Parameters | 2 | 3 | 4 | 5 | 8 | 9 | 10 | 11 |
---|---|---|---|---|---|---|---|---|
AMES toxicity | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Max. tolerated dose (human) | 0.373 | 0.244 | 0.214 | 0.237 | 0.421 | 0.331 | 0.063 | 0.505 |
hERG I inhibitor | No | No | No | No | No | No | No | No |
hERG II inhibitor | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Oral Rat Acute Toxicity (LD50 ) | 2.392 | 2.053 | 2.024 | 2.038 | 2.158 | 2.242 | 2.158 | 2.453 |
Oral Rat Chronic Toxicity (LOAEL) | 1.75 | 1.655 | 1.358 | 1.608 | 1.634 | 1.467 | 1.081 | 0.224 |
Hepatotoxicity | Yes | Yes | Yes | Yes | Yes | Yes | No | Yes |
Skin Sensitisation | No | No | No | No | No | No | No | No |
Tetrahymena pyriformis toxiciity | 0.638 | 0.323 | 0.306 | 0.327 | 0.34 | 0.335 | 0.447 | 0.288 |
Minnow toxicity | 0.389 | − 0.142 | − 0.078 | 0.076 | − 2.991 | − 3.226 | 2.08 | − 5.514 |