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  1. A novel series of 4-nitrophenylpiperazine derivatives (4am) was designed and synthesized as potential tyrosinase inhibitors. Comprehensive characterization using 1H-NMR, 13C-NMR, CNH, and IR techniques was perfo...

    Authors: Mehdi Asadi, Fahime Fayazi, Aida Iraji, Reyhaneh Sabourian, Homa Azizian, Mannan Hajimahmoodi, Bagher Larijani, Mohammad Mahdavi and Massoud Amanlou
    Citation: BMC Chemistry 2024 18:67
  2. In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular hybridization theory, a novel series of isoindolin-1,3-dione-based acetohydrazides (compounds 8ah) was designed, synthesized, and ...

    Authors: Ahmad Nazarian, Fahime Abedinifar, Haleh Hamedifar, Mohammad Hashem Hashempur, Mohammad Mahdavi, Nima Sepehri and Aida Iraji
    Citation: BMC Chemistry 2024 18:64
  3. In this research, a novel magnetic zirconium-based metal-organic framework (Fe3O4@SiO2@MIP-202, MMOF), was fabricated, fully characterized, and applied for the batch-mode solid phase extraction of trace amounts o...

    Authors: Amin Piri, Massoud Kaykhaii, Mostafa Khajeh and Ali Reza Oveisi
    Citation: BMC Chemistry 2024 18:63
  4. A rapid and efficient analytical method was established to quantify indoxyl sulfate (IS) in plasma through extraction technique with a deep eutectic solvent (DES) and spectrofluorimetric method. DES (choline c...

    Authors: Samira Shafiee, Siavoush Dastmalchi, Afshin Gharekhani and Ali Shayanfar
    Citation: BMC Chemistry 2024 18:61
  5. Phytochemical investigation of Key lime (Citrus aurantifolia L., F. Rutaceae) peels afforded six metabolites, known as methyl isolimonate acetate (1), limonin (2), luteolin (3), 3ˋ-hydroxygenkwanin (4), myricetin...

    Authors: Abeer H. Elmaidomy, Usama Ramadan Abdelmohsen, Ahmed M. Sayed, Faisal H. Altemani, Naseh A. Algehainy, Denisa Soost, Thomas Paululat, Gerhard Bringmann and Esraa M. Mohamed
    Citation: BMC Chemistry 2024 18:60
  6. Lung cancer is a disease with a high mortality rate and it is the number one cause of cancer death globally. Approximately 12–14% of non-small cell lung cancers are caused by mutations in KRASG12C. The KRASG12C i...

    Authors: Amar Ajmal, Hind A Alkhatabi, Roaa M. Alreemi, Mubarak A. Alamri, Asaad Khalid, Ashraf N. Abdalla, Bader S. Alotaibi and Abdul Wadood
    Citation: BMC Chemistry 2024 18:57
  7. Gold and silver nanoparticles have witnessed increased scientific interest due to their colourful colloidal solutions and exceptional applications. Comparing the localized surface plasmon resonance (LSPR) of g...

    Authors: Khadiga M. Kelani, Maha M. Ibrahim, Nesreen K. Ramadan, Eman S. Elzanfaly and Sherif M. Eid
    Citation: BMC Chemistry 2024 18:56
  8. Plasmodium falciparum is the most lethal malaria parasite. P. falciparum Hsp70 (PfHsp70) is an essential molecular chaperone (facilitates protein folding) and is deemed a prospective antimalarial drug target. The...

    Authors: Francis Opoku, Penny Govender, Addmore Shonhai and Mthokozisi BC Simelane
    Citation: BMC Chemistry 2024 18:55
  9. Montelukast sodium (MLK) and Levocetirizine dihydrochloride (LCZ) are widely prescribed medications with promising therapeutic potential against COVID-19. However, existing analytical methods for their quantif...

    Authors: Noha S. Katamesh, Ahmed Emad F. Abbas and Shimaa A. Mahmoud
    Citation: BMC Chemistry 2024 18:54
  10. This study encompasses a quick, efficient, repeatable and reproducible analytical method for simultaneous determination of Bromoxynil (3, 5-Dibromo-4-hydroxybenzonitrile) and MCPA (2-methyl-4-chlorophenoxyacet...

