Fig. 7

Morphological and nuclear changes of MCF-7, tumor cells after treatment by chemical compounds 3, 7a, 7b, 7c and 7d compared with reference drug doxorubcin. Compounds induced various nuclear changes such as chromatin fragmented and condensation, nuclei condensation, as demonstrated by acridine orange/Ethidium bromide staining at 200×. Yellow arrows indicate live cell, pink arrows indicate early apoptotic Red arrows indicate necrotic and blue arrows indicate late apoptotic cells