profile of Arthrospira platensis from Mexico: efficient extraction process and stability evaluation of phycocyanin

Phycocyanin is a blue natural food colorant with multiple health benefits. Here we propose an efficient phycocyanin extraction method from Arthrospira platensis from Mexico. Three extraction methods were applied ...

Authors: Sanghamitra Khandual, Edgar Omar Lopez Sanchez, Hugo Espinosa Andrews and Jose Daniel Padilla de la Rosa

Oxidation of 1-propanol to propionic acid with hydrogen peroxide catalysed by heteropolyoxometalates

Propionic acid as a very valuable chemical is in high demand, and it is industrially produced via the oxo-synthesis of ethylene or ethyl alcohol and via the oxidation of propionaldehyde with oxygen. It is urge...

Authors: Minxue Liu, Fengli Yu, Bing Yuan, Congxia Xie and Shitao Yu

The development of an effective synthetic route of rilpivirine

Rilpivirine (RPV) was approved by the U.S. FDA (Food and Drug Administration) in 2011 to treat individuals infected with human immunodeficiency virus 1 (HIV-1). Significantly, rilpivirine is three fold more po...

Authors: Tao Zhang, Jiapei Yang, Zhongxia Zhou, Zhipeng Fu, Srinivasulu Cherukupalli, Dongwei Kang, Peng Zhan and Xinyong Liu

Efficient and selective catalytic hydroxylation of unsaturated plant oils: a novel method for producing anti-pathogens

With the increasing demand for antimicrobial agents and the spread of antibiotic resistance in pathogens, the exploitation of plant oils to partly replace antibiotic emerges as an important source of fine chem...

Authors: Ahmed M. Senan, Binru Yin, Yaoyao Zhang, Mustapha M. Nasiru, Yong‐Mei Lyu, Muhammad Umair, Javaid A. Bhat, Sicheng Zhang and Li Liu