Table 1 Reaction conditions for the synthesis of Anilinomethylenemalonate (1)
Entry | Solvent | Heating method | Temperature/Time | % Yield |
|---|---|---|---|---|
1 | MeOH | Microwave | 120 ℃ for 30 min | 56 |
2 | MeOH | Conventional | Reflux, 4Â h | 78 |
3 | MeOH | Conventional | Reflux, 8Â h | 93 |
4 | EtOH | Microwave | 140 ℃ for 30 min | 32 |
5 | EtOH | Conventional | Reflux, 4Â h | 63 |
6 | EtOH | Conventional | Reflux, 8Â h | 84 |
7 | DCM | Conventional | Reflux, 4Â h | 20 |
8 | DCM | Conventional | 8Â h | 32 |