From: N′-(Furan-2-ylmethylene)-2-hydroxybenzohydrazide and its metal complexes: synthesis, spectroscopic investigations, DFT calculations and cytotoxicity profiling
Compound
In vitro cytotoxicity IC50 (µM)*
HePG-2
HCT-116
Doxorubicin
4.50 ± 0.2
5.23 ± 0.3
H2L
30.72 ± 2.2
35.40 ± 2.2
Cu(II)
82.63 ± 4.2
> 100
Co(II)
93.56 ± 4.7
89.01 ± 4.5
Ni(II)
41.47 ± 2.6
39.19 ± 2.4
Zn(II)
32.83 ± 2.3
37.27 ± 2.4