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Table 6 Statistical comparison of the results obtained by the proposed HPLC method and reported method for the determination of ETO and PCM

From: Validated HPLC–PDA methodology utilized for simultaneous determination of Etoricoxib and Paracetamol in the presence of Paracetamol toxic impurities

Parameter

HPLC method

Reported HPLC method a

ETO

PCM

ETO

PCM

Mean

100.21

100.58

99.98

99.89

SD

0.973

0.858

0.992

1.102

Variance

0.947

0.736

0.984

1.214

n

9

9

9

9

Student's t-test b

(2.120)

0.492

1.479

  

F value b

(3.44)

1.040

1.650

  
  1. a HPLC method using a C18 column as the stationary phase and a mixture consisting of methanol: water) in ratio (70:30 v/v as a mobile phase. The mobile phase was pumped at a flowrate of 1.0 mL/min. UV detection was carried out at 235.0 nm [49]
  2. b The values in parentheses are the corresponding tabulated two-tailed values at P = 0.05
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BMC Chemistry

ISSN: 2661-801X

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