Druglikeness/ADME/Ta | Compound | ||
---|---|---|---|
Acarbose | 11d | 11n | |
Rule of five | Violated | Suitable | Suitable |
Caco2 | 9.44448 | 3.03438 | 18.8466 |
HIA | 0.000000 | 91.952780 | 94.030638 |
BBB | 0.0271005 | 0.272919 | 0.411249 |
Skin permeability | − 5.17615 | − 3.52204 | − 3.34921 |
Ames test | Mutagen | Mutagen | Non-mutagen |
Carcino mouse | Positive | Positive | Negative |
Carcino rat | Negative | Negative | Positive |
hERG inhibition | Ambiguous | High risk | High risk |