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Table 2 Inhibition (IC50) of HCT116 and MCF-7 cell lines and inhibition of Aurora-A kinase by compounds P (1–21)

From: Design, synthesis, anticancer evaluation and docking studies of novel 2-(1-isonicotinoyl-3-phenyl-1H-pyrazol-4-yl)-3-phenylthiazolidin-4-one derivatives as Aurora-A kinase inhibitors

Comp

IC50 ± SD (µM)

HCT-116a

MCF-7a

Aurora- Ab

P-1

2.30 ± 0.14

4.40 ± 0.18

2.34 ± 0.36

P-2

3.52 ± 0.33

3.26 ± 0.31

3.57 ± 0.35

P-3

4.47 ± 0.45

4.49 ± 0.42

7.25 ± 0.80

P-4

1.35 ± 0.07

2.55 ± 0.07

1.33 ± 0.15

P-5

3.88 ± 0.16

4.01 ± 0.10

4.79 ± 0.83

P-6

0.37 ± 0.15

0.44 ± 0.06

0.18 ± 0.05

P-7

0.62 ± 0.03

0.88 ± 0.03

0.42 ± 0.12

P-8

5.35 ± 0.27

6.08 ± 0.24

7.32 ± 0.69

P-9

1.45 ± 0.18

1.62 ± 0.05

1.45 ± 0.05

P-10

0.78 ± 0.04

1.03 ± 0.11

0.65 ± 0.09

P-11

2.54 ± 0.20

2.53 ± 0.19

2.78 ± 0.14

P-12

4.06 ± 0.38

4.35 ± 0.47

5.59 ± 0.37

P-13

5.87 ± 0.42

8.21 ± 0.35

12.37 ± 0.85

P-14

4.08 ± 0.31

5.30 ± 0.62

5.52 ± 0.55

P-15

2.18 ± 0.15

2.34 ± 0.27

2.10 ± 0.13

P-16

2.01 ± 0.11

2.25 ± 0.25

2.10 ± 0.15

P-17

2.92 ± 0.26

3.24 ± 0.13

3.04 ± 0.48

P-18

1.52 ± 0.09

1.77 ± 0.15

1.62 ± 0.11

P-19

1.02 ± 0.12

1.21 ± 0.05

0.79 ± 0.07

P-20

0.42 ± 0.08

0.56 ± 0.06

0.22 ± 0.08

P-21

0.97 ± 0.10

1.10 ± 0.08

0.79 ± 0.07

VX-680 (Tozasertib)

0.30 ± 0.03

0.38 ± 0.02

0.13 ± 0.01

  1. aInhibition of growth of tumor cell lines
  2. bInhibition of Aurora-A kinase
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BMC Chemistry

ISSN: 2661-801X

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