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  1. To formulate a nanoformulation (PLGA-NPs) and to improve brain bioavailability for thymoquinone (THQ) through intranasal (i.n.) drug delivery, using a newly UHPLC-PDA developed the method and validated. Five d...

    Authors: Niyaz Ahmad, Rizwan Ahmad, Sadiq Al Qatifi, Mahdi Alessa, Hassan Al Hajji and Md Sarafroz

    Citation: BMC Chemistry 2020 14:10

    Content type: Research article

    Published on:

  2. Corydalis yanhusuo W.T. Wang alkaloids are mainly divided into three categories: protoberberine, prototropine and aporphine alkaloids. Therefore, we have taken into account these three alkaloid contents when extr...

    Authors: Yongping Zhang, Zuhua Wang, Jian Xu, Fangfang Yang, Chuanyang Dai, Weijie Xie, Zhu Liang and Songbo Su

    Citation: BMC Chemistry 2020 14:9

    Content type: Research article

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  3. Isolated bioactive components of plants or their raw extract are utilized as complementary or alternate remedy in copious illnesses. The current research was aimed at assessing the activity of aloin A isolated...

    Authors: Addai-Mensah Donkor, Martin Ntiamoah Donkor and Ngmenpone Kuubabongnaa

    Citation: BMC Chemistry 2020 14:8

    Content type: Research article

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  4. This study was conducted to evaluate the potential of pineapple peel (PP) and pineapple crown leaves (PCL) as the substrate for vanillic acid and vanillin production. About 202 ± 18 mg L−1 and 120 ± 11 mg L−1 of ...

    Authors: Pei Ling Tang and Osman Hassan

    Citation: BMC Chemistry 2020 14:7

    Content type: Research article

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  5. In the present study, we report the synthesis of various quinoxaline derivatives from direct condensation of substituted aromatic 1,2-diamine with 1,2-dicarbonyl catalyzed by nanostructured pyrophosphate Na2PdP2O

    Authors: Karim Dânoun, Younes Essamlali, Othmane Amadine, Hassan Mahi and Mohamed Zahouily

    Citation: BMC Chemistry 2020 14:6

    Content type: Research article

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  6. Extensive bioactivities of alkaloids from the genus Macleaya (Macleaya cordata (Willd.) R. Br. and Macleaya microcarpa (Maxim.) Fedde) have been widely reported, as well as more and more concerned from the scient...

    Authors: Chunmei Sai, Jian’an Wang, Binjie Li, Lin Ding, Huiyun Wang, Qibao Wang, Huiming Hua, Fangpeng Zhang and Qiang Ren

    Citation: BMC Chemistry 2020 14:5

    Content type: Research article

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  7. Zizania latifolia is easily lignified after harvesting, leading to the degradation of food quality and commercial value. Thus, this study evaluated the effect of radio frequency (RF) treatments on lignification i...

    Authors: Changwen Ye, Chen He, Bowen Zhang, Lixuan Wang and Lufeng Wang

    Citation: BMC Chemistry 2020 14:4

    Content type: Research article

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  8. A novel polystyrene sulfonate sodium (PSS) magnetic material was prepared by surface-initiated atom transfer radical polymerization (SI-ATRP). The starting materials were brominated magnetic material as the ca...

    Authors: Huachun Liu, Bolin Gong, Yanqiang Zhou, Zhian Sun, Xiaoxiao Wang and Shanwen Zhao

    Citation: BMC Chemistry 2020 14:3

    Content type: Research article

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  9. A new donor-π-acceptor derived from phenothiazine, namely 2-(2-((10-hexyl-10H-phenothiazin-3-yl)methylene)-3-oxo-2,3-dihydroinden-1-ylidene) malononitrile (PTZON) was synthesized and fully characterized, and i...

    Authors: Fatimah A. M. Al-Zahrani, Reda M. El-Shishtawy, Abdullah M. Asiri, Amerah M. Al-Soliemy, Khloud Abu Mellah, Nahed S. E. Ahmed and Abdesslem Jedidi

    Citation: BMC Chemistry 2020 14:2

    Content type: Research article

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  10. A hybrid magnetic material γFe2O3@Sh@cu2O was easily prepared from Shilajit (Sh) decorated Fe3O4 and copper acetate. The prepared magnetic hybrid material was fully characterized using different analysis, includi...

