From: In-silico engineering of RNA nanoplatforms to promote the diabetic wound healing
Parameter | Carrier | miRNA Antisense | SiRNA | ||||
1 | 2 | 3 | 4 | 5 | 6 | ||
VDW Energy (KJ/mol) | PLGA | -1201.15 | -952.161 | -1114.46 | -811.154 | -703.456 | -759.564 |
PEI | -801.744 | -603.567 | -704.415 | -484.188 | -440.485 | -451.745 | |
Chitosan | -425.654 | -302.485 | -397.561 | -156.546 | -108.584 | -146.474 | |
Electrostatics Energy (KJ/mol) | PLGA | -1.465 | -1.158 | -1.164 | -0.985 | -1.007 | -0.752 |
PEI | -7.465 | -3.594 | -6.654 | -1.176 | -2.841 | -1.054 | |
Chitosan | 170.251 | 128.214 | 164.214 | 77.547 | 83.147 | 54.173 | |
Total Energy (KJ/mol) | PLGA | -1202.62 | -953.319 | -1115.62 | -812.139 | -704.463 | -760.316 |
PEI | -809.209 | -607.161 | -711.069 | -485.364 | -443.326 | -452.799 | |
Chitosan | -255.403 | -174.271 | -233.347 | -78.999 | -25.437 | -92.301 | |
Gyrate radius (Initial-Final) (nm) | PLGA | 2.154 | 2.048 | 2.117 | 1.945 | 1.744 | 1.872 |
PEI | 1.844 | 1.485 | 1.737 | 0.907 | 0.732 | 0.841 | |
Chitosan | 0.471 | 0.257 | 0.343 | 0.097 | 0.047 | 0.14 | |
SASA (nm^2) | PLGA | 408.416 | 397.465 | 404.489 | 370.214 | 364.45 | 367.312 |
PEI | 350.215 | 339.764 | 347.526 | 307.774 | 298.117 | 301.731 | |
Chitosan | 284.247 | 269.564 | 274.337 | 209.15 | 204.563 | 218.416 |