From: Synthesis and therapeutic potential of imidazole containing compounds
Compounds | Substituent R | Substituent R1 | Molecular formula | IC50 ± SD (µM) | |
---|---|---|---|---|---|
MCF-7 | CaCo-2 | ||||
(a) | |||||
29a | H |
| C17H13N5 | 8.22 ± 1.48 | 5.67 ± 1.25 |
29b | H |
| C16H12N6 | 10.43 ± 1.45 | 9.56 ± 1.33 |
29c | H |
| C19H17N5O2 |  > 30 | 28.40 ± 2.48 |
29d | H |
| C18H14ClN5O | 13.05 ± 2.07 | 12.33 ± 1.80 |
29e | H |
| C25H17N5 |  > 30 ± 2.87 |  > 30 ± 2.98 |
29f | CH3 |
| C18H15N5 |  > 30 ± 2.66 |  > 30 ± 2.43 |
29Â g | CH3 |
| C17H14N6 | 18.56 ± 2.82 | 16.23 ± 1.24 |
29Â h | CH3 |
| C19H16ClN5O |  > 30 ± 2.19 | 25.50 ± 2.74 |
29i | CH3 |
| C20H19N5O2 | 25.11 ± 2.44 | 21.89 ± 2.35 |
29j | CH3 |
| C26H19N5 |  > 30 ± 2.80 |  > 30 ± 2.06 |
Fluorouracil |  |  |  | 7.26 ± 2.30 | 5.23 ± 2.36 |
(b) | |||||
---|---|---|---|---|---|
30a | H |
| C22H16N4 | 22.65 ± 2.32 | 28.45 ± 2.59 |
30b | H |
| C21H15N5 | 12.79 ± 2.20 | 9.788 ± 1.48 |
30c | H |
| C23H17ClN4O |  > 30 ± 2.86 |  > 30 ± 2.48 |
30d | H |
| C24H20N4O2 | 15.34 ± 2.67 | 13.27 ± 1.56 |
30e | H |
| C30H20N4 |  > 30 ± 2.52 |  > 30 ± 2.33 |
30f | CH3 |
| C23H18N4 |  > 30 ± 2.41 |  > 30 ± 2.69 |
30g | CH3 |
| C22H17N5 | 19.04 ± 2.56 | 17.32 ± 2.27 |
30h | CH3 |
| C24H19ClN4O |  > 30 ± 2.38 | 29.76 ± 2.64 |
30i | CH3 |
| C25H22N4O2 | 21.73 ± 2.46 | 18.35 ± 2.54 |
30j | CH3 |
| C31H22N4 |  > 30 ± 2.58 |  > 30 ± 2.62 |
Fluorouracil |  |  |  | 7.26 ± 2.30 | 5.23 ± 2.36 |