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Table 1 Analytical performance data for the determination of the studied drugs by the proposed methods

From: Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

Parameter 3rd Derivative method HPLC method
CTZ PPA NMS CTZ PPA NMS
Linearity range (µg/mL) 8–90 20–100 20–200 5–40 10–100 10–120
Intercept (a) 0.006 −0.028 −0.036 1.3 × 104 4.926 × 105 −7.217 × 104
Slope (b) 0.001 0.002 0.002 4.2399 × 104 3.1 × 104 9.343 × 104
Correlation coefficient (r) 0.9999 0.9999 0.9999 0.9999 0.9998 0.9999
S.D. of residuals (Sy/x) 5.061 × 10−4 1.146 × 10−3 1.169 × 10−3 5.015 × 103 1.912 × 104 6.67 × 104
S.D. of intercept (Sa) 3.371 × 10−4 1.16 × 10−3 1.143 × 10−3 3.21 × 103 1.377 × 104 4.908 × 104
S.D. of slope (Sb) 6.828 × 10−6 1.794 × 10−5 9.583 × 10−6 1.667 × 102 2.723 × 102 7.00 × 102
S.D. 0.94 1.51 1.28 0.44 1.49 1.10
% RSDa 0.95 1.53 1.29 0.44 1.49 1.10
% Errorb 0.39 0.86 0.53 0.18 0.61 0.45
LOD (µg/mL)c 1.10 1.90 1.90 0.25 1.47 1.70
LOQ (µg/mL)d 3.40 5.80 5.50 0.76 4.40 5.25
  1. aPercentage relative standard deviation
  2. bPercentage relative error
  3. cLimit of detection
  4. dLimit of quantitation