Table 4 Summary of the stability of zanubrutinib in rat plasma under different storage conditions (n = 6)
Analyte | Concentration (ng/mL) | Room temperature | 4 °C | Three freeze‒thaw | -80 °C | ||||
|---|---|---|---|---|---|---|---|---|---|
RE(%) | RSD(%) | RE(%) | RSD(%) | RE(%) | RSD(%) | RE(%) | RSD(%) | ||
Zanubrutinib | 2 | -0.2 | 6.1 | 1.3 | 5.0 | -1.8 | 4.1 | 2.5 | 5.2 |
40 | -1.4 | 4.1 | 1.4 | 7.1 | 2.6 | 4.0 | 1.5 | 10.3 | |
800 | -2.3 | 5.7 | 1.0 | 5.1 | -0.4 | 6.5 | 4.0 | 4.7 | |