Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

Table 2 Physicochemical properties of synthesized compounds

Compound	Mol. wt	Mol. formula	R_f value^a	(%) Yield^a	M.Pt (°C)
5a	385.44	C₁₉H₁₉N₃O₄S	0.67	75.4	234–235
5b	417.44	C₁₉H₁₉N₃O₆S	0.65	73.8	255–256
7	395.47	C₂₁H₂₁N₃O₃S	0.62	76.4	210–211
9a	356.37	C₁₉H₂₀N₂O₅	0.59	73.5	230–231
9b	372.44	C₁₉H₂₀N₂O₄S	0.74	72.8	210–211
11	341.36	C₁₈H₁₉N₃O₄	0.69	74.1	204–205
13a	314.33	C₁₈H₁₈O₅	0.70	73.8	199–200
13b	284.31	C₁₇H₁₆O₄	0.75	69.3	178–179
13c	284.31	C₁₇H₁₆O₄	0.83	73.7	157–159
13d	300.37	C₁₇H₁₆O₃S	0.84	75.9	182–184
16	340.37	C₂₀H₂₀O₅	0.67	69.9	120–122
17	294.34	C₁₉H₁₈O₃	0.79	72.4	178–179