García-Salas P, Gómez-Caravaca AM, Arráez-Román D, Segura-Carretero A, Guerra-Hernández E, García-Villanova B, Fernández-Gutiérrez A (2013) Influence of technological processes on phenolic compounds, organic acids, furanic derivatives, and antioxidant activity of whole-lemon powder. Food Chem 141:869–878
Article
CAS
Google Scholar
He D, Shan Y, Wu Y, Liu G, Chen B, Yao S (2011) Simultaneous determination of flavanones, hydroxycinnamic acids and alkaloids in citrus fruits by HPLC-DAD–ESI/MS. Food Chem 127:880–885
Article
CAS
Google Scholar
Kelebek H, Selli S (2011) Determination of volatile, phenolic, organic acid and sugar components in a Turkish cv. Dortyol (Citrus sinensis L. Osbeck) orange juice. J Sci Food Agric 91:1855–1862
Article
CAS
Google Scholar
Economos C, Clay WD (1999) Nutritional and health benefits of citrus fruits. Food Nutr Agric 24:11–18
Google Scholar
Committee NP (2010) Pharmacopoeia of People’s Republic of China, vol 2. China Medicinal Science and Technology Press, Beijing
Google Scholar
Food and Agricultural Organization of the United Nations. http://faostat3.fao.org/faostat-gateway/go/to/home/E
Flora Republicae Popularis Sinicae. http://frps.eflora.cn/frps/Citrus
Caristi C, Bellocco E, Panzera V, Toscano G, Vadala R, Leuzzi U (2003) Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars. J Agric Food Chem 51:3528–3534
Article
CAS
Google Scholar
Swingle WT (1967) The botany of Citrus and its wide relatives, vol 1. University of California Press, Berkeley
Google Scholar
Tanaka T (1977) Fundamental discussion of Citrus classification. Stud Citrol 14:1–6
Google Scholar
Barret H, Rhodes A (1976) A numerical taxonomic study of affinity relationships in cultivated Citrus and its close relatives. Syst Bot 1:105–136
Article
Google Scholar
Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M (1999) Quantitation of flavonoid constituents in citrus fruits. J Agric Food Chem 47:3565–3571
Article
CAS
Google Scholar
Liu Z, Liu Y, Wang C, Song Z, Zha Q, Lu C, Wang C, Lu A (2012) Discrimination of Zhishi from different species using rapid-resolution liquid chromatography-diode array detection/ultraviolet (RRLC-DAD/UV) coupled with multivariate statistical analysis. J Med Plants Res 6:866–875
CAS
Google Scholar
Liu Y, Liu Z, Wang C, Zha Q, Lu C, Song Z, Ning Z, Zhao S, Lu X, Lu A (2014) Study on essential oils from four species of Zhishi with gas chromatography–mass spectrometry. Chem Cent J 8:1–8
Article
CAS
Google Scholar
Aruoma OI, Landes B, Ramful-Baboolall D, Bourdon E, Neergheen-Bhujun V, Wagner KH, Bahorun T (2012) Functional benefits of citrus fruits in the management of diabetes. Prev Med 54:S12–S16
Article
Google Scholar
Peterson JJ, Beecher GR, Bhagwat SA, Dwyer JT, Gebhardt SE, Haytowitz DB, Holden JM (2006) Flavanones in grapefruit, lemons, and limes: a compilation and review of the data from the analytical literature. J Food Compost Anal 19:S74–S80
Article
CAS
Google Scholar
Chen J, Montanari AM, Widmer WW (1997) Two new polymethoxylated flavones, a class of compounds with potential anticancer activity, isolated from cold pressed dancy tangerine peel oil solids. J Agric Food Chem 45:364–368
Article
CAS
Google Scholar
Nielsen S, Breinholt V, Cornett C, Dragsted L (2000) Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. Food Chem Toxicol 38:739–746
Article
CAS
Google Scholar
Stohs SJ, Preuss HG, Shara M (2011) The safety of Citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine. Phytother Res PTR 25:1421–1428
Article
CAS
Google Scholar
Percy DW, Adcock JL, Conlan XA, Barnett NW, Gange ME, Noonan LK, Henderson LC, Francis PS (2010) Determination of Citrus aurantium protoalkaloids using HPLC with acidic potassium permanganate chemiluminescence detection. Talanta 80:2191–2195
