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Lanthanum-based metal organic framework (La-MOF) use of 3,4-dihydroxycinnamic acid as drug delivery system linkers in human breast cancer therapy


Metal organic frameworks (MOFs) have received a lot of attention in the research community due to their unique physical properties, which make them ideal materials for targeted drug delivery systems. In this paper, we describe the synthesis of a non-toxic La-based MOF with 3,4-dihydroxycinnamic acid (3,4-DHCA) as a linker. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), nitrogen adsorption–desorption measurements, and X-ray powder diffraction (XRD) have all been used to characterize it thoroughly. The La-based MOF showed good biocompatibility with the human breast cancer cell line MDA-MB-468. The ability of 3,4-DHCA to treat MDA-MB-468 cells was confirmed by 40.35% cell viability with La-based MOF. Based on the findings, La-based MOF can be recommended as a promising candidate for anticancer delivery.

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A group of lattice solids characterized by crystallization and porosity are called metal–organic frameworks (MOF), and major research has been done on the shape, surface, and pore measurements [1, 2]. The MOF compounds are the result of the binding of metal cations by organic ligands and are used in various fields, including drug delivery [3], gas storage [4], luminescent [5] and anticancer [6]. Due to the adjustable construction and chemical properties that change and function, MOF has many advantages over other drug delivery systems [7,8,9]. However, the high porosity and large surface area of MOFs have resulted in high loading and adsorption capacity, so poor coordination interaction ensures the biodegradability of MOFs [10]. MOFs have a major impact on colloid stability, cell uptake, and drug release profiles, [11, 12]which is highly desirable for pharmaceutical applications due to its surface properties and size [13]. MOFs have anti-cancer properties, for example Cu-MOF [14], Al-MOF [15], Sr-MOF [16], Co-MOF [17], Zn-MOF [18] and Zr-MOF [19] mentioned. Several research articles have recently reported on MOF and MOF-derived nanocomposites as gas sensor [20,21,22]. Nguyen and coworkers developed porous zeolitic imidazolate frameworks for fluorescent chemosensors [23], and the same group developed Zr-MOF as a nano adsorbent to remove toxic organic dye for water remediation [24]. Dang and coworkers developed Hf-MOF and Fe(III)-MOF using a one-pot three-component reaction with high porosity and surface area for catalytic applications [25, 26].

3,4-Dihydroxycinnamic acid contributes to plant defence mechanisms against predators, pests, and infections by inhibiting the growth of insects, fungi, and bacteria and promoting the protection of plant leaves against ultraviolet radiation B (UV-B) [27, 28]. CA and its derivatives have been studied in vitro and in vivo, and numerous physiological effects, such as antibacterial [29, 30], anti-hepatocarcinoma (HCC) [31], antioxidant [30, 32, 33], anti-inflammatory [30, 32, 33], anticancer [32, 33], and anti-hepatocellular carcinoma activity [34] have been demonstrated. HCC (hepatocellular carcinoma) is one of the leading causes of cancer death worldwide, hence anti-HCC activity is essential [35]. As a result, additional research on the chemical and pharmacological properties of CA is required to contribute to the future development of a novel medicine and, as a result, the extension of therapeutic possibilities [31]. Recently, Rao and coworkers have reviewed the development of MOFs for both in vivo and in vitro drug delivery application [36]. Chemodynamic therapy (CDT) and chemo photodynamic therapy (CPT), which inhibits tumors cell growth and division, are recognized as a potential pharmacological technique used to treat cancer [37, 38]. Tan and coworkers evaluated and discussed various MOFs for their CDT use [39]. Table 1 lists various MOFs and their preparation routes, crystallite size, BET surface area, and action on cell lines.

Table 1 MOFs and their anticancer activities on various cell lines

Lanthanum has recently been reported as an effective drug for the treatment of malignant tumors. For example, in human cervical carcinoma cells, lanthanum complex has shown significant cytotoxicity in the laboratory [45,46,47]. LaCl3 also reduced the growth and triggered apoptosis in leukemia cell lines, HL-60 and NB4 [48]. Furthermore, lanthanum has been linked to the inhibition of human stomach cancer cells' proliferation [49]. All of these findings revealed that lanthanum, a rare earth element, has the ability to regulate tumor growth [50].

