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  1. Small molecules are rising as a new generation of immune checkpoints’ inhibitors, with compounds targeting the human Programmed death-ligand 1 (hPD-L1) protein are pioneering this area of research. Promising e...

    Authors: Marawan Ahmed, Aravindhan Ganesan and Khaled Barakat
    Citation: BMC Chemistry 2022 16:49
    Content type: Research article Published on:

  3. Cancer is one of the most dangerous and widespread diseases in the world today and it has risen to the position of the leading cause of death around the globe in the last few decades. Due to the inherent resis...

    Authors: Mohammed Hawash, Nidal Jaradat, Ahmad M. Eid, Ahmad Abubaker, Ola Mufleh, Qusay Al-Hroub and Shorooq Sobuh
    Citation: BMC Chemistry 2022 16:47
    Content type: Research Published on:

  5. The magnetic nano-catalysts improve the contact between substrates and catalyst considerably and simple isolation of catalyst from reaction mixture. In this study, Fe3O4@nano-almondshell@OSi(CH2)3/2-(1-piperaziny...

    Authors: Dina Mallah and Bi Bi Fatemeh Mirjalili
    Citation: BMC Chemistry 2022 16:45
    Content type: Research Published on:

  6. A series of 2-aryl/alkyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines (S1–S11) were synthesized with an eco-friendly and recoverable nanocatalyst (GO-Fe3O4–Ti(IV)) as an efficient magnetic composite. The new nanoca...

    Authors: Soghra Khabnadideh, Aida solhjoo, Reza Heidari, Leila Amiri Zirtol, Amirhossein Sakhteman, Zahra Rezaei, Elaheh Babaei, Samaneh Rahimi and Leila Emami
    Citation: BMC Chemistry 2022 16:44
    Content type: Research Published on:

  7. Cellulose polymers with multidentate chelating functionalities that have high efficiency for toxic metal ions present in water were designed, synthesized, and analyzed. The synthesis was carried out by reactin...

    Authors: Noor Nairat, Othman Hamed, Avni Berisha, Shehdeh Jodeh, Manuel Algarra, Khalil Azzaoui, Omar Dagdag and Subhi Samhan
    Citation: BMC Chemistry 2022 16:43
    Content type: Research Published on:

  10. In this investigation, the azo dyes; 2-(3′-phenyl-5′-pyrazolyl azo) schaffer acid (la) and 2-(3′-phenyl-5′-pyrazolyl azo) resorcinol (Ib); were prepared through diazotizing 3-phenyl-5-aminopyrazole (PAP) and c...

    Authors: Fathy A. El-Seify, Hassan A. Azab, Fikrea S. Degedy, Khalid A. Abdel-Mageed and Farid I. El-Dossoki
    Citation: BMC Chemistry 2022 16:40
    Content type: Research Published on:

  11. Antibiotic resistance is a global problem. This is the reason why scientists search for alternative treatments. In this regard, seven novel silver chromite nanocomposites were synthesized and assayed to evalua...

    Authors: Mohsen A. Sayed, Tahany M. A. Abd El-Rahman, H. K. Abdelsalam, Ahmed M. Ali, Mayar M. Hamdy, Yara A. Badr, Nada H. Abd El- Rahman, Sabah M. Abd El-Latif, Sara H. Mostafa, Sondos S. Mohamed, Ziad M. Ali and Asmaa A. H. El-Bassuony
    Citation: BMC Chemistry 2022 16:39
    Content type: Research Published on:

  12. In this work, we have synthesized twenty five new 2-(5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one derivatives bearing an aryl or heteroaryl methylene group on position 5 of thiazolidinone...

    Authors: Arash Tabei, Ramona Ejtemaei, Arash Mahboubi, Parastoo Saniee, Alireza Foroumadi, Alireza Dehdari and Ali Almasirad
    Citation: BMC Chemistry 2022 16:38
    Content type: Research article Published on:

  13. In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out. Dowex 50WX8 adsorbent w...

    Authors: B. A. Masry, E. M. Abu Elgoud and S. E. Rizk
    Citation: BMC Chemistry 2022 16:37
    Content type: Research Published on:

  14. Malaria remains the major health problem responsible for many mortality and morbidity in developing countries. Because of the development of resistance by Plasmodium species, searching effective antimalarial agen...

