Articles

Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry

Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study atte...

Authors: Yulu Xie, Xican Li, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He and Dongfeng Chen

Evaluation of antioxidant profile of various solvent extracts of Carissa opaca leaves: an edible plant

Carissa opaca leaves were conventionally recommended by local hakims in Pakistan for curing various human diseases including renal, hepatic and jaundice. In this work we arranged to s...

Authors: Sumaira Sahreen, Muhammad Rashid Khan and Rahmat Ali Khan

Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

Authors: Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

Authors: Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

Bis-pyrimidine acetamides: design, synthesis and biological evaluation

In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

Authors: Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

Surface bound radicals, char yield and particulate size from the burning of tobacco cigarette

Tobacco smoke is a toxic gas-phase cocktail consisting of a broad range of organics, and free radical intermediates. The formation of smoke from a burning cigarette depends on a series of mechanisms, including...

Authors: Audriy Jebet, Joshua Kibet, Lucy Ombaka and Thomas Kinyanjui

Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions

Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts. Chamomile extracts have fou...

Authors: Maja Molnar, Nikolina Mendešević, Drago Šubarić, Ines Banjari and Stela Jokić

A comparative study of the metal binding behavior of alanine based bis-thiourea isomers

Two new symmetrical bis-thiourea, 2,2′-[{(terephthaloylbis(azanediyl)bis(carbonothioyl) bis(azanediyl)}dipropanoic acid] (1A) and 3,3′-[{(terephthaloylbis(azanediyl)bis (carbonothioyl)bis(azanediyl)} dipropano...

Authors: Imran Fakhar, Bohari M. Yamin and Siti Aishah Hasbullah

Directed Assembly Network phase three launch: a round-up of success to date and strategy for the future

To showcase the Networks’ success during phase two (2012–2016), and to set out the strategy for phase three (2017–2019), the Directed Assembly Network held a meeting at the Royal Society in London, United King...

Authors: J. A. R. Rose, P. R. Raithby and C. Makatsoris

Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

Authors: Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

Authors: Li Zhou, Xu Zhang and Wen Zhou

Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, s...

Authors: David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten and Ajit K. Basak

Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

Authors: Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

The directed assembly grand challenge network

Authors: J. A. R. Rose, P. R. Raithby and C. Makatsoris

Structural effects on kinetics and a mechanistic investigation of the reaction between DMAD and N–H heterocyclic compound in the presence of triphenylarsine: spectrophotometry approach

Kinetics and a mechanistic investigation of the reaction between dimethyl acetylenedicarboxcylate (DMAD) and saccharin (N–H heterocyclic compound) has been spectrally studied in methanol environment in the presen...

Authors: Sayyed Mostafa Habibi-Khorassani, Mehdi Shahraki and Mahdieh Darijani

Erratum to: One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

Authors: Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

Multi drug-resistant and mycobacterial infections are a major public health challenge, leading to high mortality and socioeconomic burdens through worldwide. Novel therapeutics are necessary to treat the drug ...

Authors: Mohana Rao Anguru, Ashok Kumar Taduri, Rama Devi Bhoomireddy, Malathi Jojula and Shravan Kumar Gunda

Fingerprint analysis of Resina Draconis by ultra-performance liquid chromatography

Resina Draconis, a bright red resin derived from Dracaena cochinchinensis, is a traditional medicine used in China. To improve its quality control approach, an ultra-performance liquid chromatography (UPLC) finge...

Authors: Yudi Xue, Lin Zhu and Tao Yi

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

Authors: Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

RD-Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug-like molecules

Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational ...

Authors: Jiajia Meng, Shiliang Li, Xiaofeng Liu, Mingyue Zheng and Honglin Li

Comparative study of phenolic compounds, vitamin E, and fatty acids compositional profiles in black seed-coated soybeans (Glycine Max (L.) Merrill) depending on pickling period in brewed vinegar

Pickled soybeans or vinegar beans have long been used as a folk remedy and also a supplemental nutritional source in Korea. In general the pickling process in vinegar improves the digestibility of soybeans as ...