In this study, lanthanum-MOFs (La-MOFs) with linkers of 3,4-dihydroxycinnamic acid (3,4-DHCA) was prepared with a ultrasonic reverse micelle assisted. it was characterized using XRD, TEM, EDS and TGA. It was also tested for anticancer properties.


Materials and apparatus

Sigma-Aldrich Corporation was chosen to purchase C12H25NaSO4 (sodium dodecyl sulfate) and 8 mL of C6H14. Merck & Co., Inc. was selected to prepare La(NO3)3∙6H2O (lanthanum nitrate hexahydrate) and C9H8O4 (3,4-dihydroxycinnamic acid).

Each material has been of analytical grade with the increased purity. The Iranian Biological Resource Center (IBRC; Tehran, Iran) provided a human breast cancer (MDA-MB-468) cell line. Trypsin/EDTA solution, 3-(4,5-dimetylthiazol-2-Yl)–2,5–diphenyltetrazolium bromide (MTT), Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum (FBS), phosphate-buffered saline (PBS), and dimethyl sulfoxide (DMSO) were acquired from Gibco BRL and Sigma, respectively. They were developed in DMEM (Gibco, UK) supplemented with 10% FBS (Gibco) and 1% penicillin–streptomycin (Gibco) and incubated at 37 °C in a 5% CO2 environment. During the synthesis of MOF, X-ray diffraction (XRD) was used to analyze and determine the crystalline structure and phases. To accomplish this goal, a powder X-ray diffractometer (Expert MPD, pananalytical, CuK = 0.154.6 nm) was employed in the 2θ = 0–50 degree range with a step width of 0.01 degree. The surface morphology was investigated using a scanning electron microscope (FESEM, FEI Nanosem 450). Adsorption/desorption measurements (BET, Belsorp mini II) at 77 K in N2 environment were used to assess the porosities, surface area, and pore textural features of samples. Under an Argon environment, thermogravimetric analysis (TGA, TA Q600 USA) was performed from room temperature to 400 °C at a heating rate of 10 °C/min. The cell viability was determined using an ELISA reader (Bio-Tek, Elx 808, Germany) at k = 545 nm.

Preparation of aqueous extract of satureja hortensis

To make S. hortensis aqueous extract, combine 25 g of dry Satureja cut (harvested from Golboft in Kerman province of Iran, 2018) in clevenger-type apparatus with 250 mL of distilled water for 1.5 h, then cool and filter three times with centrifugal spinning machine at 3000 rpm. The extract was kept in refrigerator for future uses.

We confirmed that all the relevant permission to collect S. hortensis were obtained from the governing body. We are thankful to Prof. Gholamhossein Shahidi Bonjar who undertook the formal identification of the S. hortensis used in our study. The voucher ID for this plant was 18/D3713.

Synthesis of La-based MOF

During the preparation of the specimens using the ultrasonic aided approach, La(NO3)3.6H2O (Control group: 19.0 g NaCl, 16.0 g KCl, 3.0 g C5H8NO4Na and 1.1 g C12H22O11). and 3,4-DHCA were mixed with 1:1 mmol and dissolved in 21 mL of double distilled water. The resultant solution was mixed with 0.077 mmol sodium dodecyl sulphate and 8 mL hexane. The resulting mixture was then agitated for 1 h at 85 °C. The obtained solution was placed in the ultrasonic device and exposed to ultrasonic irradiation under optimal conditions, which included an ultrasonic time of 21 min, an ultrasonic temperature of 40 °C, and a power of 175 W. After 30 min, La-MOF crystals develop, which are centrifuged and washed with DMF. Using 75% of the ultrasonic power at 80 °C, a very high yield of 92.31% La-MOF was obtained.


