Table 1 Cytotoxicity of the synthesized derivatives against MCF-7, MBA-MB-231 and MCF-10A cells

6f

23.1 ± 0.94

 ≥ 50

NT

6a

18.6 ± 0.69

19.8 ± 0.74

NT

6 h

17.3 ± 0.31

21.3 ± 0.64

NT

7a

 ≥ 50

26.5 ± 0.79

NT

7c

12.4 ± 0.34

 ≥ 50

NT

8a

31.2 ± 1.01

1.34 ± 0.13

NT

10a

 ≥ 50

6.4 ± 0.18

NT

10f

15.4 ± 0.28

8.6 ± 0.1

NT

10h

16.4 ± 0.31

2.3 ± 0.1

NT

11a

11.3 ± 0.29

7.2 ± 0.3

NT

11d

2.1 ± 0.01

0.92 ± 0.01

39.4 ± 1.8

12c

1.4 ± 0.05

1.89 ± 0.04

43.6 ± 1.9

12d

1.9 ± 0.01

0.57 ± 0.09

41.6 ± 1.8

Erlotinib

1.32 ± 0.04

1.02 ± 0.1

30.9 ± 1.8