Fig. 4

PCA analysis output from PCM. The function PCA was used to analyze the binding site amino acid descriptors (represented by 5 Z-scales). The first two principal components (PCs) accounted for over 76% of the variance, suggesting that the data primarily exhibits two main sources of variability. The LDHs can be observed to cluster into two distinct groups, corresponding to the isoenzymes LDHA and LDHB