To begin treatment, 5 × 103 cells/well were seeded in 96-well flat-bottomed plates overnight; the cells were then subjected to different doses of the herbal extract (0–100.0 M) and La-based MOF (0–100.0 M) for 48 h. After removing the medium, 200 μL of MTT solution (5 mg/mL in PBS) was applied to each well and incubated for 4 h at 37 °C. Following the removal of the solution, 100 μL of DMSO was added to the plates, which were shaken for 15 min. Using an ELISA microplate reader, the absorbance of each sample was measured at 570 nm. The results were expressed as a percentage of cell viability compared to untreated control cells.


The surface morphology of the La-based MOF was studied by SEM micrograph (Fig. 1A and B). The crystallite size, phase structure and crystallinity of the La-based MOF were studied by XRD analysis. The XRD spectrum of La-based MOF is shown in Fig. 1C. The thermogravimetric analysis of the La-based MOF was carried out to determine the exact temperature needed for its decomposition. This could be further experimentally confirmed by the EDX elemental analysis of the sample shown in Fig. 2. Figure 3 illustrates the thermal analysis of La-based MOF as a final product. N2 adsorption–desorption analysis was used to explore the textural features of La-based MOF.

Fig. 1
figure 1

A FE-SEM image and B TEM image. C XRD pattern D FT-IR spectrum of the La-based MOF

Fig. 2
figure 2

EDX map images of La-based MOF. Inset: Digital photograph of a dragon's head

Fig. 3
figure 3

Thermal gravimetric analysis (TGA) and derivative thermogravimetric analysis (DTG) curves of La-based MOF

Figure 5 shows how the MTT test was used to assess the anticancer activity of the La-based MOF and 3,4-DHCA in a human breast cancer cell line in vitro.


Characterization of the La-based MOF

In the SEM image of La-based MOF can be seen uniform surface morphology (Fig. 1A). Besides, the TEM image of La-based MOF displayed that the surface of La-based MOF was uniform with many cavities in the internal zones. Therefore, this structure is capable to diffuse water into the beads and release the 3,4-DHCA (Fig. 1B).

The seven characteristic diffraction peaks of La-based MOF appeared at 2θ = 14.95°, 20.29°, 25.27°, 30.19°, 33.28°, 35.56° and 36.80° (Reference code: 96–450-4165) (Fig. 1C). No extra-diffraction peak in the XRD spectrum confirms the excellent purity and crystallinity of the La-based MOF. The crystallite size of the synthesized La-based MOF was estimated by Debye–Scherrer formula (Eq. 1).

$$\mathrm{D }= \frac{0.9\uplambda }{\beta cos\theta }$$

Here, λ stands for the wavelength of X-ray (1.54056 Å for Cu lamp), θ stands for half of the Bragg diffraction angle and β stands for half of the width of maximum intensity diffraction peak. The mean crystallite size of La-based MOF was 42 nm.

The FTIR spectrum of La-MOF is depicted in Fig. 1D. The La-MOF structure contains surface water, which causes the O–H broad stretching band to appear at 3387 cm−1. C–H stretching is responsible for a sharp band at 2911 cm−1. The bands shown at 1602 and 1377 cm−1 are attributed to the coordinated carboxylate's asymmetrical and symmetrical stretching modes, respectively. According to C–O stretching in La-MOF, a band that developed at 1139 cm−1.

As seen in Fig. 2, the EDS mapping images for La-based MOF confirmed uniformly dispersion of each lanthanum, carbon and oxygen elements. If we consider the shape of the MOF as a dragon head, the distributions of the elements are as follows: the scattering of lanthanum is regularly on the dragon head and the carbon is evenly distributed on the background of the dragon head and the oxygen is evenly distributed throughout.

