Comp | R1 | R2 | R3 | AChE IC50 (µM) | BChE IC50 (µM) |
---|---|---|---|---|---|
8a | Methyl | H | 2-oxypropyl-isoindolinedione | 0.11 ± 0.05 | 30.2 ± 2.8 |
8b | Ethyl | H | 2-oxypropyl-isoindolinedione | 0.18 ± 0.01 | 26.8 ± 0.8 |
8c | Ethyl | 5-NO2 | 2-oxypropyl-isoindolinedione | 0.16 ± 0.04 | 21.8 ± 1.3 |
8d | Ethyl | H | 3-oxypropyl-isoindolinedione | 0.16 ± 0.03 | 11.8 ± 0.5 |
8e | Ethyl | 4-OCH3 | 3-oxypropyl-isoindolinedione | 0.21 ± 0.03 | 14.7 ± 0.2 |
8f | Methyl | H | 4-oxypropyl-isoindolinedione | 0.32 ± 0.02 | 15.7 ± 1.2 |
8g | Ethyl | H | 4-oxypropyl-isoindolinedione | 0.86 ± 0.02 | 5.7 ± 0.2 |
8h | Ethyl | 3-OCH3 | 4-oxypropyl-isoindolinedione | 0.17 ± 0.06 | 13.2 ± 1.4 |
Donepezila | – | – | – | 0.023 ± 0.02 | 7.2 ± 0.1 |