Application of Box-Behnken experimental design and response surface methodology for selecting the optimum RP-HPLC conditions for the simultaneous determination of methocarbamol, indomethacin and betamethasone in their pharmaceutical dosage form

Table 4 System suitability tests of the proposed RP-HPLC method for the simultaneous determination of MTL, IND and BET

Parameter	MTL		IND		BET	Reference value
Number of theoretical plates (N)	8821		8990		12,010	The higher the value, the more efficient the column is
Resolution factor (R)		8.54		7.52		> 2
Tailing factor (T)	0.76		0.72		0.88	≤ 2
Capacity factor (K´)	2.100		3.162		5.170	1–10
Selectivity factor (α)		1.45		1.35		≥ 1
% R.S.D. of t_R of 6 injections	0.77		0.50		0.79

ISSN: 2661-801X