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Table 2 Regression and validation data for quantitative analysis of ASP and OMZ by the proposed methods

From: Application of different quantitative analytical techniques for estimation of aspirin and omeprazole in pharmaceutical preparation

Parameters 1DD TLC densitometry
ASP OMZ ASP OMZ
Wavelength (nm) 237 295 272 272
Linearity range 20–140 µg/mL 4–20 µg/mL 10–50 ng/band 10–50 ng/band
Slope 0.0591 0.2693 478.27 974.66
Intercept 0.0392 0.0780 386.52 133.29
Coefficient of determination (r2) 0.9997 0.9999 0.9996 0.9999
LOD 6.183 µg/mL 1.129 µg/mL 3.026 ng/band 2.838 ng/band
LOQ 18.736 µg/mL 3.422 µg/mL 9.169 ng/band 8.597 ng/band
Accuracy (%R)a 98.72 100.24 100.38 98.75
Repeatability precision (RSD)b 0.621 0.521 0.732 0.528
Intermediate precision (RSD)b 0.425 0.670 0.798 0.882
  1. aAverage of 9 determinations (3 concentrations repeated 3 times)
  2. bRSD of 9 determinations (3 concentrations repeated 3 times)