Scheme 1
General synthesis of 2-(1-isonicotinoyl-3-phenyl-1H-pyrazol-4-yl)-3-phenylthiazolidin-4-one derivatives P (1–21). Reagents and conditions: (i) ethanol, glacial acetic acid, Conv.- reflux 30–40 min, MW-2–3 min (ii) DMF/POCl3, Conv.-reflux, 4–5 h, MW-3–4 min (iii) Conv.-reflux, 1-2 h, MW-3–4 min (iv) thioglycollic acid/DMF, Anhyd. ZnCl2, Conv.-1 h, MW-3–4 min