Article
CAS
Google Scholar
Manners GD (2007) Citrus limonoids: analysis, bioactivity, and biomedical prospects. J Agric Food Chem 55:8285–8294
Article
CAS
Google Scholar
Breithaupt DE, Bamedi A (2001) Carotenoid esters in vegetables and fruits: a screening with emphasis on beta-cryptoxanthin esters. J Agric Food Chem 49:2064–2070
Article
CAS
Google Scholar
Gorinstein S, Cvikrova M, Machackova I, Haruenkit R, Park YS, Jung ST, Yamamoto K, Martinez Ayala AL, Katrich E, Trakhtenberg S (2004) Characterization of antioxidant compounds in Jaffa sweeties and white grapefruits. Food Chem 84:503–510
Article
CAS
Google Scholar
Shagirtha K, Pari L (2011) Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats. Ecotox environ Safe 74:2105–2111
Article
CAS
Google Scholar
Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST (2007) The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci 80:1821–1831
Article
CAS
Google Scholar
Koyuncu H, Berkarda B, Baykut F, Soybir G, Alatli C, Gül H, Altun M (1998) Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoter. Anticancer Res 19:3237–3241
Google Scholar
Aranganathan S, Selvam JP, Nalini N (2008) Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study. J Pharm Pharmacol 60:1385–1392
Article
CAS
Google Scholar
Aranganathan S, Nalini N (2013) Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1, 2-Dimethylhydrazine-induced Colon Cancer. Phytother Res 27:999–1005
Article
CAS
Google Scholar
Nie YC, Wu H, Li PB, Luo YL, Long K, Xie LM, Shen JG, Su WW (2012) Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. J Med Food 15:894–900
Article
CAS
Google Scholar
Arul D, Subramanian P (2013) Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Biochem Biophys Res Commun 434:203–209
Article
CAS
Google Scholar
Ekambaram G, Rajendran P, Magesh V, Sakthisekaran D (2008) Naringenin reduces tumor size and weight lost in N-methyl-N′-nitro-N-nitrosoguanidine–induced gastric carcinogenesis in rats. Nutr Res 28:106–112
Article
CAS
Google Scholar
Renugadevi J, Prabu SM (2010) Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol 62:171–181
Article
CAS
Google Scholar
Annadurai T, Muralidharan A, Joseph T, Hsu M, Thomas P, Geraldine P (2012) Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin–nicotinamide-induced experimental diabetic rats. J Physiol Biochem 68:307–318
Article
CAS
Google Scholar
Fallahi F, Roghani M, Moghadami S (2012) Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats. Indian J Pharmacol 44:382
Article
CAS
Google Scholar
Pan MH, Chen WJ, Lin-Shiau SY, Ho CT, Lin JK (2002) Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 23:1677–1684
Article
CAS
Google Scholar
Demonty I, Lin Y, Zebregs YE, Vermeer MA, van der Knaap HC, Jäkel M, Trautwein EA (2010) The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr 140:1615–1620
Article
CAS
Google Scholar
Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K (2009) Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against d-galactosamine-induced liver injury in rats. J Nutr Sci Vitaminol 56:60–67
Article
Google Scholar
Harasstani OA, Moin S, Tham CL, Liew CY, Ismail N, Rajajendram R, Harith HH, Zakaria ZA, Mohamad AS, Sulaiman MR (2010) Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells. Inflamm Res 59:711–721
Article
CAS
Google Scholar
Lee YC, Cheng TH, Lee JS, Chen JH, Liao YC, Fong Y, Wu CH, Shih YW (2011) Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. Mol Cell Biochem 347:103–115
Article
CAS
Google Scholar