TGA-DTA thermograms for La-based MOF is shown in Fig. 3. La-MOF exhibit a two stage decomposition process. The first stage decomposition starts at 150–204 °C, which may be due to removal of bound water and carboxylate groups as CO2 present in the La-MOFs. In the second stage, the main decomposition starts at 270 °C and end up at 450 °C, which corresponds to the loss of side chain attached to the aromatic nucleus. La-MOF exhibits reasonable thermal stability even at high temperatures, as confirmed by TGA and DTA data.

Figure 4a depicts type IV hysteresis loops in the prepared La-based MOF. This isotherm demonstrates the mesoporous structure of the material and the parallel plate shaped pore. The obtained structural parameters such as BET surface area and pore volume of the La-based MOF were 521 m2.g−1 and 0.075 cm3.g−1, respectively. Figure 4B illustrates the pore size distribution of the La-based MOF samples on the basis of the Barrett–Joyner–Halenda (BJH) method. This figure also illustrates that the mean pore size distribution of the La-based MOF samples is 8.3 nm, which means the microporous size distributions of the products. It may be an indicative that the La-based MOF remained a wide pore opening and a high porosity, leading to the La-based MOF is one of the best carrier.

Fig. 4
figure 4

A N2 adsorption–desorption isotherms La-based MOF; B BJH results obtained for La-based MOF

In vitro cytotoxicity studies

The values of cell viability found for the La-based MOF and 3,4-DHCA are 40.35% and 68.29%, respectively. Figure 5 shows that the La-based MOF antitumor behavior is greater compared to the 3,4-DHCA. La-based MOF passes through the cell membrane more easily than 3,4-DHCA. Thus, it facilitates the penetration of La-based MOF into cancer cells while improving its antitumor behavior. The anticancer behavior of La-based MOF may be described according to the concept of chelation. The polarity of metal ions may be significantly reduced by chelation because the positive charge is partly shared with the donor groups and also due to the displacement of electrons in the chelate ring. The concentration of metal ions may be exacerbated by the lipophilic properties of chelates and the interaction between the cell wall and metal ions. The geometries and charge dispersion of the La-based MOF molecule are compatible with the cancer cell wall, which increases penetration through the cell wall. Such a unique structural arrangement can break down the cell’s permeability barrier and disrupt the normal process of the cell.

Fig. 5
figure 5

Plots of percentage of cytotoxicity vs. concentrations of the 3,4-DHCA (0–100.0 μM) and La-based MOF (0–100.0 μM) against human breast cancer cells after incubation for 48 h


Summery, in the first step, La-based MOF was prepared and characterized. The preparation of La-based MOF was approved by the SEM, TEM, EDX, TGA, BET and XRD analysis. In addition, in vitro anticancer activity results showed that La-based MOF can inhibit the growth of MDA-MB-468 cells line as a human breast cancer cell. The anticancer activity of the La-based MOF was more than in the 3,4-DHCA. Based upon the results of corresponding experiments, La-based MOF exhibited high 3,4-DHCA drug loading, cancer-targeted release and good biocompatibility, which can be used as a good candidate for anticancer drug delivery system.

Availability of data and materials

The datasets used and/or analyzed during the current study available from the corresponding author on request. We confirms all the relevant permission to collect sample were obtained from governing body.


  1. Hu P, Morabito J, Tsung C. ACS Catal. 2014, 4, 4409.(d) Furukawa, H.; Cordova, KE; O’Keeffe, M.; Yaghi, OM. Science. 2013;341:1230444.

    Google Scholar 

  2. Gelfand BS, Taylor JM, Shimizu GK. Extracting structural trends from systematic variation of phosphonate/phosphonate monoester coordination polymers. CrystEngComm. 2017;19(27):3727–36.

    Article  CAS  Google Scholar 

  3. Osterrieth JW, Fairen-Jimenez D. Metal-organic framework composites for theragnostics and drug delivery applications. Biotechnol J. 2021;16(2):2000005.

    Article  CAS  Google Scholar 

  4. Chen S, Li Y, Mi L. Porous carbon derived from metal organic framework for gas storage and separation: the size effect. Inorg Chem Commun. 2020;118: 107999.

