Synthesis, biological evaluation and molecular docking of new triphenylamine-linked pyridine, thiazole and pyrazole analogues as anticancer agents

Table 2 Important computed physicochemical properties of the most potent compounds 4b, 4c, and 6c

compounds	MW	log P	HBD	HBA	TPSA (A²)	n-RB	Lipinskiviolation
4b	493.56	3.83	1	3	98.84	5	0
4c	509.56	3.30	1	4	108.07	6	1
6c	604.72	3.30	1	3	106.37	8	1
Lipinski/Veber’s Rules	≤ 500	≤ 5	≤ 5	≤ 10	≤ 140	≤ 10	≤ 1

MW Molecular weight, LogP Logarithm of partition coefficient between n-octanol and water, HBD Hydrogen-bonded donor, HBA Hydrogen-bonded acceptor, TPSA Topological polar surface area, n-RB Number of rotatable bonds

ISSN: 2661-801X