Mulvihill EE, Assini JM, Sutherland BG, DiMattia AS, Khami M, Koppes JB, Sawyez CG, Whitman SC, Huff MW (2010) Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat–fed low-density lipoprotein receptor–null mice. Arterioscl Throm Vas 30:742–748
Article
CAS
Google Scholar
Seki T, Kamiya T, Furukawa K, Azumi M, Ishizuka S, Takayama S, Nagase S, Arai H, Yamakuni T, Yaegashi N (2013) Nobiletin-rich Citrus reticulata peels, a kampo medicine for Alzheimer’s disease: a case series. Geriatr Gerontol Int 13:236–238
Article
Google Scholar
Siahpoosh A, Javedani F (2012) Antioxidative capacity of Iranian Citrus deliciosa peels. Free Radic Antioxid 2:62–67
Article
CAS
Google Scholar
Jagdeep S, Shailja S, Arunachalam M (2014) In-vitro evaluation of bioactive compounds, anti-oxidant, lipid peroxidation and lipoxygenase inhibitory potential of Citrus karna L. peel extract. J Food Sci Technol 51:67–74
Article
CAS
Google Scholar
Padilla-Camberos E, Lazcano-Díaz E, Flores-Fernandez JM, Owolabi MS, Allen K, Villanueva-Rodríguez S (2014) Evaluation of the inhibition of carbohydrate hydrolyzing enzymes, the antioxidant activity, and the polyphenolic content of Citrus limetta peel extract. Sci World J 2014:1–4
Article
Google Scholar
Impellizzeri D, Bruschetta G, Di Paola R, Ahmad A, Campolo M, Cuzzocrea S, Esposito E, Navarra M (2014) The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease. Clin Nutr 27 (pii: S0261-5614(14)00293-3)
Hirata T, Fujii M, Akita K, Yanaka N, Ogawa K, Kuroyanagi M, Hongo D (2009) Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer. Bioorgan Med Chem 17:25–28
Article
CAS
Google Scholar
Osawa T (1994) Novel natural antioxidants for utilization in food and biological systems. In: Uritani I, Garcia VV, Mendoza EM (eds) Postharvest biochemistry of plant food-materials in the tropics. Japan Scientific Societies Press, Japan, pp 241–251
Google Scholar
Cotelle N (2001) Role of flavonoids in oxidative stress. Curr Top Med Chem 1:569–590
Article
CAS
Google Scholar
Mari M, Colell A, Morales A, von Montfort C, Garcia-Ruiz C, Fernandez-Checa JC (2010) Redox control of liver function in health and disease. Antioxid Redox Sign 12:1295–1331
Article
CAS
Google Scholar
Barreca D, Bellocco E, Caristi C, Leuzzi U, Gattuso G (2010) Flavonoid composition and antioxidant activity of juices from chinotto (Citrus × myrtifolia Raf.) fruits at different ripening stages. J Argic Food Chem 58:3031–3036
Article
CAS
Google Scholar
Kim HG, Kim GS, Park S, Lee JH, Seo ON, Lee SJ, Kim JH, Shim JH, Abd El-Aty A, Jin JS (2012) Flavonoid profiling in three citrus varieties native to the Republic of Korea using liquid chromatography coupled with tandem mass spectrometry: contribution to overall antioxidant activity. Biomed Chromatogr 26:464–470
Article
CAS
Google Scholar
Sun Y, Qiao L, Shen Y, Jiang P, Chen J, Ye X (2013) Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. J Food Sci 78:C37–C42
Article
CAS
Google Scholar
Aranganathan S, Nalini N (2009) Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1, 2-dimethylhydrazine induced colon carcinogenesis. Food Chem Toxicol 47:2594–2600
Article
CAS
Google Scholar
Kilci A, Gocmen D (2014) Phenolic acid composition, antioxidant activity and phenolic content of tarhana supplemented with oat flour. Food Chem 151:547–553
Article
CAS
Google Scholar
Ogiwara T, Satoh K, Negoro T, Okayasu H, Sakagami H, Fujisawa S (2003) Inhibition of NO production by activated macrophages by phenolcarboxylic acid monomers and polymers with radical scavenging activity. Anticancer Res 23:1317–1323
CAS
Google Scholar
Abdel-Salam OM, Youness ER, Mohammed NA, Morsy SM, Omara EA, Sleem AA (2014) Citric acid effects on brain and liver oxidative stress in lipopolysaccharide-treated mice. J Med Food 17:588–598
