Table 2 Antimicrobial activity of the newly synthesized thiophene-2-carboxamide derivatives using various bacterial strains
Compound | E. coli | P.aeruginosa | S. aureus | B. subtilis |
|---|---|---|---|---|
3a | 5 (20.0) | 11 (47.8) | 10 (41.7) | 13 (56.5) |
3b | 13 (52.0) | 18 (78.3) | 17 (70.8) | 18 (78.3) |
3c | 9 (36.0) | 12 (52.2) | 13 (54.2) | 16 (69.6) |
5a | NA (––) | 7 (30.4) | 6 (25.0) | 8 (34.8) |
5b | 4 (16.0) | 10 (43.5) | 9 (37.5) | 11 (47.8) |
5c | NA(––) | 3 (13.0) | 4 (16.7) | 6 (26.1) |
7a | 12 (48.0) | 15 (65.2) | 16 (66.7) | 17 (73.9) |
7b | 16 (64.0) | 20 (86.9) | 20 (83.3) | 19 (82.6) |
7c | 10 (40.0) | 17 (73.9) | 16 (66.7) | 17 (73.9) |
Ampicillin | 25 | 23 | 24 | 23 |