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Table 1 IC50 (µM) of carbazole derivatives on various cell lines

From: Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents

Cell line/ code

IC50 (µM)

2

3

4

8

9

10

11

5-FU

B16F1

Ni

Ni

Ni

107.65±

40.22 ± 1.25

Ni

118.30 ± 1.08

83.43 ± 2.50

Colo205

Ni

Ni

Ni

Ni

252.01 ± 2.58

173.304 ± 2.41

Ni

12.04 ± 1.87

HepG2

Ni

Ni

Ni

37.62 ± 2.02

107.07 ± 2.42

7.686 ± 1.07

18.91 ± 1.26

3.85 ± 0.75

CaCo-2

187.23 ± 2.47

71.23 ± 2.04

46.83 ± 1.58

95.37 ± 1.08

86.35 ± 1.015

73.80 ± 2.11

43.7 ± 2.33

7.08 ± 0.54

HeLa

Ni

Ni

210.11 ± 2.19

64.94 ± 1.85

7.59 ± 0.89

10.09 ± 0.78

17.17 ± 1.02

1.26 ± 0.27

Hep3B

Ni

Ni

Ni

152.85 ± 1.49

171.86 ± 2.07

38.335 ± 2.11

22.16 ± 1.75

23.44 ± 1.71

MCF-7

Ni

Ni

79.70 ± 2.07

19.18 ± 1.05

18.16 ± 1.45

18.41 ± 0.29

6.44 ± 1.25

1.82 ± 0.88

LX-2

Ni

Ni

Ni

90.09 ± 2.15

4.67 ± 1.80

Ni

2.87 ± 0.57

15.92 ± 0.95

  1. Bold values indicates to the most potent compound and cell lines
  2. Ni no inhibition or the IC50 values >250 µM
  3. P-value ≤ 0.05
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BMC Chemistry

ISSN: 2661-801X

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