Quantitative analysis of two COVID-19 antiviral agents, favipiravir and remdesivir, in spiked human plasma using spectrophotometric methods; greenness evaluation

Table 4 Bioanalytical validation parameters for quantitative analysis of FPV and RDV by the proposed methods

Parameters	RD		¹DD
Parameters	FPV	RDV	FPV	RDV
LLOQ (µg/mL)	1.5	1.4	1.5	1.4
Linearity range (µg/mL)	1.5–24	1.4–24	1.5–24	1.4–24
Accuracy (%R)^a	95.74	96.53	96.89	95.02
Repeatability precision (RSD)^b	1.567	1.897	1.418	1.658
Intermediate precision (RSD)^b	1.774	2.001	1.704	1.911
Matrix effect (Mean ± RSD)	96.30 ± 1.720	95.14 ± 1.936	96.25 ± 1.340	95.81 ± 1.437

^a The mean percentage recovery of tripicate determination of four quality control samples
^b RSD of tripicate determination of four quality control samples

ISSN: 2661-801X