    Article  CAS  Google Scholar 

  5. Brunckova H, et al. Preparation and characterization of isostructural lanthanide Eu/Gd/Tb metal-organic framework thin films for luminescent applications. Appl Surf Sci. 2021;542: 148731.

    Article  CAS  Google Scholar 

  6. Ahmadijokani F, et al. Aluminum-based metal-organic frameworks for adsorptive removal of anti-cancer (methotrexate) drug from aqueous solutions. J Environ Manage. 2021;277: 111448.

    Article  CAS  PubMed  Google Scholar 

  7. Zhou T, Li J, Liu P. Ionically crosslinked alginate-based nanohydrogels for tumor-specific intracellular triggered release: effect of chemical modification. Colloids Surf, A. 2018;553:180–6.

    Article  CAS  Google Scholar 

  8. Li X, et al. Preparation and characterization of a pH-responsive mesoporous silica nanoparticle dual-modified with biopolymers. Colloids Surf A. 2018;548:61–9.

    Article  CAS  Google Scholar 

  9. Jiang Q, et al. Planar-structure perovskite solar cells with efficiency beyond 21%. Adv Mater. 2017;29(46):1703852.

    Article  Google Scholar 

  10. He Z, et al. Hybrid nanomedicine fabricated from photosensitizer-terminated metal-organic framework nanoparticles for photodynamic therapy and hypoxia-activated cascade chemotherapy. Small. 2019;15(4):1804131.

    Article  Google Scholar 

  11. Dang YT, et al. Microwave-assisted synthesis of nano Hf-and Zr-based metal-organic frameworks for enhancement of curcumin adsorption. Microporous Mesoporous Mater. 2020;298: 110064.

    Article  CAS  Google Scholar 

  12. Nguyen LH, et al. Pore engineering of biomolecule-based metal–organic framework nanocarriers for improving loading and release of paclitaxel. New J Chem. 2022;46(14):6630–5.

    Article  CAS  Google Scholar 

  13. Wang H, et al. One-pot synthesis of poly (ethylene glycol) modified zeolitic imidazolate framework-8 nanoparticles: size control, surface modification and drug encapsulation. Colloids Surf A. 2019;568:224–30.

    Article  CAS  Google Scholar 

  14. Liu W, et al. A porous Cu (II)-based metal-organic framework carrier for pH-controlled anticancer drug delivery. Inorg Chem Commun. 2020;111: 107675.

    Article  CAS  Google Scholar 

  15. Zeraati M, et al. Green synthesis and mechanism analysis of a new metal-organic framework constructed from Al (III) and 3, 4-dihydroxycinnamic acid extracted from satureja hortensis and its anticancerous activities. J Mol Str. 2021;1250: 131712.

    Article  Google Scholar 

  16. Feng X-E, Zhu T-T. A porous Sr (II)-organic framework for 5-fluorouracil delivery and anti-cancer activity against human melanoma cells. Inorg Nano Metal Chem. 2020;50(12):1302–7.

    Article  CAS  Google Scholar 

  17. Xi Y, et al. A New Co (II)-based metal-organic framework for size-selective cyanosilylation reaction and anti-cancer activity against lung cancer cell via inducing apoptosis. J Inorg Organomet Polym Mater. 2020;30(6):2204–12.

    Article  CAS  Google Scholar 

  18. Akhavan-Sigari R, et al. Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF. BMC Chem. 2022;16(1):1–7.

    Article  Google Scholar 

  19. Hassabo AA, et al. Immobilization of l-methioninase on a zirconium-based metal–organic framework as an anticancer agent. J Mater Chem B. 2019;7(20):3268–78.

    Article  CAS  Google Scholar 

  20. Doan TLH, et al. Preparation of n-ZnO/p-Co3O4 heterojunctions from zeolitic imidazolate frameworks (ZIF-8/ZIF-67) for sensing low ethanol concentrations. Sens Actuators B Chem. 2021;348:130684.

