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Table 6 Percentage of HepG2 cells in each state after treatment with compound 4c at 48 h

From: Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Concentration

Vital (%) An −/PI −

Early apoptosis (%) An +/PI −

Late apoptosis (%) An +/PI +

Necrosis (%) An −/PI +

2 µM

92.67 ± 1.94

4.93 ± 1.75

0.95 ± 0.28

1.45 ± 0.10

5 µM

85.05 ± 1.71*

11.60 ± 1.51*

1.83 ± 0. 03*

1.31 ± 0.05

10 µM

81.77 ± 0.85**

15.37 ± 0.61**

1.71 ± 0.16*

1.14 ± 0.18

Control/vehicle

93.05 ± 0.80

4.79 ± 0.88

0.86 ± 0.09

1.30 ± 0.18

  1. The data presented are the mean ± SEM of three independent experiments. *p < 0.05, **p < 0.01 compared with control/vehicle
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BMC Chemistry

ISSN: 2661-801X

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