Table 16 IC50 values of the synthesized compounds (27a-j) Roopashree et al. [36]
From: Synthesis and therapeutic potential of imidazole containing compounds
Compounds | R-X-5 | R(6) | IC50(µM) ± SD |
|---|---|---|---|
27a | CH3I | CH3 |  > 50 |
27b | EtBr | Et |  > 50 |
27c | CH3(CH2)2CH2Br | CH3(CH2)2CH2 |  > 50 |
27d | CH3(CH2)5CH2Br | CH3(CH2)5CH2 | 25.3 ± 4.18 |
27e | 3-MeC6H4CH2Br | 3-MeC6H4CH2 | 30.2 ± 2.27 |
27f | 3-MeOC6H4CH2Br | 3-MeOC6H4CH2 |  > 50 |
27g | 4-ClC6H4CH2Br | 4-ClC6H4CH2 |  > 50 |
27h | 3,4-Cl2C6H3CH2Br | 3,4-Cl2C6H3CH2 | 31.9 ± 4.77 |
27i | 4-FC6H4CH2Br | 4-FC6H4CH2 | 30.0 ± 5.12 |
27j | C6H5CH2Br | C6H5CH2 |  > 50 |
Sorafenib |  |  | 4.1 ± 0.9 |