    Article  CAS  Google Scholar 

  21. Doan TLH, et al. Facile synthesis of metal-organic framework-derived ZnO/CuO nanocomposites for highly sensitive and selective H2S gas sensing. Sens Actuators B Chem. 2021;349:130741.

    Article  CAS  Google Scholar 

  22. Lee J-H, et al. Functionalization of zirconium-based metal–organic frameworks for gas sensing applications. J Hazard Mater. 2021;403:124104.

    Article  CAS  PubMed  Google Scholar 

  23. Nguyen DT, et al. Zeolitic imidazolate frameworks as an efficient platform for potential curcumin-based on/off fluorescent chemosensor. Microporous Mesoporous Mater. 2021;327: 111445.

    Article  CAS  Google Scholar 

  24. Nguyen LHT, et al. Microwave-assisted solvothermal synthesis of defective zirconium-organic framework as a recyclable nano-adsorbent with superior adsorption capacity for efficient removal of toxic organic dyes. Colloid Interface Sci Commun. 2022;46: 100511.

    Article  CAS  Google Scholar 

  25. Dang M-HD, et al. Using sulfate-functionalized Hf-based metal–organic frameworks as a heterogeneous catalyst for solvent-free synthesis of pyrimido [1, 2-a] benzimidazoles via one-pot three-component reaction. J Ind Eng Chem. 2021;103:340–7.

    Article  Google Scholar 

  26. Dang M, et al. Effect of Fe (III)-based MOFs on the catalytic efficiency of the tandem cyclooxidative reaction between 2-aminobenzamide and alcohols. New J Chem. 2020;44(34):14529–35.

    Article  CAS  Google Scholar 

  27. Tošović J. Spectroscopic features of caffeic acid: theoretical study. Kragujevac J Sci. 2017;39:99–108.

    Article  Google Scholar 

  28. Gould KS, et al. Functional role of anthocyanins in the leaves of Quintinia serrata A. Cunn. J Exp Bot. 2000;51(347):1107–15.

    Article  CAS  PubMed  Google Scholar 

  29. Verma RP, Hansch C. An approach towards the quantitative structure–activity relationships of caffeic acid and its derivatives. ChemBioChem. 2004;5(9):1188–95.

    Article  CAS  PubMed  Google Scholar 

  30. Genaro-Mattos TC, et al. Antioxidant activity of caffeic acid against iron-induced free radical generation—a chemical approach. PLoS ONE. 2015;10(6): e0129963.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Zhang Z, et al. Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid. Sci Rep. 2017;7(1):1–10.

    Google Scholar 

  32. Huang Q, Lin Y, Yan Y. Caffeic acid production enhancement by engineering a phenylalanine over-producing Escherichia coli strain. Biotechnol Bioeng. 2013;110(12):3188–96.

    Article  CAS  PubMed  Google Scholar 

  33. Lin Y, Yan Y. Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex. Microb Cell Fact. 2012;11(1):1–9.

    Article  Google Scholar 

  34. Gu W, et al. Caffeic acid attenuates the angiogenic function of hepatocellular carcinoma cells via reduction in JNK-1-mediated HIF-1α stabilization in hypoxia. RSC Adv. 2016;6(86):82774–82.

    Article  CAS  Google Scholar 

  35. McGlynn KA, Petrick JL, London WT. Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability. Clin Liver Dis. 2015;19(2):223–38.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Rao C, et al. Novel formulations of metal-organic frameworks for controlled drug delivery. Exp Opin Drug Del. 2022;19:1–20.

    Article  Google Scholar 

  37. Ding Q, et al. A multimodal metal-organic framework based on unsaturated metal site for enhancing antitumor cytotoxicity through chemo-photodynamic therapy. J Colloid Interface Sci. 2022;621:180–94.

    Article  CAS  PubMed  Google Scholar 

  38. Pan Y, et al. A versatile and multifunctional metal–organic framework nanocomposite toward chemo-photodynamic therapy. J Solid State Chem. 2020;49(16):5291–301.