    Authors: Yadessa Melaku, Melat Solomon, Rajalakshmanan Eswaramoorthy, Uwe Beifuss, Vladimir Ondrus and Yalemtsehay Mekonnen
    Citation: BMC Chemistry 2022 16:36
    Content type: Research Published on:

  15. Cancer is the most cause of morbidity and mortality, and a major public health problem worldwide. In this context, two series of quinazolinone 5a–e and dihydroquinazolinone 10a–f compounds were designed, synth...

    Authors: Fahimeh Taayoshi, Aida Iraji, Ali Moazzam, Meysam Soleimani, Mehdi Asadi, Keyvan Pedrood, Mosayeb Akbari, Hafezeh Salehabadi, Bagher Larijani, Neda Adibpour and Mohammad Mahdavi
    Citation: BMC Chemistry 2022 16:35
    Content type: Research Published on:

  17. A vortex-assisted dispersive liquid–liquid microextraction (DLLME) method, mated to chemometrics and combined with HPLC/UV detection was optimized and validated for enrichment and determination of repaglinide ...

    Authors: Amira H. Kamal, Mohamed A. Hammad, Reham E. Kannouma and Fotouh R. Mansour
    Citation: BMC Chemistry 2022 16:33
    Content type: Research Published on:

  18. The Pharmacy Service of the Infanta Leonor University Hospital acquires, compounds, distributes and dispenses more than 3000 L of methadone oral solution to Drug Addiction Patients Centers per year. Our purpos...

    Authors: Elena Alba Álvaro-Alonso, Mª Paz Lorenzo, Ismael Escobar-Rodríguez and Antonio Aguilar-Ros
    Citation: BMC Chemistry 2022 16:32
    Content type: Research Published on:

  20. Plants are good sources of various bioactive substances and have significant importance for the discovery of new drugs. In this study, Croton macrostachyus plant roots from six different sites in the Central Gond...

    Authors: Dessie T. Ayele, M. L. Akele and A. T. Melese
    Citation: BMC Chemistry 2022 16:30
    Content type: Research Published on:

  21. 4-Methylimidazole (4-MeI) or 4-methyl-1H-imidazole, a slightly yellowish solid with molecular formula C4H6N2, is a heterocyclic compound which supposedly does not exist as a natural product and is formed when car...

    Authors: Mahdiye Rafiei jam, Azizollah Nezhadali and Massoud Kaykhaii
    Citation: BMC Chemistry 2022 16:29
    Content type: Research Published on:

  22. A new, simple and selective HPLC method was implemented for the simultaneous estimation of tafluprost (TFL) and timolol (TIM) in their new anti-glaucoma combination in the challengeable ratio of 3 and 1000 for...

    Authors: Walaa Nabil Abd-AlGhafar, Fatma Ahmed Aly, Zeinab Awad Sheribah and Samar Saad
    Citation: BMC Chemistry 2022 16:28
    Content type: Research Published on:

  23. A zirconium-based metal-organic framework (Zr-MOF), named MOF-808, was synthesized and fully characterized by solvo-thermal method and functionalized by isonicotinic acid and employed as an efficient adsorbent...

    Authors: Marzieh Sharifi-Rad, Massoud Kaykhaii, Mostafa Khajeh and Alireza Oveisi
    Citation: BMC Chemistry 2022 16:27
    Content type: Research Published on:

  24. It is critical to take safety action if carcinogenic heavy metals and ammonia can be detected quickly, cheaply, and selectively in an environmental sample. As a result, compound 4a [4-(1-(2-(2,4-Dinitrophenyl)...

    Authors: Hanan A. Mohamed, Bakr F. Abdel-Wahab, Mahmoud N. M. Yousif and Reda M. Abdelhameed
    Citation: BMC Chemistry 2022 16:26
    Content type: Research article Published on:

  25. The present study introduces a high-efficiency nanocomposite material featuring a zinc-based metal–organic framework and a novel porous activated carbon derived from bread waste. The prepared nanocomposite, na...

    Authors: Yalda Pasandideh and Habib Razmi
    Citation: BMC Chemistry 2022 16:25
    Content type: Research article Published on:

  26. Impurity profiling of a pharmaceutical compound is now taking great attention during quality assessment of pharmaceuticals, as presence of small amount of impurities may affect safety and efficacy. In this wor...

