Table 1 MIC of synthesized 12a-lcompounds (μg/ml) against gram-positive and gram-negative bacterial strains
Compound | Gram positive bacteria | Gram negative bacteria | ||
|---|---|---|---|---|
S. aureus | B. subtilis | P. aeruginosa | E. coli | |
MTCC 96 | MTCC 441 | MTCC 424 | MTCC 443 | |
12a | 6.7 ± 0.06 | 6.7 ± 0.06 | 9.5 ± 0.06 | 10.0 ± 0.08 |
12b | 7.2 ± 0.05 | 6.1 ± 0.08 | 9.8 ± 0.03 | 10.0 ± 0.08 |
12c | NA | NA | NA | NA |
12d | NA | NA | NA | NA |
12e | 4.8 ± 0.03 | 6.2 ± 0.03 | 9.8 ± 0.03 | 10.0 ± 0.06 |
12f | 5.1 ± 0.08 | 6.2 ± 0.03 | 8.7 ± 0.08 | 10.0 ± 0.06 |
12 g | 8.0 ± 0.03 | 7.2 ± 0.05 | 9.8 ± 0.03 | 10.0 ± 0.06 |
12 h | 7.2 ± 0.05 | 8.0 ± 0.03 | 9.5 ± 0.06 | 10.0 ± 0.08 |
12i | 9.8 ± 0.03 | 7.2 ± 0.05 | 9.8 ± 0.03 |  > 50 |
12j | 8.7 ± 0.08 | 8.0 ± 0.03 | 10.0 ± 0.06 |  > 25 |
12 k | 4.1 ± 0.03 | 6.2 ± 0.03 | 9.5 ± 0.06 |  > 25 |
12 l | 9.5 ± 0.06 | 6.2 ± 0.03 | 9.5 ± 0.06 |  > 50 |
Novobiocin | 3.9 ± 0.03 | NT | NT | NT |
Ampicillin | 10.0 ± 0.08 | 10.0 ± 0.06 | 10.0 ± 0.08 | 3.9 ± 0.03 |