Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives

BMC Chemistry

Table 1 In vitro antiplasmodial activity, cytotoxicity and selective index of N-acylhydrazone compounds AH1-AH7

Compounds	IC₅₀ ± SD^a (µM)^bP. falciparum	LC₅₀ ± SD^a (µM)^c WI-26VA4	SI^d
AH1	0.19 ± 0.10	100 ± 0.25	526.31
AH2	2.15 ± 0.09	100 ± 0.33	46.51
AH3	Not determined	100 ± 0.19	Not determined
AH4	0.09 ± 0.05	100 ± 0.21	1,111.11
AH5	0.07 ± 0.07	100 ± 0.23	1,428.57
AH6	Not determined	100 ± 0.17	Not determined
AH7	Not determined	100 ± 0.13	Not determined
Chloroquine	0.057 ± 0.14	100 ± 0.22	1754.38
Artemether	< 1.01	100 ± 0.18	99.01

^a SD: Mean and standard deviation (SD) of triplicate experiments
^b 50% Inhibitory concentration against a Plasmodium falciparum chloroquine resistant (W2) strain
^c 50% Cytotoxic concentration against human lung fibroblast cell line (WI-26VA4)
^d Selectivity index (SI) = IC₅₀ (WI26VA4)/IC₅₀ (P. falciparum)

ISSN: 2661-801X