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Table 5 ANOVA results of the fractional factorial design (insignificant interaction effects were excluded)

From: Quality by design approach for development and validation of a RP-HPLC method for simultaneous estimation of xipamide and valsartan in human plasma

Item

Retention time (VAL) (min)

Resolution

F

p-value

F

p-value

A: pH

–

–

3.66

0.1041

B: % MeOH

75.19

 < 0.0001

82.35

0.0001

C: Flow rate

7.91

0.0260

–

–

D: Detection wavelength

–

–

–

–

E: Buffer conc

–

–

4.02

0.0919

Adjusted R2

0.9132

0.9110

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BMC Chemistry

ISSN: 2661-801X

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