    Authors: Fereshteh Norouzi and Shahrzad Javanshir

    Citation: BMC Chemistry 2020 14:1

    Content type: Research article

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  13. Mainstream tobacco smoke is a complex and dynamic aerosol, consisting of particulate and vapour phases. Most approaches to determine mainstream smoke toxicant yields are based on offline techniques that limit ...

    Authors: Jenni Hawke, Graham Errington and Matthias Bente von Frowein

    Citation: BMC Chemistry 2019 13:135

    Content type: Research article

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  14. Safety, environmental and economic setbacks are driving industries to find greener approaches to extract bioactive compounds from natural resources. Pressurized hot water extraction (PHWE) is among the solvent...

    Authors: Noor Hidayah Mohd Jusoh, Atiqah Subki, Swee Keong Yeap, Ken Choy Yap and Indu Bala Jaganath

    Citation: BMC Chemistry 2019 13:134

    Content type: Research article

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  16. Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-...

    Authors: Mandlenkosi Robert Khumalo, Surya Narayana Maddila, Suresh Maddila and Sreekantha B. Jonnalagadda

    Citation: BMC Chemistry 2019 13:132

    Content type: Research article

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  17. The current work deals with fabrication and validation of a new highly Fe3+ selective sensor based on benzo-18-crown-6 (b-18C6) using the potentiometric method. The proposed sensor revealed satisfactory performan...

    Authors: Somayeh Badakhshan, Saeid Ahmadzadeh, Anoushiravan Mohseni-Bandpei, Majid Aghasi and Amir Basiri

    Citation: BMC Chemistry 2019 13:131

    Content type: Research article

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  18. The side reactions of dehalogenation or C–N coupling tend to occur when halogenated aromatic amines are prepared by catalytic hydrogenation reduction of halogenated aromatic nitro compounds. In this paper, we ...

    Authors: Haichang Guo, Renhua Zheng, Huajiang Jiang, Zhenyuan Xu and Aibao Xia

    Citation: BMC Chemistry 2019 13:130

    Content type: Research article

    Published on:

  19. In this work, using DNA and exonuclease-I (Exo-I) as signal amplification strategy, a novel and facile electrochemical aptasensor was constructed for fumonisin B1 (FB1) detection. The G-rich complementary DNA (cD...

    Authors: Min Wei, Fei Zhao, Shuo Feng and Huali Jin

    Citation: BMC Chemistry 2019 13:129

    Content type: Research article

    Published on:

  20. A form of β-glucosidase was isolated and purified from fresh Chrysanthemum morifolium (Ramat.) Tzvel. ‘Boju’ (Boju) and its enzymatic properties explored in this study. The purified enzyme and Boju flavonoids wer...

    Authors: Wei Zhang, Yafeng Zuo, Fengqing Xu, Tongsheng Wang, Jinsong Liu and Deling Wu

    Citation: BMC Chemistry 2019 13:128

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Chemistry 2020 14:16

  21. A series of Schiff bases (3.a–f) bearing benzimidazole moiety was successfully synthesized in ethanol by refluxing Oct-2-ynoic acid (1,3-dihydrobenzimidazole-2-ylidene)amide with substituted amines. Fourier trans...

    Authors: Thierry Youmbi Fonkui, Monisola Itohan Ikhile, Patrick Berka Njobeh and Derek Tantoh Ndinteh

    Citation: BMC Chemistry 2019 13:127

    Content type: Research article

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  22. Research inventories on the co-pyrolysis of major biomass components such as cellulose with amino acid materials is scarce in literature despite the fact that such studies are critical in understanding toxic p...

    Authors: Samuel K. Kirkok, Joshua K. Kibet, Francis Okanga, Thomas Kinyanjui and Vincent Nyamori

    Citation: BMC Chemistry 2019 13:126

    Content type: Research article

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  23. In situ analysis of odor is an important approach to connect odor with chemical composition. However, it is difficult to conduct a rapid direct analysis of the odor sample because of low analyte concentration ...

    Authors: Shihao Sun, Yihan Zhang, Peng Li, Hui Xi, Lei Wu, Jianxun Zhang, Guixin Peng and Yue Su

    Citation: BMC Chemistry 2019 13:125

    Content type: Research article

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  24. New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.

