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Table 10 Calculation of penalty points for the proposed methods

From: Green quality by design HPLC approach for the simultaneous determination of Bilastine and Montelukast

Reagents

Amount

Signal word

No of pectograms

Sub-total PP

 1. MeOH

10–100 mL

Danger = 2

3.00

6.00

 2. ACN

 < 10 mL = 1

Danger = 2

1.00

2.00

 3. Pot. Dihyd. Ph

 < 10 mL = 1

0

0.00

0.00

 4. Phosphoric.a

 < 10 mL = 1

Danger = 2

1.00

2.00

 5. TEA

 < 10 mL = 1

Danger = 2

1.00

2.00

Total PP for reagents

12.00

 Imstrument

HPLC = 2

2.00

 Occupational hazard

Not emit vap and gases = 0

0.00

 Waste

1–10 mL = 2

2.00

Total PP for instruments

4.00

 Total PP

16.00

 Analytical Eco-Scale total score:

84.00