Fig. 3

The four key signaling pathways in P. falciparum according to the presented PPI networking. Red nodes represent the ubiquitin–proteasome system in P. falciparum; violet nodes exemplify the glycerophospholipid metabolism in P. falciparum; (iii) DNA replication in P. falciparum; and (iv) intracellular anatomical structure in P. falciparum. Blue arrows highlight the proteins predicted as probable targets for limonin (2) investigated in the presented study. The thickness of the lines (i.e., edges) represents the degree of confidence (i.e., the strength of data support)