    Authors: Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade and Aida Habib

    Citation: BMC Chemistry 2019 13:124

    Content type: Research article

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  25. Baricitinib, with a 2-(1-(ethylsulfonyl)azetidin-3-yl)acetonitrile moiety at N-2 position of the pyrazol skeleton, is an oral and selective reversible inhibitor of the JAK1 and JAK2 and displays potent anti-infla...

    Authors: Xin Cui, Junming Du, Zongqing Jia, Xilong Wang and Haiyong Jia

    Citation: BMC Chemistry 2019 13:123

    Content type: Research article

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  26. Current methods of removing organic pollutants from water are becoming ineffective as the world population increases. In this study, a series of biorenewable triblock copolymers with hydrophobic poly(ε-caprola...

    Authors: Katrina T. Bernhardt, Haley G. Collins and Amy M. Balija

    Citation: BMC Chemistry 2019 13:122

    Content type: Research article

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  27. The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD)...

    Authors: Haitham AlRabiah, Mohammed Abounassif, Haya I. Aljohar and Gamal Abdel-Hafiz Mostafa

    Citation: BMC Chemistry 2019 13:121

    Content type: Research article

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  28. Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as a superior catalyst has been used for the synthesis of 3-alkyl-4-phenyl-1,3-thiazole-2(3H)-thione derivatives through a three-compo...

    Authors: Hossein Shahbazi-Alavi, Sheida Khojasteh-Khosro, Javad Safaei-Ghomi and Maryam Tavazo

    Citation: BMC Chemistry 2019 13:120

    Content type: Research article

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  29. The synthesized Fe3O4@l-arginine showed strong catalytic performance in the one-pot synthesis of spiropyranopyrazoles via the reactions of hydrazines, β-keto esters, isatins, and malononitrile or ethyl cyanoaceta...

    Authors: Mohammad Ali Ghasemzadeh, Boshra Mirhosseini-Eshkevari and Mohammad Hossein Abdollahi-Basir

    Citation: BMC Chemistry 2019 13:119

    Content type: Research article

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  30. In the present study two different RSLC columns, Acclaim RSLC 120 C18, 5.0 µm, 4.6 × 150 mm (column A) and Acclaim RSLC 120 C18, 2.2 µm, 2.1 × 100 mm (Column B) were utilized for the analysis of velpatasvir (V...

    Authors: Moustapha Eid Moustapha, Rania Mohamed El-Gamal and Fathalla Fathalla Belal

    Citation: BMC Chemistry 2019 13:118

    Content type: Research article

    Published on:

  31. The transcription factor Nuclear factor erythroid-2-related factor 2 (NRF2) and its principal repressive regulator, Kelch-like ECH-associated protein 1 (KEAP1), are perilous in the regulation of inflammation, ...

    Authors: Murugesh Kandasamy, Kit-Kay Mak, Thangaraj Devadoss, Punniyakoti Veeraveedu Thanikachalam, Raghavendra Sakirolla, Hira Choudhury and Mallikarjuna Rao Pichika

    Citation: BMC Chemistry 2019 13:117

    Content type: Research article

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  32. Pyrazoles, thiazoles and fused thiazoles have been reported to possess many biological activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a,b (obtained from the reaction of ...

    Authors: Abdelwahed R. Sayed, Sobhi M. Gomha, Fathy M. Abdelrazek, Mohamed S. Farghaly, Shaimaa A. Hassan and Peter Metz

    Citation: BMC Chemistry 2019 13:116

    Content type: Research article

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  33. 2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis of diverse range of heterocyclic analogues with promising therapeutic roles as antibacteria...

    Authors: Saima Ejaz, Humaira Nadeem, Rehan Zafar Paracha, Sadia Sarwar and Sadaf Ejaz

    Citation: BMC Chemistry 2019 13:115

    Content type: Research article

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  34. Natural Bombyx mori silk fibroin (SF) fibers were modified with 2-methacryloyloxyethyl isocyanate (MOI) first for the introduction of vinyl groups. Then, 1H,1H,2H,2H-perfluorodecanethiol was grafted onto the SF f...

