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Table 1 Physicochemical data of 2-(1-isonicotinoyl-3-aryl-4,5-dihydro-1H-pyrazol-4-yl)-3-phenyl thiazolidin-4-one derivatives P (1–21)

From: Design, synthesis, anticancer evaluation and docking studies of novel 2-(1-isonicotinoyl-3-phenyl-1H-pyrazol-4-yl)-3-phenylthiazolidin-4-one derivatives as Aurora-A kinase inhibitors

Comp R R1 Mol. Wt Rf* Rf** Conventional synthesis Microwave-assisted synthesis Melting point (°C)
Reaction Time (hrs) % yield Microwave power (W) Reaction time (min) % yield
P-1 4-NO2 H 473 0.60 0.58 1.0 68.2 300 2 89.2 244–246
P-2 4-NO2 4-NO2 520 0.37 0.50 1.0 67.3 300 2 87.4 266–268
P-3 4-NO2 2-NO2 520 0.20 0.32 1.0 60.5 300 2 83.1 282–284
P-4 4-NO2 4-Cl 507 0.23 0.24 1.0 56.9 300 2 80.0 286–288
P-5 4-NO2 3-Cl 507 0.69 0.64 1.0 59.2 300 2 75.8 274–276
P-6 4-NO2 3-OCH3 503 0.71 0.67 1.0 61.2 300 2 72.6 262–264
P-7 4-NO2 2-OCH3 503 0.66 0.62 1.0 67.4 300 2 93.4 250–252
P-8 4-OCH3 H 456 0.55 0.63 1.0 73.7 300 2 82.5 300–302
P-9 4-OCH3 4-NO2 503 0.53 0.71 1.0 68.9 300 2 76.3 308–310
P-10 4-OCH3 2-NO2 503 0.47 0.65 1.0 56.4 300 2 64.7 322–324
P-11 4-OCH3 4-Cl 490 0.35 0.70 1.0 59.2 300 2 68.8 318–320
P-12 4-OCH3 3-Cl 490 0.48 0.58 1.0 61.6 300 2 72.4 338–340
P-13 4-OCH3 3-OCH3 486 0.63 0.64 1.0 66.8 300 2 76.6 320–322
P-14 4-OCH3 2-OCH3 486 0.32 0.59 1.0 73.9 300 2 84.3 336–338
P-15 4-Br H 504 0.70 0.65 1.0 66.8 300 2 84.7 256–258
P-16 4-Br 4-NO2 551 0.40 0.36 1.0 58.2 300 2 68.9 268–270
P-17 4-Br 2-NO2 551 0.21 0.35 1.0 61.2 300 2 72.0 252–254
P-18 4-Br 4-Cl 538 0.74 0.79 1.0 59.7 300 2 79.8 244–246
P-19 4-Br 3-Cl 538 0.70 0.74 1.0 64.2 300 2 72.3 248–250
P-20 4-Br 3-OCH3 535 0.60 0.65 1.0 61.3 300 2 83.2 252–254
P-21 4-Br 2-OCH3 535 0.28 0.32 1.0 58.4 300 2 69.1 260–262
  1. TLC Mobile phase: *n-hexane: ethylacetate (4:6), **Ethylacetate: n-hexane: methanol (3:6:1)