    Authors: Ahmed Yar, Tariq Mahmood Ansari, Faariah Rehman, Asad Raza, Umair Riaz, Rashid Iqbal, Amal M. Al-Mohaimeed, Wedad A. Al-onazi and Muhammad Rizwan
    Citation: BMC Chemistry 2024 18:53
  11. Various sets of thiazole, thiophene, and 2-pyridone ring structures containing a dimethylaniline component were synthesized. Substituted thiazoles 23 and thiophenes 57 were produced by reacting thiocarbamoyl co...

    Authors: Heba M. Metwally, Norhan M. Younis, Ehab Abdel-Latif and Ali El-Rayyes
    Citation: BMC Chemistry 2024 18:52
  12. This work focuses on physicochemical features of the choline chloride/propylene glycol deep eutectic solvent (DES) + water mixtures by determining their density values in mono- and mixed- states over various t...

    Authors: Aynaz Zarghampour, Parisa Jafari, Elaheh Rahimpour and Abolghasem Jouyban
    Citation: BMC Chemistry 2024 18:51
  13. The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19 infections in early diagnosed patients. The main objective of t...

    Authors: Sara I. Aboras, Ahmed A. Megahed, Fawzy El-Yazbi and Hadir M. Maher
    Citation: BMC Chemistry 2024 18:50
  14. Pholcodine, an anti-tussive medication widely used as an over-the-counter, OTC drug, has recently faced restrictions in several countries. This paper presents a sensitive electrochemical approach for pholcodin...

    Authors: Nahla A. Abdelshafi, Hany W. Darwish, Ashwag S. Alanazi, Ibrahim A. Naguib, Hadeer H. Elkhouly, Nehal S. Khodary and Ekram H. Mohamed
    Citation: BMC Chemistry 2024 18:48
  15. In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, elemental and HRMS analysis. The compounds were e...

    Authors: Hafiz Muhammad Attaullah, Syeda Abida Ejaz, Pervaiz Ali Channar, Aamer Saeed, Rabail Ujan, Seema Zargar, Sajid Ali Channar, Reshma Sahito, Tanveer A. Wani and Qamar Abbas
    Citation: BMC Chemistry 2024 18:47
  16. Pest disasters which occurs on crops is a serious problem that not only cause crop yield loss or even crop failure but can also spread a number of plant diseases.Sulfonate derivatives have been widely used in ...

    Authors: You-hua Liu, Chang-kun Li, Mao-yu Nie, Fa-li Wang, Xiao-li Ren, Lin-hong Jin and Xia Zhou
    Citation: BMC Chemistry 2024 18:46
  17. The present study investigates the potential of a new compound containing sulfonamide and 4(3H)-quinazolinone to inhibit the hCA-IIX enzyme using in silico methods. Density functional theory-based calculations...

    Authors: Ahmed M. Alkaoud, Abbas I. Alakhras, Moez A. Ibrahim, S. K. Alghamdi and Rageh K. Hussein
    Citation: BMC Chemistry 2024 18:45
  18. A multivariate spectrophotometric method is a potential approach that enables discrimination of spectra of components in complex matrices (e.g., pharmaceutical formulation) serving as a substitution method for...

    Authors: Aya A. Mouhamed, Ahmed H. Nadim, Nadia M. Mostafa and Basma M. Eltanany
    Citation: BMC Chemistry 2024 18:44
  19. The objective of this research was to prepare some Fe3O4@SiO2@Chitosan (CS) magnetic nanocomposites coupled with nisin, and vancomycin to evaluate their antibacterial efficacy under both in vitro and in vivo agai...

    Authors: Mona Nasaj, Abbas Farmany, Leili Shokoohizadeh, Farid Aziz Jalilian, Reza Mahjoub, Ghodratollah Roshanaei, Alireza Nourian, Omid Heydari Shayesteh and Mohammadreza Arabestani
    Citation: BMC Chemistry 2024 18:43
  20. A receptor-based pharmacophore model describing the binding features required for the multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, and BRAF) were constructed and validated. It showed a good ...

    Authors: Heba T. Abdel-Mohsen, Marwa A. Ibrahim, Amira M. Nageeb and Ahmed M. El Kerdawy
    Citation: BMC Chemistry 2024 18:42
  21. A novel series of kojic acid fused 2-amino-3-cyano-4H-pyran derivatives were synthesized via a multicomponent reaction involving kojic acid, benzyloxy benzaldehyde, and malonitrile as tyrosinase inhibitors. Su...

