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Table 3 Quantitative determination of FPV and RDV in pharmaceutical preparations using the proposed methods, as well as the results of using the standard addition technique, with statistical comparison to the reported methods

From: Quantitative analysis of two COVID-19 antiviral agents, favipiravir and remdesivir, in spiked human plasma using spectrophotometric methods; greenness evaluation

Recovery ± RSD

FPV

RDV

Method

RD

1DD

Reported method [17]

Method

RD

1DD

Reported method [37]

Avipiravir tablets a

99.46 ± 0.765

100.23± 1.099

100.03 ± 1.169

Remdesivir- vial a

99.51 ± 0.658

100.20 ± 1.040

100.14 ± 1.319

Standard addition b

100.55 ± 0.986

100.12 ± 0.887

 

Standard addition b

100.98 ± 1.058

100.42 ± 0.974

 

t-Test (2.306)c

0.905

0.869

 

t-Test (2.306)c

0.120

0.085

 

F-test (6.388)c

2.364

3.191

 

F-test (6.388)c

1.440

1.607

 
  1. aAverage of five determinations
  2. bAverage of three determinations
  3. c The values in parentheses are tabulated values of t and F at P = 0.05