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Table 2 Cytotoxicity of composite and compound 5 on vero normal and Cancerous MCF7 cell lines

From: Synthetic strategy towards novel composite based on substituted pyrido[2,1-b][1,3,4]oxadiazine-dialdehyde chitosan conjugate with antimicrobial and anticancer activities

ID

Conc

µg/ml

VERO

MCF7

Viability %

IC50 (µg/ml)

Toxicity %

IC50

(µg/ml)

Composite

1000

5.2 ± 0.55

472

97.04 ± 1.4

238

500

48.36 ± 2.8

72 ± 1.3

250

99.32 ± 0.3

51 ± 0.7

125

99.45 ± 0.3

21 ± 1.0

62.5

99.50 ± 0.4

11 ± 1.2

31.25

99.72 ± 0.3

3 ± 0.01

Compound 5

1000

3.39 ± 0.55

419

96.3 ± 0.8

405

500

38.90 ± 1.2

57 ± 0.55

250

97.41 ± 1.0

14.16 ± 1.4

125

99.09 ± 0.5

2.052 ± 0.4

62.5

99.41 ± 0.4

1.45 ± 0.2

31.25

99.41 ± 0.3

0.05 ± 0.5