CELLmicrocosmos is an approach to develop tools for the generation of virtual cell environments. The CELLmicrocosmos 2 project deals with the computational generation of three-dimensional cell membranes. Biological membranes consist mainly of lipids and proteins. The Protein Data Bank  and the HIC-UP database  represent a large number of three-dimensional protein and lipid structures, which have been extracted from biological membranes. Other databases contain information about the membrane-type-specific localization of proteins. There exist various approaches of utilizing these models for the computation of membranes.