    Authors: Khadiga M. Kelani, Maha A. Hegazy, Amal M. Hassan and Mahmoud A. Tantawy
    Citation: BMC Chemistry 2022 16:24
    Content type: Research article Published on:

  27. In this study Cu-chitosan nanoparticles (Cu-CNP) have been employed as eco-friendly and safer priming agents to induce salt and PEG-induced hyperosmotic stress tolerance in wheat seedlings. Seed priming is a f...

    Authors: Tahir Farooq, Zaib Un Nisa, Amjad Hameed, Toheed Ahmed and Arruje Hameed
    Citation: BMC Chemistry 2022 16:23
    Content type: Research article Published on:

  29. Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals...

    Authors: Muhammad Nawaz, Muhammad Waseem Abbasi, Marium Tariq, John Patrick Graham, Abdul-Rahman Saleh Al-Hagri, Ahmed Awad Elkarim, Muayad Elsiddig Mohamed, Veeranoot Nissapatorn, Muhammad Taha and Soleiman Hisaindee
    Citation: BMC Chemistry 2022 16:21
    Content type: Research article Published on:

  30. Prunella vulgaris is medicinally important plant containing high-valued chemical metabolites like Prunellin which belong to family Lamiaceae and it is also known as self-heal. In this research, calli culture were...

    Authors: Nisar Ahmad, Jan Muhammad, Khalil Khan, Wajid Ali, Hina Fazal, Mohammad Ali, Latif-ur Rahman, Hayat Khan, Muhammad Nazir Uddin, Bilal Haider Abbasi and Christophe Hano
    Citation: BMC Chemistry 2022 16:20
    Content type: Research article Published on:

  31. Type III beta phosphatidylinositol 4-kinase (PI4KIIIβ) is the only clinically validated drug target in Plasmodium kinases and therefore a critical target in developing novel drugs for malaria. Current PI4KIIIβ in...

    Authors: Akachukwu Ibezim, Mbanefo S. Madukaife, Sochi C. Osigwe, Nadja Engel, Ramanathan Karuppasamy and Fidele Ntie-Kang
    Citation: BMC Chemistry 2022 16:19
    Content type: Research article Published on:

  32. The ethyl 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate (1), a thiazole ester, was synthesized by refluxing 1-(2-nitrobenzylidene)thiosemicarbazide and ethyl bromopyruvate. The compound is characteri...

    Authors: Muhammad Haroon, Tashfeen Akhtar, Muhammad Yousuf, Muhammad Nawaz Tahir, Lubna Rasheed, Syeda Saniya Zahra, Ihsan ul Haq and Muhammad Ashfaq
    Citation: BMC Chemistry 2022 16:18
    Content type: Research article Published on:

  33. Human and veterinary antibiotics are typically discharged as parent chemicals in urine or feces and are known to be released into the environment via wastewater treatment plants (WWTPs). Several research inves...

    Authors: Shehdeh Jodeh, Ahlam Jaber, Ghadir Hanbali, Younes Massad, Zaki S. Safi, Smaail Radi, Valbonë Mehmeti, Avni Berisha, Said Tighadouini and Omar Dagdag
    Citation: BMC Chemistry 2022 16:17
    Content type: Research article Published on:

  35. An accurate, precise, sensitive, and simple spectroscopic method was developed and validated for simultaneous quantification analysis of tretinoin (TRT) and nicotinamide (NCT) with a ratio of 1:40 (TRT: NCT) i...

    Authors: Nazira Sarkis and Abdulkader Sawan
    Citation: BMC Chemistry 2022 16:15
    Content type: Research article Published on:

  38. In this research, a molecularly imprinted polymer (MIP) was synthesized and employed as a sorbent for pipette-tip micro solid phase extraction of profenofos insecticide in seawater, rice, and fish samples. The...

    Authors: Mahsa Tamandani, Sayyed Hossein Hashemi, Massoud Kaykhaii, Ahmad Jamali Keikha and Ali Nasiriyan
    Citation: BMC Chemistry 2022 16:12
    Content type: Research article Published on:

  39. Excess agrochemicals input from agricultural activities and industrial effluent around Lake Ziway catchment can pose a serious threat on the lake ecosystem. Lake Ziway is a shallow freshwater lake found in the...

    Authors: Dessie Tibebe, Feleke Zewge, Brook Lemma and Yezbie Kassa
    Citation: BMC Chemistry 2022 16:11
    Content type: Research article Published on:

  40. The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO3)2·3H2O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nit...

