Table 1 Natural phenols evaluated for MAO inhibition and animal behavioral studies
Natural phenols | Structure of MAO inhibitors | IC50 values of rat MAO-A (µM) | IC50 values of rat MAO-B (µM) | Animal specie | Behavioral test | Observations |
|---|---|---|---|---|---|---|
Eugenol |
| 5.34 ± 0.065 | 24.04 ± 1.32 | Wistar rats | FST | Controls: negative and positive (ketamine) |
Methyl-eugenol |
| 7.12 ± 0.46 | 43.23 ± 0.054 | Swiss albino rats (male and female) | FST | Controls: negative and positive (imipramine) |
Menthol |
| 23.11 ± 0.35 | 37.42 ± 0.76 | ICR mouse | FST | Controls: negative and positive (fluoxetine) |
Vanillin |
| 17.88 ± 0.16 | 45.34 ± 0.09 | Swiss mouse | FST | Controls: negative and positive (imipramine) The treatment reduced the spontaneous locomotion |
Carvacrol |
| 15.55 ± 0.49 | 23.42 ± 0.04 | ICR mouse | FST | Controls: negative and positive (milnacipran) |