Article
CAS
Google Scholar
Korani MS, Farbood Y, Sarkaki A, Fathi Moghaddam H, Taghi Mansouri M (2014) Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats. Eur J Pharmacol 733:62–67
Article
CAS
Google Scholar
Karamac M, Kosinska A, Pegg RB (2005) Comparison of radical-scavenging activities for selected phenolic acids. Polish J Food Nutri Sci 14:165–170
CAS
Google Scholar
Jabri Karoui I, Marzouk B (2013) Characterization of bioactive compounds in Tunisian bitter orange (Citrus aurantium L.) peel and juice and determination of their antioxidant activities. Biomed Res Int 2013: 345415
Singh P, Shukla R, Prakash B, Kumar A, Singh S, Mishra PK, Dubey NK (2010) Chemical profile, antifungal, antiaflatoxigenic and antioxidant activity of Citrus maxima Burm. and Citrus sinensis (L.) Osbeck essential oils and their cyclic monoterpene, DL-limonene. Food Chem Toxicol 48:1734–1740
Article
CAS
Google Scholar
Choi HS, Song HS, Ukeda H, Sawamura M (2000) Radical-scavenging activities of citrus essential oils and their components: detection using 1, 1-diphenyl-2-picrylhydrazyl. J Agric Food Chem 48:4156–4161
Article
CAS
Google Scholar
Tundis R, Loizzo MR, Bonesi M, Menichini F, Mastellone V, Colica C, Menichini F (2012) Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils. J Food Sci 77:H40–H46
Article
CAS
Google Scholar
Masamoto Y, Ando H, Murata Y, Shimoishi Y, Tada M, Takahata K (2003) Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L. Biosci Biotech Biochem 67:631–634
Article
CAS
Google Scholar
Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C (2001) Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276:32008–32015
Article
CAS
Google Scholar
Norihiro Y, Takahiro F, Hitoshi M, Takeshi O, Kunio S, Ron H (2014) Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE2 production in HaCaT cells through PPAR-c activation. Exp Dermatol 23:18–22
Google Scholar
Bodet C, La V, Epifano F, Grenier D (2008) Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models. J Periodontal Res 43:400–407
Article
CAS
Google Scholar
Yuasa K, Tada K, Harita G, Fujimoto T, Tsukayama M, Tsuji A (2011) Sudachitin, a polymethoxyflavone from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells. Biosci Biotech Biochem 76:598–600
Article
CAS
Google Scholar
Wang AY, Zhou MY, Lin WC (2011) Antioxidative and anti-inflammatory properties of Citrus sulcata extracts. Food Chem 124:958–963
Article
CAS
Google Scholar
Yoshigai E, Machida T, Okuyama T, Mori M, Murase H, Yamanishi R, Okumura T, Ikeya Y, Nishino H, Nishizawa M (2013) Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1beta-treated hepatocytes. Biochem Biophys Res Commun 439:54–59
Article
CAS
Google Scholar
Kummer R, Fachini-Queiroz FC, Estevão-Silva CF, Grespan R, Silva EL, Bersani-Amado CA, Cuman RKN (2013) Evaluation of anti-inflammatory activity of Citrus latifolia Tanaka essential oil and limonene in experimental mouse models. Evid Based Complement Altern 2013:859083
Google Scholar
Borgatti M, Mancini I, Bianchi N, Guerrini A, Lampronti I, Rossi D, Sacchetti G, Gambari R (2011) Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC Biochem 12:15
Article
CAS
Google Scholar
Lin S, Hirai S, Goto T, Sakamoto T, Takahashi N, Yano M, Sasaki T, Yu R, Kawada T (2013) Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation. Mol Nutr Food Res 57:1135–1144
Article
CAS
Google Scholar
Huang GJ, Deng JS, Liao JC, Hou WC, Wang SY, Sung PJ, Kuo YH (2012) Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis. J Agric Food Chem 60:1673–1681
Article
CAS
Google Scholar
Sood S, Muthuraman A, Gill NS, Bali M, Sharma PD (2010) Role of 7, 8-dimethoxycoumarin in anti-secretary and anti-inflammatory action on pyloric ligation-induced gastritis in rats. J Asian Nat Prod Res 12:593–599
