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Fig. 5 | BMC Chemistry

Fig. 5

From: Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies

Fig. 5

Flow cytometry analysis for apoptosis/necrosis assessment in the untreated and 12d-treated MDA-MB-231 cells with the IC50 value of 0.57 μM for 48 h A Cytogram for Annexin V/PI staining. Quadrant charts show Q1 (necrotic cells, AV−/PI +), Q2 (late apoptotic cells, AV + /PI +), Q3 (normal cells, AV−/PI−), Q4 (early apoptotic cells, AV + /PI−). B Bar representation with cell percentage at each stage. Values are expressed as Mean ± SD of three independent trials “*(P ≤ 0.05), and **(P ≤ 0.001) are significantly different using the un-paired test in GraphPad prism”

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BMC Chemistry

ISSN: 2661-801X

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