    Authors: Zahra Najafi, Maryam Zandi Haramabadi, Gholamabbas Chehardoli, Ahmad Ebadi‬ and Aida Iraji
    Citation: BMC Chemistry 2024 18:41
  22. Four sensitive and fast analytical approaches relied on ion pairing with eosin Y were built up and evaluated using spectroscopy for determination of Alcaftadine and Olopatadine hydrochloride with high sensitiv...

    Authors: Sayed M. Derayea, Khalid M. Badr El-din, Ahmed S. Ahmed, Ahmed A. Khorshed and Mohamed Oraby
    Citation: BMC Chemistry 2024 18:40
  23. Anti-cancer peptides (ACPs) are short peptides known for their ability to inhibit tumor cell proliferation, migration, and the formation of tumor blood vessels. In this study, we designed ACPs to target recept...

    Authors: Aisha Naeem, Nighat Noureen, Shaikha Khalid Al-Naemi, Jawaher Ahmed Al-Emadi and Muhammad Jawad Khan
    Citation: BMC Chemistry 2024 18:39
  24. The α-bromination reaction of carbonyl compounds is a significant topic in the field of organic chemistry. However, due to the lack of suitable brominating reagents, the application of this reaction in undergr...

    Authors: Yongguang Gao, Na Chen, Xiaoye Jiang and Xiaochun Yang
    Citation: BMC Chemistry 2024 18:38
  25. Broad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clinical treatment. The purpose of this study ...

    Authors: Yige Yu, Jinyu Hu, Xiaohai Chen, Hua-lu Wu, Anzhou Wang and Congrong Tang
    Citation: BMC Chemistry 2024 18:37
  26. Patients diagnosed with symptomatic peripheral artery disease (PAD) in the lower extremities have a higher likelihood of suffering from major vascular events. Recently, FDA has approved the combination therapy...

    Authors: Heba M. Mohamed and Hebatallah M. Essam
    Citation: BMC Chemistry 2024 18:36
  27. Nanocomposites incorporating titanium dioxide (TiO2) have a significant potential for various industrial and medical applications. These nanocomposites exhibit selectivity as antimicrobial and anticancer agents. ...

    Authors: Rana R. El Sadda, Mai S. Eissa, Rokaya K. Elafndi, Elhossein A. Moawed, Mohamed M. El-Zahed and Hoda R. Saad
    Citation: BMC Chemistry 2024 18:35
  28. In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The...

    Authors: Eman M. Sayed, Etify A. Bakhite, Reda Hassanien, Nasser Farhan, Hanan F. Aly, Salma G. Morsy and Nivin A. Hassan
    Citation: BMC Chemistry 2024 18:34
  29. Magnetic nanoparticles can be considered a reliable tool for targeted drug delivery to cancer tissues. Based on this, in this study, the anticancer effect of iron oxide nanoparticles coated with glucose and co...

    Authors: Somayeh Mikaeili Ghezeljeh, Ali Salehzadeh and Somayeh Ataei-e Jaliseh
    Citation: BMC Chemistry 2024 18:33
  30. A novel series of 1-(5-((6-nitroquinazoline-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives 8 were designed and synthesized to evaluate their cytotoxic potencies. The structures of these obtained compo...

    Authors: Sara Masoudinia, Marjaneh Samadizadeh, Maliheh Safavi, Hamid Reza Bijanzadeh and Alireza Foroumadi
    Citation: BMC Chemistry 2024 18:30
  31. VEGFR2 and FAK signaling pathways are interconnected and have synergistic effects on tumor angiogenesis, growth, and metastasis. Thus, instead of the conventional targeting of each of these proteins individual...

    Authors: Marwa A. Fouad, Alaa A. Osman, Noha M. Abdelhamid, Mai W. Rashad, Ashrakat Y. Nabawy and Ahmed M. El Kerdawy
    Citation: BMC Chemistry 2024 18:29
  32. A facile, sensitive, accurate and green spectrofluorimetric method was evolved for the assay of ciprofloxacin hydrochloride (CFX) and phenylephrine hydrochloride (PLN) in their co-formulated eye drops with the...

    Authors: Neamat T. Barakat, Amina M. El-Brashy and Mona E. Fathy
    Citation: BMC Chemistry 2024 18:27
  33. In the last few decades, green analytical chemistry (GAC) has become a smart magical solution for the qualification and quantification of many drugs. In the current study, a direct, sensitive, and green RP-HPL...

