Articles

Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents

Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some p...

Authors: Parvin Kumar, Kulbir Kadyan, Meenakshi Duhan, Jayant Sindhu, Vineeta Singh and Baljeet Singh Saharan

Simultaneous determination of brazilin and protosappanin B in Caesalpinia sappan by ionic-liquid dispersive liquid-phase microextraction method combined with HPLC

The conditions of heating, ionic liquid-based ultrasonic-assisted extraction combined with reverse-phase high performance liquid chromatography were optimized to simultaneously isolate and determinate brazilin...

Authors: Zhaoyang Xia, Dongdong Li, Qing Li, Yan Zhang and Wenyi Kang

Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.

Many Geum species are known to be rich in biologically active compounds and therefore could be a source of new natural products with pharmacological potential. The medicinal plant Geum urbanum L. is widespread in...

Authors: Lyudmila Dimitrova, Maya M. Zaharieva, Milena Popova, Nedelina Kostadinova, Iva Tsvetkova, Vassya Bankova and Hristo Najdenski

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivative...

Authors: Mohamed A. M. Abdel Reheim and Safaa M. Baker

Aromatherapy: composition of the gaseous phase at equilibrium with liquid bergamot essential oil

This work compares the composition at different temperatures of gaseous phase of bergamot essential oil at equilibrium with the liquid phase. A new GC–MS methodology to determine quantitatively the volatile ar...

Authors: Antonella Leggio, Vanessa Leotta, Emilia Lucia Belsito, Maria Luisa Di Gioia, Emanuela Romio, Ilaria Santoro, Domenico Taverna, Giovanni Sindona and Angelo Liguori

Antioxidant and antiproliferative activity of blue corn and tortilla from native maize

Blue corn is a cereal rich in phenolic compounds used to make blue tortillas. Tortillas are an important part of the Mexican diet. Blue corn and tortilla represent an important source of the natural antioxidan...

Authors: Mónica Y. Herrera-Sotero, Carlos D. Cruz-Hernández, Carolina Trujillo-Carretero, Mauricio Rodríguez-Dorantes, Hugo S. García-Galindo, José L. Chávez-Servia, Rosa M. Oliart-Ros and Rosa I. Guzmán-Gerónimo

Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation

A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds we...

Authors: Min Peng, Liqiao Shi and Shaoyong Ke

Rapid recovery of high content phytosterols from corn silk

Phytosterols have important physiological and officinal function.

Authors: Haiyan Zhang, Xiaowan Cao, Yong Liu and Fude Shang

Preparative HPLC for large scale isolation, and salting-out assisted liquid–liquid extraction based method for HPLC–DAD determination of khat (Catha edulis Forsk) alkaloids

Khat (Catha edulis Forsk) is an evergreen shrub of the Celastraceae family. It is widely cultivated in Yemen and East Africa, where its fresh leaves are habitually chewed for their momentary pleasures and stimula...

Authors: Minaleshewa Atlabachew, Bhagwan Singh Chandravanshi and Mesfin Redi-Abshiro

Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myr...

Authors: Xinmin Zhong, Xiaobin Wang, Lijuan Chen, Xianghui Ruan, Qin Li, Juping Zhang, Zhuo Chen and Wei Xue

A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents

Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities.

Authors: Sobhi M. Gomha, Mohamad R. Abdelaziz, Nabila A. Kheder, Hassan M. Abdel-aziz, Seham Alterary and Yahia N. Mabkhot

Modification and comparison of three Gracilaria spp. agarose with methylation for promotion of its gelling properties

In order to improve the gelling properties of agarose, we modified it by methylation. The agarose was prepared from Gracilaria asiatica, G. bailinae, and G. lemaneiformis with alkaline, treated with diatomaceous ...

Authors: Yangyang Gu, Kit-Leong Cheong and Hong Du

Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular...

Authors: Hatem A. Abuelizz, Rashad Al-Salahi, Jamil Al-Asri, Jérémie Mortier, Mohamed Marzouk, Essam Ezzeldin, Azza A. Ali, Mona G. Khalil, Gerhard Wolber, Hazem A. Ghabbour, Abdulrahman A. Almehizia and Gehad A. Abdel Jaleel

Synthesis and anticancer activity of novel quinazolinone-based rhodanines

Rhodanines and quinazolinones have been reported to possess various pharmacological activities.

