Skip to main content

Table 4 Predicted physico-chemical and absorption activity of compound 4k, 4l and kojic acid

From: Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations

Compound

Mw

LogP

Log Sa

Log Caco-2b

%HIAc

4k

356

1.96

− 3.394

0.97

94.3

4l

394.16

3.0

− 3.823

0.259

90.671

Kojic acid

142.1

− 0.162

− 1.69

0.64

88

  1. aPredicted aqueous solubility in mol L−1 (− 6.5 to 0.5) (QPlogS > − 5.7)
  2. bPredicted Caco-2 cell permeability of a given compound is given as the log Papp in 10−6 cm/s (high Caco-2 permeability has LogCaco-2 > 0.9)
  3. cPercent of human intestinal absorption, (< 30% is poor and > 30% is high)
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us