Authors: Ill-Min Chung, Jin-Young Oh and Seung-Hyun Kim

Using crystallography, topology and graph set analysis for the description of the hydrogen bond network of triamterene: a rational approach to solid form selection

This study has demonstrated the use of crystallography, topology and graph set analysis in the description and classification of the complex hydrogen bonded network of triamterene. The aim is to give a brief o...

Authors: David S. Hughes, Amit Delori, Abida Rehman and William Jones

The mechanism for enhanced oxidation degradation of dioxin-like PCBs (PCB-77) in the atmosphere by the solvation effect

The reaction pathways of PCB-77 in the atmosphere with ·OH, O₂, NO _x , and ¹O₂ were inferred based on density functional theory calculations with the 6-31G* basis set. The struct...

Authors: Mei-Ling Xin, Jia-Wen Yang and Yu Li

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance ...

Authors: Wenyi Zhu, Yijie Du, Hong Meng, Yinmao Dong and Li Li

A validated stability-indicating HPLC method for determination of brimonidine tartrate in BRI/PHEMA drug delivery systems

A simple, rapid and accurate stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) was developed and validated for the determination of brimonidine tartrate in brimonidine tartrat...

Authors: Jianguo Sun, Xiuwen Zhang and Taomin Huang

Selective synthesis of Fe₃O₄Au _x Ag _y nanomaterials and their potential applications in catalysis and nanomedicine

In these recent years, magnetite (Fe₃O₄) has witnessed a growing interest in the scientific community as a potential material in various fields of application namely in catalysis, biosensing, hyperthermia treatme...

Authors: Essy Kouadio Fodjo, Koffi Mouroufié Gabriel, Brou Yapi Serge, Dan Li, Cong Kong and Albert Trokourey

Comparative studies on phenolic profiles, antioxidant capacities and carotenoid contents of red goji berry (Lycium barbarum) and black goji berry (Lycium ruthenicum)

The study on phytochemical difference between red and black goji berry is limited.

Authors: Tahidul Islam, Xiaoming Yu, Tanvir Singh Badwal and Baojun Xu

Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway

The black turtle bean (BTB) is most widely consumed legume all over the world having anticancer activity. The aim of the study was to analyse the apoptotic effects of BTB extracts on human breast cancer cell l...

Authors: Suresh Kumar, Vinay Kumar Sharma, Savita Yadav and Sharmistha Dey

Utility of 2-thioxo-pyrido[2,3-d]pyrimidinone in synthesis of pyridopyrimido[2,1-b][1,3,5]-thiadiazinones and pyridopyrimido[2,1-b][1,3]thiazinones as antimicrobial agents

Pyridopyrimidines are of current interest because of their extensive variety of biological and pharmacological activities.

Authors: Yasser H. Zaki, Sobhi M. Gomha and Amany M. G. Mohamed

Hemostatic chemical constituents from natural medicine Toddalia asiatica root bark by LC-ESI Q-TOF MS^E

Toddalia asiatica root bark as an effective hemostatic natural medicine or Chinese materia medica was applied in China for long history, its complex drug action mechanisms and unclear ...

Authors: Xiaoyan Zhang, Wenbo Sun, Zhou Yang, Yan Liang, Wei Zhou and Lei Tang

Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology

Clinacanthus nutans Lindau is a well-known plant, native to tropical Asian countries. Reports on this plant that is rich in phenolic compounds have focused on its therapeutic anti-infl...

Authors: Intan Soraya Che Sulaiman, Mahiran Basri, Hamid Reza Fard Masoumi, Wei Jian Chee, Siti Efliza Ashari and Maznah Ismail

Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of ...