    Authors: Reza Akhavan-Sigari, Malihe Zeraati, Mohammadreza Moghaddam-Manesh, Parya Kazemzadeh, Sara Hosseinzadegan, Narendra Pal Singh Chauhan and Ghasem Sargazi
    Citation: BMC Chemistry 2022 16:10
    Content type: Research article Published on:

  41. A new, green and environmentally friendly protocol has been developed for the synthesis of tetrahydrodipyrazolopyridine derivatives. The structures of these products were determined in terms of melting point, ...

    Authors: Mina Keihanfar and Bi Bi Fatemeh Mirjalili
    Citation: BMC Chemistry 2022 16:9
    Content type: Research article Published on:

  42. A new diazo derivative of a pyrrolidine-2,5-dione (8) fused at position-3,4 to a dibenzobarrelene backbone has been prepared by coupling the previously reported N-arylsuccinimid (5) precursor with aryldiazonium i...

    Authors: Emmanuel Sopbué Fondjo, Abdou Salamou Njoya, Jean-de-Dieu Tamokou, Giscard Doungmo, Bruno Ndjakou Lenta, Peter F. W. Simon, Apollinaire Tsopmo and Jules-Roger Kuiate
    Citation: BMC Chemistry 2022 16:8
    Content type: Research Article Published on:

  43. The loss of cholinergic neurotransmission in Alzheimer's disease (AD) patients' brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinester...

    Authors: Maryam Taheri, Samira Aslani, Hossein Ghafouri, Asadollah Mohammadi, Vaha Akbary Moghaddam, Nastarn Moradi and Hananeh Naeimi
    Citation: BMC Chemistry 2022 16:7
    Content type: Research article Published on:

  45. Antibiotics are routinely used on poultry for therapy and prevention of diseases and to enhance animal growth. The objective of this study was to develop and validate a sensitive and reliable liquid chromatogr...

    Authors: Aynalem Lakew, Teshome Assefa, Meseret Woldeyohannes, Negussie Megersa and Bhagwan Singh Chandravanshi
    Citation: BMC Chemistry 2022 16:5
    Content type: Research article Published on:

  46. The reaction process of gaseous 1,3-butadiene following ultraviolet irradiation at the temperature range from 298 to 323 K under nitrogen atmosphere was monitored by UV–vis spectrophotometry. A gaseous mini-re...

    Authors: Min Liang, Chang Yu, Suyi Dai, Haijun Cheng, Weiguang Li, Fang Lai, Li Ma and Xiongmin Liu
    Citation: BMC Chemistry 2022 16:4
    Content type: Research article Published on:

  47. The subcontinent is famous for its variety of seasonal foods cooked in vegetable seed cooking oils at elevated heating. Oils are often of poor quality that effect to consumer health. The work, therefore, plann...

    Authors: Ayesha Baig, Muhammad Zubair, Sajjad Hussain Sumrra, Muhammad Faizan Nazar, Muhammad Nadeem Zafar, Kausar Jabeen, Muhammad Bilal Hassan and Umer Rashid
    Citation: BMC Chemistry 2022 16:3
    Content type: Research article Published on:

  48. Paracetamol compound remains the most used pharmaceutical as an analgesic and antipyretic for pain and fever, often identified in aquatic environments. The elimination of this compound from wastewater is one o...

    Authors: Sanae Tarhouchi, Rkia Louafy, El Houssine El Atmani and Miloudi Hlaïbi
    Citation: BMC Chemistry 2022 16:2
    Content type: Research Article Published on:

  49. Quinolines have demonstrated various biological activities such as antimalarial, antibacterial and anticancer. Hence, compounds with such scaffold have been used as lead in drug development. This project is, t...

    Authors: Mona Fekadu, Digafie Zeleke, Bayan Abdi, Anuradha Guttula, Rajalakshmanan Eswaramoorthy and Yadessa Melaku
    Citation: BMC Chemistry 2022 16:1
    Content type: Research article Published on:

  50. Thiazole-based Schiff base compounds display significant pharmacological potential with an ability to modulate the activity of many enzymes involved in metabolism. They also demonstrated to have antibacterial,...

    Authors: Fitsum Lemilemu, Mamaru Bitew, Taye B. Demissie, Rajalakshmanan Eswaramoorthy and Milkyas Endale
    Citation: BMC Chemistry 2021 15:67
    Content type: Research article Published on:
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BMC Chemistry

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