Authors: Sherihan El-Sayed, Kamel Metwally, Abdalla A. El-Shanawani, Lobna M. Abdel-Aziz, Harris Pratsinis and Dimitris Kletsas

Steam distillation/drop-by-drop extraction with gas chromatography–mass spectrometry for fast determination of volatile components in jujube (Ziziphus jujuba Mill.) extract

Jujube extract is commonly used as a food additive and flavoring. The unique jujube aroma and the mild sweet aroma of the extract are critical factors that determine product quality and affect consumer accepta...

Authors: Shi-Hao Sun, Guo-Bi Chai, Peng Li, Jian-Ping Xie and Yue Su

MOF the beaten track: unusual structures and uncommon applications of metal–organic frameworks

Over the past few decades, metal–organic frameworks (MOFs) have proved themselves as strong contenders in the world of porous materials, standing alongside established classes of compounds such as zeolites and...

Authors: Alexander J. Tansell, Corey L. Jones and Timothy L. Easun

Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

The combination between cetirizine (CET), phenylpropanolamine (PPA) and nimesulide (NMS) under trade name Nemeriv Cp tablet is prescribed for nasal congestion, cold, sneezing, and allergy. Among all published ...

Authors: Fatma Ahmed Aly, Nahed EL-Enany, Heba Elmansi and Amany Nabil

Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum Ait flowers

In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot wa...

Authors: Zhenhua Yin, Wei Zhang, Juanjuan Zhang and Wenyi Kang

Acidic and enzymatic saccharification of waste agricultural biomass for biotechnological production of xylitol

The plant biomass and agro-industrial wastes show great potential for their use as attractive low cost substrates in biotechnological processes. Wheat straw and corn cob as hemicellulosic substrates were acid ...

Authors: Abdul Ghaffar, Muhammad Yameen, Nosheen Aslam, Fatima Jalal, Razia Noreen, Bushra Munir, Zahed Mahmood, Sadaf Saleem, Naila Rafiq, Sadia Falak, Imtiaz Mahmood Tahir, Muhammad Noman, Muhammad Umar Farooq, Samina Qasim and Farooq Latif

Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80–120 min), temperature (60–80 °C) and ethanol concentration (70–90 v/v...

Authors: Nur Fauwizah Azahar, Siti Salwa Abd Gani and Nor Fadzillah Mohd Mokhtar

A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.)

The sunflower (Helianthus annuus L.) seed and sprout is a ubiquitous crop with abundant nutrients and biological activities. This review summarizes the nutritional and medical importance currently recognized but ...

Authors: Shuangshuang Guo, Yan Ge and Kriskamol Na Jom

Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents

12N-benzyl matrinic acid analogues had been identified to be a novel scaffold of anti-HCV agents with a specific mechanism, and the representative compound 1 demonstrated a moderate anti-HCV activity. The intensi...

Authors: Sheng Tang, Zong-Gen Peng, Ying-Hong Li, Xin Zhang, Tian-Yun Fan, Jian-Dong Jiang, Yan-Xiang Wang and Dan-Qing Song

Characterization and quantification of flavonoids and saponins in adzuki bean (Vigna angularis L.) by HPLC–DAD–ESI–MSⁿ analysis

Bioactive activities of adzuki bean have been widely reported, however, the phytochemical information of adzuki bean is incomplete. The aim of this study was to characterize and quantify flavonoids and saponin...

Authors: Rui Liu, Zongwei Cai and Baojun Xu

Phenolic compounds, flavonoids, lipids and antioxidant potential of apricot (Prunus armeniaca L.) pomace fermented by two filamentous fungal strains in solid state system

The use of agricultural and food by-products is an economical solution to industrial biotechnology. The apricot press residues are abounding by-products from juice industry which can be used as substrates in s...

Authors: Francisc Vasile Dulf, Dan Cristian Vodnar, Eva-Henrietta Dulf and Adela Pintea

Erratum to: One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

Authors: Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

Reversible uptake of molecular oxygen by heteroligand Co(II)–l-α-amino acid–imidazole systems: equilibrium models at full mass balance

The paper examines Co(II)–amino acid–imidazole systems (where amino acid = l-α-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintai...

Authors: Marek Pająk, Magdalena Woźniczka, Andrzej Vogt and Aleksander Kufelnicki

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives

Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. A series of bis-pyrimidine Schiff bases were ...

Authors: Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Manikandan Selvaraj and Balasubramanian Narasimhan

Novel pyridine-based Pd(II)-complex for efficient Suzuki coupling of aryl halides under microwaves irradiation in water

Suzuki C–C cross-coupling of aryl halides with aryl boronic acids using new phosphene-free palladium complexes as precatalysts was investigated. A pyridine-based Pd(II)-complex was used in open air under therm...