    Authors: Rana Ghonim, Manar M. Tolba, Fawzia Ibrahim and Mohamed I. El-Awady
    Citation: BMC Chemistry 2024 18:26
  34. Quantitative 1H-NMR became an increasingly important issue in pharmaceutical analytical chemistry. This study used NMR spectroscopy to assay the bronchodilator drug terbutaline sulfate and its pro-drug bambuterol...

    Authors: Asmaa El-Sayed, Mohamed A. Sabry, Heba Elmansi, Manal Eid and Shereen Shalan
    Citation: BMC Chemistry 2024 18:25
  35. Clusters, a novel hierarchical material structure that emerges from atoms or molecules, possess unique reactivity and catalytic properties, crucial in catalysis, biomedicine, and optoelectronics. Predicting cl...

    Authors: Wu Wei, Li Mengshan, Wu Yan and Guan Lixin
    Citation: BMC Chemistry 2024 18:24
  36. Heavy metals like Cadmium, Lead, and Chromium are the pollutants emitted into the environment through industrial development. In this work, a new diphenylamine coordinated cobalt complex (Co-DPA) has been synt...

    Authors: Mesfin Yimer, Shagufi Naz Ansari, Biniyam Abdu Berehe, Krishna Kanthi Gudimella, Gangaraju Gedda, Wubshet Mekonnen Girma, Nazim Hasan and Shadma Tasneem
    Citation: BMC Chemistry 2024 18:23

    The Correction to this article has been published in BMC Chemistry 2024 18:114

  37. The ligand, N′-(furan-2-ylmethylene)-2-hydroxybenzohydrazide (H2L), was synthesized characterized through various spectral studies which cleared out that the free ligand existed in keto form. The ligand upon reac...

    Authors: Nasser M. Hosny, Ghada Samir and Mohamed H. Abdel-Rhman
    Citation: BMC Chemistry 2024 18:22
  38. Aluminum corrosion inhibitors “{[CuI (CN)2(phen) CuII (CN)2(phen)]5H2O},(MOF1) and {[CuI(CN)2(phen)CuII(CN)2(phen)]5H2O}@TiO2 (MOF1@TiO2) were studied in one molar HCl solution”. The ML results for three differen...

    Authors: Abd El-Aziz S. Fouda, Safaa Eldin H. Etaiw, Dina M. Abd El-Aziz, Ahmed A. El-Hossiany and Usama A. Elbaz
    Citation: BMC Chemistry 2024 18:21
  39. High performance liquid chromatography is one of the techniques of choice for the separation and quantitative determination of drugs in mixture form. Ipriflavone, ascorbic acid, pyridoxine, vitamin D3, and lys...

    Authors: Sara Abdel Basset Galal, Eman Saad Elzanfaly, Emad Mohamed Hussien, Enas Abdel Hakim Amer and Hala Elsayed Zaazaa
    Citation: BMC Chemistry 2024 18:20
  40. Bromhexine (BR), guaiafenesin (GUF) and salbutamol (SAL) are formulated as Ventocough syrup® (with and without sugar), labeled to contain propyl paraben and sodium benzoate as inactive ingredients. They are us...

    Authors: Marco M. Z. Sharkawi, Mark T. Safwat, Eglal A. Abdelaleem and Nada S. Abdelwahab
    Citation: BMC Chemistry 2024 18:19
  41. For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green...

    Authors: Sayed M. Derayea, Khalid M. Badr El-Din, Ahmed S. Ahmed, Ahmed A. Khorshed and Mohamed Oraby
    Citation: BMC Chemistry 2024 18:18
  42. In this manuscript, the effectiveness of multivariate and univariate tools in conjunction with spectrophotometric techniques was evaluated for the concurrent analysis of ciprofloxacin (CI) and ornidazole (OR) ...

    Authors: Amir A. Sakur and Duaa Al Zakri
    Citation: BMC Chemistry 2024 18:17
  43. Nanocomposites based on copper, iron, and carbon materials are novel nanomaterials with both antibacterial and biocompatibility properties considerable to fight against multidrug-resistant bacteria.

    Authors: Mehran Alavi and Nasser Karimi
    Citation: BMC Chemistry 2024 18:16

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