    Authors: Xiaoning Zhang, Jianwei Liang, Zhenyu Chen, Carrie Donley, Yuling Liu and Guotao Cheng

    Citation: BMC Chemistry 2019 13:114

    Content type: Research article

    Published on:

  35. In the present study, a series of 2-(4-(2-chloroacetyl)piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives was synthesized and its chemical structures were confirmed by physicoche...

    Authors: Shinky Mehta, Sanjiv Kumar, Rakesh Kumar Marwaha, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:113

    Content type: Research article

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  36. Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the di...

    Authors: Li Xu, Yanli Wen, Santosh Pandit, Venkata R. S. S. Mokkapati, Ivan Mijakovic, Yan Li, Min Ding, Shuzhen Ren, Wen Li and Gang Liu

    Citation: BMC Chemistry 2019 13:112

    Content type: Mini review

    Published on:

  39. In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (T...

    Authors: Chunhong Dong, Shuanglin Liu, Xiaodong Cheng, Qiang Wang, Shiqing Jiang and Guoqing Wang

    Citation: BMC Chemistry 2019 13:109

    Content type: Research article

    Published on:

  40. The leaves and bark of Syringa oblata Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing and jaundice-relieving effects. There are many studies about leaves of S. oblata becau...

    Authors: Lili Cui, Miyun Hu, Pengran Cao, Yun Niu, Changqin Li, Zhenhua Liu and Wenyi Kang

    Citation: BMC Chemistry 2019 13:108

    Content type: Research article

    Published on:

  41. The main objective of this study is treatment and characterization of phosphorus from synthetic wastewater using aluminum electrodes in the electrocoagulation process. EC experimental setups were designed and ...

    Authors: Dessie Tibebe, Yezbie Kassa and Ashok N. Bhaskarwar

    Citation: BMC Chemistry 2019 13:107

    Content type: Research article

    Published on:

  42. Cannabis products (marijuana, weed, hashish) are among the most widely abused psychoactive drugs in the world, due to their euphorigenic and anxiolytic properties. Recently, hair analysis is of great interest ...

    Authors: Iltaf Shah, Bayan Al-Dabbagh, Alaa Eldin Salem, Saber A.A. Hamid, Neak Muhammad and Declan P. Naughton

    Citation: BMC Chemistry 2019 13:106

    Content type: Review

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  44. Tartrazine (Yellow 5 or E102) is a synthetic food dye able to modify perception and behavior, causing agitation, confusion, rhinitis and can produce hyperactivity syndrome in children when is combined with ben...

    Authors: Igori Balta, Bogdan Sevastre, Vioara Mireşan, Marian Taulescu, Camelia Raducu, Adina Lia Longodor, Zamfir Marchiş, Codruta Stefania Mariş and Aurelia Coroian

    Citation: BMC Chemistry 2019 13:104

    Content type: Research article

    Published on:

  46. We have synthesized new series of bisindole analogs (1–27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 ...

    Authors: Muhammad Taha, Imad Uddin, Mohammed Gollapalli, Noor Barak Almandil, Fazal Rahim, Rai Khalid Farooq, Muhammad Nawaz, Mohamed Ibrahim, Mohammed A. Alqahtani, Yasser A. Bamarouf and Manikandan Selvaraj

    Citation: BMC Chemistry 2019 13:102

    Content type: Research article

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  48. Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compound...

    Authors: Btissam Bouchal, Farid Abrigach, Abdelilah Takfaoui, Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Pierre H. Dixneuf, Henri Doucet, Rachid Touzani and Mohammed Bellaoui

    Citation: BMC Chemistry 2019 13:100

    Content type: Research article

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  49. Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, to simplify prescribing and to improve patient comp...

    Authors: Christine M. El-Maraghy and Nesrine T. Lamie

    Citation: BMC Chemistry 2019 13:99

    Content type: Research article

    Published on:

  50. Sevelamer (polyallyamine resin)-supported sulfonic acid (S-SO3H) has been prepared from the reaction of sevelamer with chlorosulfonic acid and characterized using FT-IR spectroscopy, scanning electronmicroscopy (...

    Authors: Xian-Liang Zhao, Makombe Shelton and Ke-Fang Yang

    Citation: BMC Chemistry 2019 13:98

    Content type: Research article

    Published on:

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