    CAS  Google Scholar 

  39. Tan X, et al. Recent advances in nano-architectonics of metal-organic frameworks for chemodynamic therapy. J Solid State Chem. 2022;314:123352.

    Article  CAS  Google Scholar 

  40. Saleh RO, et al. Synthesis of bioactive yttrium-metal–organic framework as efficient nanocatalyst in synthesis of novel pyrazolopyranopyrimidine derivatives and evaluation of anticancer activity. Front Chem. 2022;10:743.

    Article  Google Scholar 

  41. El-Bindary MA, El-Desouky MG, El-Bindary AA. Metal–organic frameworks encapsulated with an anticancer compound as drug delivery system: Synthesis, characterization, antioxidant, anticancer, antibacterial, and molecular docking investigation. Appl Organomet Chem. 2022;36(5):e6660.

    Article  CAS  Google Scholar 

  42. El-Bindary AA, et al. Metal–organic frameworks as efficient materials for drug delivery: synthesis, characterization, antioxidant, anticancer, antibacterial and molecular docking investigation. Appl Organomet Chem. 2020;34(11):e5905.

    Article  CAS  Google Scholar 

  43. Kim K, et al. MOF× biopolymer: collaborative combination of metal–organic framework and biopolymer for advanced anticancer therapy. ACS Appl Mater Interfaces. 2019;11(31):27512–20.

    Article  CAS  PubMed  Google Scholar 

  44. Liu W, et al. A porous Cu (II)-based metal-organic framework carrier for pH-controlled anticancer drug delivery. Inorg Chem Commun. 2020;111:107675.

    Article  CAS  Google Scholar 

  45. Kapoor S. Lanthanum and its rapidly emerging role as an anti-carcinogenic agent. J Cell Biochem. 2009;106(2):193–193.

    Article  CAS  PubMed  Google Scholar 

  46. Durgo K, et al. Cytotoxic and genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells in vitro. Arh Hig Rada Toksikol. 2011;62(3):221–6.

    Article  CAS  PubMed  Google Scholar 

  47. Shen L, et al. Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells. Biometals. 2010;23(6):1179–89.

    Article  CAS  PubMed  Google Scholar 

  48. Dai Y, et al. Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In Vitro Cell Dev Biol Anim. 2002;38(7):373–5.

    Article  CAS  PubMed  Google Scholar 

  49. Shi P, Huang Z. Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells. Biometals. 2005;18(1):89–95.

    Article  CAS  PubMed  Google Scholar 

  50. Zhang J, et al. Recent progress in therapeutic and diagnostic applications of lanthanides. Mini Rev Med Chem. 2011;11(8):678–94.

    Article  CAS  PubMed  Google Scholar 

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The authors would like to acknowledge from the Bam University of Medical Sciences.


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MS: methodology, software, visualization. AR: methodology, software, visualization. MZ: methodology, software, writing—original visualization. ZH: writing—reviewing and editing investigation. SJ: writing—reviewing and editing investigation. NPSC: writing—original, visualization, writing—reviewing and editing investigation. GS: conceptualization, methodology, software, writing—original, visualization, writing- reviewing and editing investigation, data curation, validation, supervision. All the authors read and approved the final manuscript.

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Correspondence to Ghasem Sargazi.

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All methods were used in accordance with relevant guidelines and regulations. Also, we confirmed that all experimental protocols were approved by the Ethics Licensing Committee of the Bam University of Medical Sciences (no. 06 on 17/03/2021). MCF-7 cells were isolated from the pleural effusion of a 58-year-old woman with metastatic disease. In addition, informed consent was obtained from all study participants. We confirm that all the experimental research and field studies on wild plant satureja hortensis, including the collection of plant material, were carried out in accordance with relevant institutional, national, and international guidelines and legislation.

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Safinejad, M., Rigi, A., Zeraati, M. et al. Lanthanum-based metal organic framework (La-MOF) use of 3,4-dihydroxycinnamic acid as drug delivery system linkers in human breast cancer therapy. BMC Chemistry 16, 93 (2022).

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