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Table 1 Tyrosinase inhibitory activity of nitrophenylpiperazine

From: Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations

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Entry

R

% Inhibition at 100 μMa

IC50 ± SDa (μM)

4a

Phenyl

35.8 ± 3.24

174.71 ± 0.68

4b

2-Bromophenyl

20.6 ± 2.58

> 200

4c

2,4-Dichlorophenyl

27.9 ± 3.09

> 200

4d

4-Nitrophenyl

28.3 ± 2.89

203.23 ± 1.16

4e

3-Nitrophenyl

24.9 ± 2.81

> 200

4f

2-Chloro-4-nitrophenyl

35.1 ± 2.25

> 200

4g

4-Methoxyphenyl

30.0 ± 4.04

> 200

4h

2,3-Dimethoxybenzoate

26.9 ± 3.55

200.88 ± 1.32

4i

Benzyl

39.4 ± 4.18

184.24 ± 0.88

4j

Vinylbenzene

23.1 ± 3.60

> 200

4k

3-Pyridine

54.3 ± 4.58

82.68 ± 1.16

4l

2-Indole

66.6 ± 4.12

72.55 ± 0.49

4m

5-Nitrofuran

43.7 ± 3.18

175.28 ± 0.24

Kojic acidb

–

–

27.56 ± 1.27

  1. aSD (standard deviation)
  2. bPositive control
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BMC Chemistry

ISSN: 2661-801X

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