Article
CAS
Google Scholar
Do-Hoon L, Kwang-Il P, Hyeon-Soo P, Sang-Rim K, Arulkumar N, Jin-A K, Eun-Hee K, Won-Sup L, Young-Sool H, Hyon-Jong C, Su-Jin A, Gon-Sup K (2012) Flavonoids isolated from korea Citrus aurantium L. induce G2/M phase arrest and apoptosis in human gastric cancer AGS cells. Evid Based Complement Alternat 2012:1–11
Takuji T, Takahiro T, Mayu T, Toshiya K (2012) Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin. J Biomed Biotechnol 2012:1–10
Google Scholar
Hang X, Chung SY, Shiming L, Huanyu J, Chi-Tang H, Trusha P (2009) Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mol Nutr Food Res 53:398–406
Article
CAS
Google Scholar
Jin H, Lee WS, Yun JW, Jung JH, Yi SM, Kim HJ, Choi YH, Kim G, Jung JM, Ryu CH, Shin SC, Hong SC (2013) Flavonoids from Citrus unshiu Marc. inhibit cancer cell adhesion to endothelial cells by selective inhibition of VCAM-1. Oncol Rep 30:2336–2342
CAS
Google Scholar
Ching-Shu L, Shiming L, ChengBin L, Yutaka M, Michiko S, Chi-Tang H, Min-Hsiung P (2013) Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids. Mol Nutr Food Res 57:551–555
Article
CAS
Google Scholar
Duraikannu A, Perumal S (2013) Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Biochem Biophys Res Commun 434:203–209
Article
CAS
Google Scholar
Asghar G, Maryam N, Mahmood JT, Hamid Z (2012) The citrus flavonoid hesperidin induces p53 and inhibits NF-jB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARc-dependent mechanism. Eur J Nutr 51:39–46
Google Scholar
Chang L, Jia S, Fu Y, Zhou T, Cao J, He Q, Yang B, Li X, Sun C, Su D, Zhu H, Chen K (2015) Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells. Chin Med 10:14–23
Article
CAS
Google Scholar
Johnson JL, de Mejia EG (2013) Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3beta/NF-kappaB signaling cascade. Mol Nutr Food Res 57:2112–2127
Article
CAS
Google Scholar
Zhu X, Luo F, Zheng Y, Zhang J, Huang J, Sun C, Li X, Chen K (2013) Characterization, purification of poncirin from edible citrus ougan (Citrus reticulate cv. suavissima) and its growth inhibitory effect on human gastric cancer cells SGC-7901. Int J Mol Sci 14:8684–8697
Article
CAS
Google Scholar
Steele VE, Moon RC, Lubet RA, Grubbs CJ, Reddy BS, Wargovich M (1994) Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: methods and results from the NCI Chemoprevention Drug Development Program. J Cell Biochem 56:32–54
Article
Google Scholar
Wesołowska O, Wiśniewski J, Środa-Pomianek K, Bielawska-Pohl A, Paprocka M, Duś D, Duarte NL, Ferreira M-JU, Michalak K (2012) Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants. J Nat Prod 75:1896–1902
Article
CAS
Google Scholar
Qiu P, Dong P, Guan H, Li S, Ho CT, Pan MH, McClements DJ, Xiao H (2010) Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mol Nutr Food Res 54:S244–S252
Article
CAS
Google Scholar
Kim J, Jayaprakasha GK, Vikram A, Patil BS (2012) Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro. Toxicol In Vitro 26:1216–1223
Article
CAS
Google Scholar
Kim J, Jayaprakasha GK, Patil BS (2013) Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells. Food Funct 4:258–265
Article
CAS
Google Scholar
Murthy KNC, Jayaprakasha G, Patil BS (2013) Citrus limonoids and curcumin additively inhibit human colon cancer cells. Food Funct 4:803–810
Article
CAS
Google Scholar
Prince M, Li Y, Childers A, Itoh K, Yamamoto M, Kleiner HE (2009) Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. Toxicol Lett 185:180–186
Article
CAS
Google Scholar
Patil JR, Jayaprakasha GK, Kim J, Murthy KN, Chetti MB, Nam SY, Patil BS (2013) 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med 79:219–226
