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Table 1 Some of the reported analytical methods for the determination of IS

From: Determination of indoxyl sulfate by spectrofluorimetric method in human plasma through extraction with deep eutectic solvent

Analytical method

Sample matrix

Linear range (µg/mL)

Ref.

LC–MS/MS

Human and animals’ plasma

0.1–100

[53]

LC–MS/MS

Human serum

0.5–10

[65]

LC–MS/MS

Human urine

0.1-106.5

[54]

LC–MS/MS

Human saliva

1500-200000

[56]

LC–MS/MS

Human serum, urine, and cell culture

1.06–8.52

[66]

LC-ESI-MS/MS

Human plasma

0.01-10

[67]

LC–MS/MS

Human serum and gastric juice

0.02–4.26

[61]

UHPLC–MS/MS

Human urine, plasma, and serum

0.019–9.860

[68]

Electrochemical

Rat serum

0.02–0.08

[50]

Spectrofluorimetry

Human plasma

2.5–40

[27]

Spectrophotometry

Human serum

1.59–20.2

[59]

  1. LC-MS/MS: Liquid Chromatography with tandem mass spectrometry, UPLC–MS/MS: Ultra Performance Liquid Chromatography with tandem mass spectrometry, LC-ESI-MS/MS: Liquid Chromatography Electrospray Ionization Tandem Mass spectrometry