Authors: Nadia A. Abdelriheem, Yasser H. Zaki and Abdou O. Abdelhamid

Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues

Pyrimidine is an aromatic heterocyclic moiety containing nitrogen atom at 1st and 3rd positions and play an important role to forms the central core for different necessity of biological active compounds, from...

Authors: Sangeeta Narwal, Sanjiv Kumar and Prabhakar Kumar Verma

Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties

Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibac...

Authors: Yahia N. Mabkhot, Salim S. Al-Showiman, Saied M. Soliman, Hazem A. Ghabbour, Murad A. AlDamen and Mohammad S. Mubarak

Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-y...

Authors: Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, Chuanhui Li, A’li Dai, Zhiqian Liu, Jiahong Xu, Fenghua Wang and Jian Wu

Morphologically controlled synthesis of ferric oxide nano/micro particles and their catalytic application in dry and wet media: a new approach

Morphologically controlled synthesis of ferric oxide nano/micro particles has been carried out by using solvothermal route. Structural characterization displays that the predominant morphologies are porous hol...

Authors: Muhammad Ramzan Saeed Ashraf Janjua, Saba Jamil, Nazish Jahan, Shanza Rauf Khan and Saima Mirza

Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents

The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc.

Authors: Danah S. Al-Shamary, Monirah A. Al-Alshaikh, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot and Syed Lal Badshah

Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery

Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of...

Authors: Muhammad Sani Usman, Mohd Zobir Hussein, Sharida Fakurazi and Fathinul Fikri Ahmad Saad

Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for...

Authors: Sawsan M. Amer, Adnan A. Kadi, Hany W. Darwish and Mohamed W. Attwa

Synthesis of carboxymethylcellulose/starch superabsorbent hydrogels by gamma-irradiation

Superabsorbent hydrogels show a large potential in a wide array of applications due to their unique properties. Carboxymethylcellulose (CMC) is a commercially available water-soluble cellulose derivative of ma...

Authors: Tamás Fekete, Judit Borsa, Erzsébet Takács and László Wojnárovits

Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology

Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivat...

Authors: Somayeh Gholivand, Ola Lasekan, Chin Ping Tan, Faridah Abas and Leong Sze Wei

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different no...

Authors: Ekram H. Mohamed, Hayam M. Lotfy, Maha A. Hegazy and Shereen Mowaka

Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a–t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

Authors: Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

Authors: Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands

Four novel complexes [Co(H₂O)₄(sul)₂] 1, [Co(2-ampy)₂(sul)₂] 2, [Co(H₂O)₂(1,10-phen) (sul)₂] 3 and [Co(2,9-dimephen)(sul)₂] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-di...

Authors: Asia M. Shalash and Hijazi I. Abu Ali

Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity

Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

Authors: Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

Application of a strategy based on metabolomics guided promoting blood circulation bioactivity compounds screening of vinegar

Rice vinegar (RV) and white vinegar (WV) as daily flavoring, have also used as accessory in traditional Chinese medicine processing. As we know, the promoting blood circulation efficiency could be enhanced whe...

Authors: Zhangchi Ning, Zhenli Liu, Zhiqian Song, Chun Wang, Yuanyan Liu, Jiahe Gan, Xinling Ma and Aiping Lu

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities.

Authors: Sobhi M. Gomha, Mastoura M. Edrees, Rasha A. M. Faty, Zeinab A. Muhammad and Yahia N. Mabkhot

Rapid simultaneous determination of indacaterol maleate and glycopyrronium bromide in inhaler capsules using a validated stability-indicating monolithic LC method

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. A combination of indacaterol maleate with glycopyrronium bromide has recently been approved as a once-daily m...

Authors: Sahar Zayed and Fathalla Belal

Effect of molybdenum and tungsten on the reduction of nitrate in nitrate reductase, a DFT study

The molybdenum and tungsten active site model complexes, derived from the protein X-ray crystal structure of the first W-containing nitrate reductase isolated from Pyrobaculum aerophilum, were computed for nitrat...

Authors: Uzma Habib and Matthias Hoffman