Article
CAS
Google Scholar
Narisawa T, Fukaura Y, Oshima S, Inakuma T, Yano M, Nishino H (1999) Chemoprevention by the oxygenated carotenoid beta-cryptoxanthin of N-methylnitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res: Gann 90:1061–1065
Article
CAS
Google Scholar
Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR (2007) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 85:895–909
CAS
Google Scholar
Herwandhani P, Standie N, Yonika Arum L, Nindi W, Adam H (2013) Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model. Asian Pacific J Trop Biomed 3:371–375
Article
CAS
Google Scholar
Lin Y, Vermeer MA, Bos W, van Buren L, Schuurbiers E, Miret-Catalan S, Trautwein EA (2011) Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. J Agric Food Chem 59:4496–4503
Article
CAS
Google Scholar
Yen JH, Weng CY, Li S, Lo YH, Pan MH, Fu SH, Ho CT, Wu MJ (2011) Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells. Mol Nutr Food Res 55:733–748
Article
CAS
Google Scholar
Shen W, Xu Y, Lu YH (2012) Inhibitory effects of citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells. J Agric Food Chem 60:9609–9619
Article
CAS
Google Scholar
Akiyama S, Katsumata SI, Suzuki K, Ishimi Y, Wu J, Uehara M (2010) Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats. J Clin Biochem Nutr 46:87
Article
CAS
Google Scholar
Liu L, Shan S, Zhang K, Ning ZQ, Lu XP, Cheng YY (2008) Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin. Phytother Res 22:1400–1403
Article
CAS
Google Scholar
Reshef N, Hayari Y, Goren C, Boaz M, Madar Z, Knobler H (2005) Antihypertensive Effect of Sweetie Fruit in Patients With Stage I Hypertension*. Am J Hypertens 18:1360–1363
Article
CAS
Google Scholar
Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C (2011) Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocr Metab 96:E782–E792
Article
CAS
Google Scholar
Ming W, Hongwu Z, Chao Z, Hongmei J, Zhuo M, Zhongmei Z (2015) Identification of the chemical constituents in aqueous extract of Zhi-Qiao and evaluation of its antidepressant effect. Molecules 20:6925–6940
Article
CAS
Google Scholar
Hwang SL, Yen GC (2008) Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. J Agric Food Chem 56:859–864
Article
CAS
Google Scholar
Hwang SL, Yen GC (2009) Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide. J Agric Food Chem 57:2576–2582
Article
CAS
Google Scholar
Okuyama S, Shimada N, Kaji M, Morita M, Miyoshi K, Minami S, Amakura Y, Yoshimura M, Yoshida T, Watanabe S, Nakajima M, Furukawa Y (2012) Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice. Neurosci Lett 528:190–195
Article
CAS
Google Scholar
Epifano F, Molinaro G, Genovese S, Ngomba RT, Nicoletti F, Curini M (2008) Neuroprotective effect of prenyloxycoumarins from edible vegetables. Neurosci Lett 443:57–60
Article
CAS
Google Scholar
Okuyama S, Minami S, Shimada N, Makihata N, Nakajima M, Furukawa Y (2013) Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice. Eur J Pharmacol 699:118–123
Article
CAS
Google Scholar
Mahmoud MF, Hamdan DI, Wink M, El-Shazly AM (2013) Hepatoprotective effect of limonin, a natural limonoid from the seed of Citrus aurantium var. bigaradia, on d-galactosamine-induced liver injury in rats. N-S Arch Pharmacol 387:251–261
Article
CAS
Google Scholar
Espina L, Somolinos M, Loran S, Conchello P, García D, Pagán R (2011) Chemical composition of commercial citrus fruit essential oils and evaluation of their antimicrobial activity acting alone or in combined processes. Food Control 22:896–902
Article
CAS
Google Scholar
Vikram A, Jesudhasan PR, Jayaprakasha G, Pillai SD, Jayaraman A, Patil BS (2011) Citrus flavonoid represses Salmonella pathogenicity island 1 and motility in S. Typhimurium LT2. Int J Food Microbiol 145:28–36
Article
CAS
Google Scholar
Vikram A, Jayaprakasha G, Jesudhasan P, Pillai S, Patil B (2010) Suppression of bacterial cell–cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J Appl Microbiol 109:515–527
CAS
Google Scholar
Murata K, Takano S, Masuda M, Iinuma M, Matsuda H (2013) Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits. J Nat Med 67:643–646
Article
CAS
Google Scholar
Itoh K, Hirata N, Masuda M, Naruto S, Murata K, Wakabayashi K, Matsuda H (2009) Inhibitory effects of Citrus hassaku extract and its flavanone glycosides on melanogenesis. Biol Pharm Bull 32:410–415
Article
CAS
Google Scholar
Eri O, Jun I, Tsutomu H, Makoto S, Ryuichiro S (2011) Anti-obesity and anti-hyperglycemic nomilin in mice fed a high-fat diet. Biochem Bioph Res Co 410:677–681
Article
CAS
Google Scholar
Seong-Il K, Hye-Sun S, Hyo-Min K, Youn-Suk H, Seon-A Y, Seung-Woo K, Jeong-Hwan K, Moo-Han K, Hee-Chul K, Se-Jae K (2012) Immature Citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice. Biol Pharm Bull 35:223–230
Article
Google Scholar
Xian-Mei Z, Gao-Yan W, Yang Z, Yu-Mei L, Jian-Xin L (2013) Inhibitory effects of alkaline extract of Citrus reticulata on pulmonary fibrosis. J Ethnopharmacol 146:372–378
Article
Google Scholar
Sung Hee K, Haeng Jeon H, Hye Jeong Y, Hyun Jin K, Min Jung K, Jae Ho P, Mi Jeong S, Myung Sunny K, Dae Young K, Jin-Taek H (2013) Citrus junos tanaka peel extract exerts antidiabetic effects via AMPK and PPAR- both in vitro and in vivo in mice fed a high-fat diet. Evid Based Complement Alternat 2013: 1–8
Madhyastha H, Yamaguchi M, Sameshima H, Ikenoue T, Maruyama M (2013) Revealing the mechanism of in vitro wound healing properties of Citrus tamurana extract. Biomed Res Int 2013:1–8
Google Scholar
Aya I, Noriyuki S, Takashi T, Toshiki O, Hisayoshi N (2013) Antianxiety-like effects of Chimpi (dried Citrus peels) in the elevated open-platform test. Molecules 18:10014–10023
Article
CAS
Google Scholar
Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I (2010) Citrus consumption and cancer incidence: the Ohsaki cohort study. Int J Cancer 127:1913–1922
Article
CAS
Google Scholar
Nurk E, Refsum H, Drevon CA, Tell GS, Nygaard HA, Engedal K, Smith AD (2010) Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study. Br J Nutr 104:1190–1201
Article
CAS
Google Scholar
Sacco SM, Horcajada MN, Offord E (2013) Phytonutrients for bone health during ageing. Br J Clin Pharmacol 75:697–707
Article
CAS
Google Scholar
Deyhim F, Lopez E, Gonzalez J, Garcia M, Patil BS (2006) Citrus juice modulates antioxidant enzymes and lipid profiles in orchidectomized rats. J Med Food 9:422–426
Article
Google Scholar
Kim SS, Baik JS, Oh TH, Yoon WJ, Lee NH, Hyun CG (2008) Biological activities of Korean Citrus obovoides and Citrus natsudaidai essential oils against acne-inducing bacteria. Biosci Biotechnol Biochem 72:2507–2513
Article
CAS
Google Scholar
Wilkins MR, Widmer WW, Grohmann K, Cameron RG (2007) Hydrolysis of grapefruit peel waste with cellulase and pectinase enzymes. Bioresour Technol 98:1596–1601
Article
CAS
Google Scholar
Marin FR, Soler-Rivas C, Benavente-Garcia O, Castillo J, Perez-Alvarez JA (2007) By-products from different citrus processes as a source of customized functional fibres. Food Chem 100:736–741
Article
CAS
Google Scholar
Curl AL, Bailey GF (1961) The carotenoids of Navel oranges. J Food Sci 26:442–447
Article
CAS
Google Scholar
Minamisawa M, Yoshida S, Uzawa A (2014) The functional evaluation of waste yuzu (Citrus junos) seeds. Food Funct 5:330–336
Article
CAS
Google Scholar