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Table 1 Natural phenols evaluated for MAO inhibition and animal behavioral studies

From: Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

Natural phenols Structure of MAO inhibitors IC50 values of rat MAO-A (µM) IC50 values of rat MAO-B (µM) Animal specie Behavioral test Observations
Eugenol 5.34 ± 0.065 24.04 ± 1.32 Wistar rats FST Controls: negative and positive (ketamine)
Methyl-eugenol 7.12 ± 0.46 43.23 ± 0.054 Swiss albino rats (male and female) FST Controls: negative and positive (imipramine)
Menthol 23.11 ± 0.35 37.42 ± 0.76 ICR mouse FST Controls: negative and positive (fluoxetine)
Vanillin 17.88 ± 0.16 45.34 ± 0.09 Swiss mouse FST Controls: negative and positive (imipramine) The treatment reduced the spontaneous locomotion
Carvacrol 15.55 ± 0.49 23.42 ± 0.04 ICR mouse FST Controls: negative and positive (milnacipran)