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Table 1 In vitro antiplasmodial activity, cytotoxicity and selective index of N-acylhydrazone compounds AH1-AH7

From: Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives

Compounds IC50 ± SDa (µM)bP. falciparum LC50 ± SDa (µM)c WI-26VA4 SId
AH1 0.19 ± 0.10 100 ± 0.25 526.31
AH2 2.15 ± 0.09 100 ± 0.33 46.51
AH3 Not determined 100 ± 0.19 Not determined
AH4 0.09 ± 0.05 100 ± 0.21 1,111.11
AH5 0.07 ± 0.07 100 ± 0.23 1,428.57
AH6 Not determined 100 ± 0.17 Not determined
AH7 Not determined 100 ± 0.13 Not determined
Chloroquine 0.057 ± 0.14 100 ± 0.22 1754.38
Artemether  < 1.01 100 ± 0.18 99.01
  1. a SD: Mean and standard deviation (SD) of triplicate experiments
  2. b 50% Inhibitory concentration against a Plasmodium falciparum chloroquine resistant (W2) strain
  3. c 50% Cytotoxic concentration against human lung fibroblast cell line (WI-26VA4)
  4. d Selectivity index (SI) = IC50 (WI26VA4)/IC50 (P. falciparum)