Authors: Ismail I. Althagafi, Mohamed R. Shaaban, Aisha Y. Al-dawood and Ahmad M. Farag

Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl₄

A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl₄ is reported. The amidation reaction was performed in pyridine at 85 °C with a wi...

Authors: Antonella Leggio, Jessica Bagalà, Emilia Lucia Belsito, Alessandra Comandè, Marianna Greco and Angelo Liguori

The development of an effective synthetic route of lesinurad (RDEA594)

Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic rou...

Authors: Qing Meng, Tong Zhao, Dongwei Kang, Boshi Huang, Peng Zhan and Xinyong Liu

Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids

A series of six novel benzimidazole-pyrazole hybrid molecules was synthesized and characterized using elemental analysis (CHN) and spectroscopic methods (¹HNMR, FT-IR). All the synthesized compounds were evaluate...

Authors: Abida Noor, Neelum Gul Qazi, Humaira Nadeem, Arif-ullah Khan, Rehan Zafar Paracha, Fawad Ali and Adil Saeed

Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry

Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study atte...

Authors: Yulu Xie, Xican Li, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He and Dongfeng Chen

Evaluation of antioxidant profile of various solvent extracts of Carissa opaca leaves: an edible plant

Carissa opaca leaves were conventionally recommended by local hakims in Pakistan for curing various human diseases including renal, hepatic and jaundice. In this work we arranged to s...

Authors: Sumaira Sahreen, Muhammad Rashid Khan and Rahmat Ali Khan

Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

Authors: Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

Authors: Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

Bis-pyrimidine acetamides: design, synthesis and biological evaluation

In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

Authors: Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

Surface bound radicals, char yield and particulate size from the burning of tobacco cigarette

Tobacco smoke is a toxic gas-phase cocktail consisting of a broad range of organics, and free radical intermediates. The formation of smoke from a burning cigarette depends on a series of mechanisms, including...

Authors: Audriy Jebet, Joshua Kibet, Lucy Ombaka and Thomas Kinyanjui

Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions

Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts. Chamomile extracts have fou...

Authors: Maja Molnar, Nikolina Mendešević, Drago Šubarić, Ines Banjari and Stela Jokić

Directed Assembly Network phase three launch: a round-up of success to date and strategy for the future

To showcase the Networks’ success during phase two (2012–2016), and to set out the strategy for phase three (2017–2019), the Directed Assembly Network held a meeting at the Royal Society in London, United King...

Authors: J. A. R. Rose, P. R. Raithby and C. Makatsoris

A comparative study of the metal binding behavior of alanine based bis-thiourea isomers

Two new symmetrical bis-thiourea, 2,2′-[{(terephthaloylbis(azanediyl)bis(carbonothioyl) bis(azanediyl)}dipropanoic acid] (1A) and 3,3′-[{(terephthaloylbis(azanediyl)bis (carbonothioyl)bis(azanediyl)} dipropano...

Authors: Imran Fakhar, Bohari M. Yamin and Siti Aishah Hasbullah

Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

Authors: Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

Authors: Li Zhou, Xu Zhang and Wen Zhou

Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, s...

Authors: David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten and Ajit K. Basak

Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

Authors: Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

Structural effects on kinetics and a mechanistic investigation of the reaction between DMAD and N–H heterocyclic compound in the presence of triphenylarsine: spectrophotometry approach

Kinetics and a mechanistic investigation of the reaction between dimethyl acetylenedicarboxcylate (DMAD) and saccharin (N–H heterocyclic compound) has been spectrally studied in methanol environment in the presen...

Authors: Sayyed Mostafa Habibi-Khorassani, Mehdi Shahraki and Mahdieh Darijani

The directed assembly grand challenge network

Authors: J. A. R. Rose, P. R. Raithby and C. Makatsoris

Erratum to: One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

Authors: Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

Multi drug-resistant and mycobacterial infections are a major public health challenge, leading to high mortality and socioeconomic burdens through worldwide. Novel therapeutics are necessary to treat the drug ...

Authors: Mohana Rao Anguru, Ashok Kumar Taduri, Rama Devi Bhoomireddy, Malathi Jojula and Shravan Kumar Gunda

Fingerprint analysis of Resina Draconis by ultra-performance liquid chromatography

Resina Draconis, a bright red resin derived from Dracaena cochinchinensis, is a traditional medicine used in China. To improve its quality control approach, an ultra-performance liquid chromatography (UPLC) finge...

Authors: Yudi Xue, Lin Zhu and Tao Yi

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

Authors: Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek