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  1. Preserving the environment, reducing the amount of waste resulting from chemical trials, and reducing the amount of energy consumed have currently become a pivotal global trend. An analytical quality by design...

    Authors: Hend M. Nagieb, Nada S. Abdelwahab, Maha M. Abdelrahman, Hala E. Zaazaa and Nermine S. Ghoniem
    Citation: BMC Chemistry 2024 18:15
  2. Undecaprenyl Pyrophosphate Synthase (UPPS) is a vital target enzyme in the early stages of bacterial cell wall biosynthesis. UPPS inhibitors have antibacterial activity against resistant strains such as MRSA a...

    Authors: Basma M. Qandeel, Samar Mowafy, Khaled Abouzid and Nahla A. Farag
    Citation: BMC Chemistry 2024 18:14
  3. This study describes methodologies for extracting and isolating bergenin, a C-glucoside of 4-O-methylgallic acid found in some plants and it presents various in vitro and in vivo biological activities. Bergenin w...

    Authors: Oscar Caetano Silva-Neto, Caio Silva Assis Felix, Leonardo de Oliveira Aguiar, Mauricio Brandão dos Santos, Silvio Cunha and Jorge Mauricio David
    Citation: BMC Chemistry 2024 18:13
  4. Zinc chromium oxide (Cr/ZnO, 5wt.%) was prepared by a facile chemical co-precipitation route. The structure, composition, and chemical bonding were analyzed using X-ray diffraction (XRD), Energy dispersive X-r...

    Authors: Wageha A. Mostafa, Soad A. Elshanawany, Khadejah D. Otaif, Mona khalifa and Elsayed Elgazzar
    Citation: BMC Chemistry 2024 18:11
  5. A green, efficient, sensitive and accurate detection method by HPLC–DAD and LC–MS/MS was developed and validated for the quantification of morphine, hydromorphone, oxycodone, ketamine tramadol, dezocine, ropiv...

    Authors: Manman Yao, Baoxia Fang, Jinguo Yang, Sicen Wang and Fuchao Chen
    Citation: BMC Chemistry 2024 18:10
  6. Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles were successfully synthesiz...

    Authors: Halefom Gebreselasse Berhe, Yihenew Simegniew Birhan, Botros Youssef Beshay, Huda Jawad Habib, Ariaya Hymete and Adnan Ahmed Bekhit
    Citation: BMC Chemistry 2024 18:9
  7. The current study effectively designed novel cross-linked tosyl-carrageenan/alginate (Ts-Car/Alg) beads to remove Pb2+ ions from their aqueous solutions. To confirm the structure of the produced matrix, character...

    Authors: Mohamed Awed, Riham R. Mohamed, Kholod H. Kamal, Magdy W. Sabaa and Korany A. Ali
    Citation: BMC Chemistry 2024 18:8
  8. This study marks a pioneering effort in utilizing Vachellia tortilis subsp. raddiana (Savi) Kyal. & Boatwr., (commonly known as acacia raddiana) leaves as both a reducing and stabilizing agent in the green “eco-f...

    Authors: Nesma H. Ibrahim, Gharib M. Taha, Noura Sh. A. Hagaggi and Marwa A. Moghazy
    Citation: BMC Chemistry 2024 18:7
  9. Two series of novel imidazo[1,2-a]pyridine-2-carbohydrazide derivatives have been designed, synthesized, and evaluated for cytotoxic activity. Target compounds were designed in two series: aryl hydrazone deriv...

    Authors: Maryam Firouzi, Zahra Haghighijoo, Masoomeh Eskandari, Maryam Mohabbati, Ramin Miri, Mohammad Hasan Jamei, Alireza Poustforoosh, Somayeh Nazari, Omidreza Firuzi, Mehdi Khoshneviszadeh and Najmeh Edraki
    Citation: BMC Chemistry 2024 18:6
  10. In this study, the Fe3O4/rGO/Ag magnetic nanocomposite was synthesized and employed as an adsorbent for the removal of tetracycline (TC), crystal violet (CV), and methylene blue (MB) from water samples. The influ...

    Authors: Chou-Yi Hsu, Eyhab Ali, Haider Falih Shamikh Al-Saedi, Amjed Qasim Mohammed, Nadia Khalid Mustafa, Maysm Barzan Talib, Usama Kadem Radi, Montather F. Ramadan, Ahmed Ali Ami, Saeb Jasim Al-Shuwaili, Ahmed Alawadi, Ali Alsalamy and Leila Baharinikoo
    Citation: BMC Chemistry 2024 18:5
  11. The development of biobased polymeric materials for wastewater purification has become a demand due to the growing need for water free of hazardous metal ions for safe purposes. The organic components of the O...

    Authors: Isra Ishraydeh, Othman Hamed, Abdalhadi Deghles, Shehdeh Jodeh, Khalil Azzaoui, Abdelfattah Hasan, Mohyeddin Assali, Ataa Jaseer, Waseem Mansour, Gül Gülenay Hacıosmanoğlu, Zehra Semra Can and Manuel Algarra
    Citation: BMC Chemistry 2024 18:4
  12. The design and synthesis of novel cytotoxic agents is still an interesting topic for medicinal chemistry researchers due to the unwanted side effects of anticancer drugs. In this study, a novel series of uraci...

    Authors: Leila Emami, Fateme Zare, Soghra Khabnadideh, Zahra Rezaei, Zahra Sabahi, Saman Zare Gheshlaghi, Marzieh Behrouz, Mina Emami, Zahra Ghobadi, Sedighe Madadelahi Ardekani, Fatemeh Barzegar, Ali Ebrahimi and Razieh Sabet
    Citation: BMC Chemistry 2024 18:3
  13. In the current study we suggest a novel approach to curb non-alcoholic steatohepatitis (NASH) progression, and we suggest privileged scaffolds for the design of novel compounds for this aim. NASH is an advance...

    Authors: Yara A. Zaky, Mai W. Rashad, Marwa A. Zaater and Ahmed M. El Kerdawy
    Citation: BMC Chemistry 2024 18:2
  14. Several novel approaches to target Bcl-2 proteins and apoptotic pathways have been identified in recent years for the treatment of different types of cancer including colorectal cancer. However, no effective t...

    Authors: Sama W. Helmy, Mai I. Shahin, Nermin Samir, Deena S. Lasheen and Dalal A. Abou El Ella
    Citation: BMC Chemistry 2024 18:1
  15. The discovery of new lead skeleton against melanoma are urgently needed due to its highly malignant and mortality. Herein, a new molecular entity (EU-5) derived from eudistomin U was synthesized with total yie...

    Authors: Jixiang Gao, Jinyi Liu, Tao Yu, Chenggong Xu, Hao Sun, Chunbo Lu, Wenjia Dan and Jiangkun Dai
    Citation: BMC Chemistry 2023 17:184
  16. Carbapenem-resistant Enterobacterales (CRE) has emerged as a worldwide spread nosocomial superbug exhibiting antimicrobial resistance (AMR) to all current antibiotics, leaving limited options for treating its ...

    Authors: Wenbin Jin, Chen Xu, Ning Dong, Kaichao Chen, Die Zhang, Jinhua Ning, Yunbing Li, Guangfen Zhang, Jin Ke, Anguo Hou, Linyun Chen, Sheng Chen and Kin-Fai Chan
    Citation: BMC Chemistry 2023 17:183
  17. Fraxinus hubeiensis is a plant endemic to China and widely used as folk medicine to treat various diseases. However, its chemical constituents have never been reported sufficiently. Thus, the primary objective of...

    Authors: Xin-Yi Liu, Hong-Xia Tang, Wen-Bing Sheng, Qu-Jing Luo, Lin-Xi Mao, Yu-Pei Yang, Xiao-Zhou Guo, Qing-Lai Wu, Yu-Qing Jian, Wei Wang and Xu-Dong Zhou
    Citation: BMC Chemistry 2023 17:182
  18. Three green and facile spectrophotometric methods were developed for the assay of Petro® components; drotaverine HCl (DRT), caffeine (CAFF), and paracetamol (PAR). The three methods depend on measuring the absorb...

    Authors: Rana Ghonim, Manar M. Tolba, Fawzia Ibrahim and Mohamed I. El-Awady
    Citation: BMC Chemistry 2023 17:181
  19. Nanoparticle-based composites have the potential to meet requirements for radiosensitization in both therapeutic and diagnostic applications. The radiosensitizing properties of nanoparticles could be reliant o...

    Authors: Elham Mansouri, Asghar Mesbahi, Hamed Hamishehkar, Soheila Montazersaheb, Vahid Hosseini and Saeed Rajabpour
    Citation: BMC Chemistry 2023 17:180
  20. As a GABA-β receptor agonist, the central muscle relaxant Baclofen (BAC) has a potential of abuse. Unfortunately, the sense of wellbeing and pleasure is obtained at very high BAC doses. This is associated with...

    Authors: Mariam O. Abd el-Aziz, Ahmed H. Nadim, Hany H. Monir, M. Nebsen and Sameh E. Younis
    Citation: BMC Chemistry 2023 17:179
  21. The use of sustainable solvents has increased significantly in recent years due to advancements in green analytical methods. The number of impurities in the drug substance determines how safe the finished prod...

    Authors: Heidi R. Abd El-Hadi, Maya S. Eissa, Hala E. Zaazaa and Basma M. Eltanany
    Citation: BMC Chemistry 2023 17:177
  22. The multivariate models that are used for spectral data analysis have many beneficial applications, and one of the important applications is the analysis of drugs and their impurities. Three Chemometrically-as...

    Authors: Mona A. Abdel Rahman, Mohamed R. Elghobashy, Hala E. Zaazaa and Sally S. El-Mosallamy
    Citation: BMC Chemistry 2023 17:176
  23. The psychoanaleptic medication atomoxetine (ATX) is prescribed to cure attention-deficit hyperactivity syndrome. ATX works by selective prevention of norepinephrine reuptake. It acts by raising the brain’s nat...

    Authors: Ahmed A. Abu-hassan
    Citation: BMC Chemistry 2023 17:175
  24. In the present study, we explored the potential of coumarin-based compounds, known for their potent anticancer properties, by designing and synthesizing a novel category of 8-methoxycoumarin-3-carboxamides. Ou...

    Authors: Ahmad Alzamami, Eman M. Radwan, Eman Abo-Elabass, Mohammed El Behery, Hussah Abdullah Alshwyeh, Ebtesam Al-Olayan, Abdulmalik S. Altamimi, Nashwah G. M. Attallah, Najla Altwaijry, Mariusz Jaremko and Essa M. Saied
    Citation: BMC Chemistry 2023 17:174
  25. Two accurate, sensitive, and selective methods for simultaneous determination of miconazole nitrate (MIC), nystatin (NYS), and metronidazole (MET) in pure state or drug product were established and verified. F...

    Authors: Maha M. Abdelrahman, Ibrahim A. Naguib, Hala E. Zaazaa and Hend M. Nagieb
    Citation: BMC Chemistry 2023 17:173
  26. Selenocompounds protect against damage to healthy cells and induce the death of tumor cells by apoptosis; for this reason, they are attractive compounds for cancer research. In the present study, two series of...

    Authors: Wenxin Xu, Yali Du, Beibin Pan, Qiying Wang, Haoran Zheng, Ruonan Zhang, Jiaxin Lou, Guanghui Zhu, Jie Zhou and Jian Sun
    Citation: BMC Chemistry 2023 17:172
  27. Mesalazine (5-ASA) is a medication utilized to treat inflammatory bowel diseases involving ulcerative colitis and Crohn’s disease. Mesalazine has fewer side effects but the low solubility and bioavailability o...

    Authors: Elina Armani, Parisa Jafari, Salar Hemmati, Elaheh Rahimpour, Mohammad Barzegar-Jalali and Abolghasem Jouyban
    Citation: BMC Chemistry 2023 17:171
  28. Environmental appearance of antimicrobials due to frequent use of personal care products as recommended by WHO can cause serious flare-up of antimicrobial resistance. In this work, three eco-friendly microfabr...

    Authors: Nardine Safwat, Amr M. Mahmoud, Maha F. Abdel-Ghany and Miriam F. Ayad
    Citation: BMC Chemistry 2023 17:170
  29. The improvement of the solubility of sulfasalazine in physiological media was the major aim of this study. Accordingly, BNNT inspected as a notable candidate for the carriage of this drug in aqueous media. For...

    Authors: Sepideh Ketabi, Saba Shalmashi and Sara Hallajian
    Citation: BMC Chemistry 2023 17:169
  30. The study reports the development of a high-performance liquid chromatography/diode array detection method to measure the levels of nirmatrelvir and ritonavir in human plasma. These two antiviral medications a...

    Authors: Inas A. Abdallah, Sherin F. Hammad, Alaa Bedair and Fotouh R. Mansour
    Citation: BMC Chemistry 2023 17:166
  31. Ametryn (AME) is a triazine herbicide which is mainly used to kill unwanted herbs in crops. Despite its importance in agriculture, the usage of AME also poses a risk to humans and the ecosystem due to its toxi...

    Authors: Rachel Marcella Roland, Showkat Ahmad Bhawani and Mohamad Nasir Mohamad Ibrahim
    Citation: BMC Chemistry 2023 17:165
  32. Three-levels Box-Behnken design was used in the experimental design approach for the optimization of chromatographic parameters to achieve the optimum resolution and sharp peak shape within a reasonable run ti...

    Authors: Eman A. Mostafa, Mohamed K. El‐Ashrey and Sally Tarek Mahmoud
    Citation: BMC Chemistry 2023 17:164
  33. Two simple and rapid chromatographic methods were developed and validated for the analysis of levamisole and triclabendazole simultaneously in pure and pharmaceutical products. The first method is thin-layer c...

    Authors: Khalid A. M. Attia, Ebrahim A. El-Desouky, Amr M. Abdelfatah and Nahla A. Abdelshafi
    Citation: BMC Chemistry 2023 17:163
  34. The physical and chemical structure of activated carbon (AC) varies with the carbonization temperature, activation process and time. The texture and toughness of the starting raw material also determine the mo...

    Authors: Ibrahim Karume, Simon Bbumba, Simon Tewolde, Is’harq Z. T. Mukasa and Muhammad Ntale
    Citation: BMC Chemistry 2023 17:162
  35. Melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream prometastatic gene r...

    Authors: Nivedita Singh, Faiz M Khan, Lakshmi Bala, Julio Vera, Olaf Wolkenhauer, Brigitte Pützer, Stella Logotheti and Shailendra K. Gupta
    Citation: BMC Chemistry 2023 17:161
  36. In this study, an environmentally friendly, solvent- and catalyst-free synthesis of 2-anilino nicotinic acids derivatives is reported. This operationally simple and green procedure was applied to a selection o...

    Authors: Mahsa Yarhorhosseini, Shahrzad Javanshir, Ahmad Shahir Sadr, Milad Noori, Navid Dastyafteh, Maryam Esmkhani, Aida Iraji and Mohammad Mahdavi
    Citation: BMC Chemistry 2023 17:160
  37. In this work, we focused on the 3rd goal of the sustainable development plan: achieving good health and supporting well-being. Two redox-active hydrazo ligands namely, phenylcarbonohydrazonoyldicyanide (PCHD) and...

    Authors: Eman Hassan Elsayed, Dhuha Al-Wahaib, Ali El-Dissouky Ali, Beshir A. Abd-El-Nabey and Hemmat A. Elbadawy
    Citation: BMC Chemistry 2023 17:159
  38. Water contamination has become a global challenge to human survival. Non-biodegradable heavy metal cations and steroid hormones could accumulate in the human body and could result in serious health problems. I...

    Authors: Sefiu Olaitan Amusat, Temesgen Girma Kebede, Edward Ndumiso Nxumalo, Simiso Dube and Mathew Muzi Nindi
    Citation: BMC Chemistry 2023 17:158
  39. Lebanese cuisine is renowned for its distinctive flavours and vibrant aromas. In Lebanese cuisine, spices are not just used for their flavour; they are also valued for their medicinal properties. This study co...

    Authors: Youssef El Rayess, Lea Nehme, Chantal Ghanem, Marc El Beyrouthy, Carmen Sadaka, Samar Azzi-Achkouty, Nancy Nehme, Eda Sönmez Gürer and Javad Sharifi-Rad
    Citation: BMC Chemistry 2023 17:157
  40. This paper deals with the evaluation of novel imidazole molecules for their antimicrobial and larvicidal activities. A series of imidazole derivatives 1(af) and 2(ae) were prepared by the Mannich base technique...

    Authors: Janani Mullaivendhan, Idhayadhulla Akbar, Mansour K. Gatasheh, Ashraf Atef Hatamleh, Anis Ahamed, Mohamed Hussain Syed Abuthakir and Raman Gurusamy
    Citation: BMC Chemistry 2023 17:155
  41. In this pared, an efficient method is introduced for the synthesis of 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives. These novel products have both 1,2...

    Authors: Alireza Sherafati, Shahram Moradi and Mohammad Mahdavi
    Citation: BMC Chemistry 2023 17:154
  42. The ligand N-{[(phenyl amino) thioxomethyl] hydrazino carbonyl methyl} trimethyl ammonium chloride (PTHAC) was prepared by the refluxing phenyl isothiocyanate and Girard-T (trimethyl ammonium-acethydrazide) in...

    Authors: Magda A. Akl, Nora A. El Mahdy, Zizi Elbadrawy, Abdelrahman S. El-Zeny and Mohsen M. Mostafa
    Citation: BMC Chemistry 2023 17:153
  43. Recently, green analytical chemistry (GAC) is a key issue towards the idea of sustainability, the analytical community is focused on developing analytical methods that incorporate green chemistry principles to...

    Authors: Esraa S. Ashour, Maha A. Hegazy, Amal M. Abou Al-Alamein, Ghada M. El-Sayed and Nermine S. Ghoniem
    Citation: BMC Chemistry 2023 17:151
  44. In this work, we presented a synthesis of a composite based on HAp and PEG 6000 using a new method of synthesis dissolution precipitation to be applied for application of wastewater purification from toxic met...

    Authors: K. Azzaoui, S. Jodeh, E. Mejdoubi, B. Hammouti, M. Taleb, G. Ennabety, A. Berisha, M. Aaddouz, M. H. Youssouf, S. Shityakov, R. Sabbahi and M. Algarra
    Citation: BMC Chemistry 2023 17:150

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