Table 2 IC50 (µM) of phenyl-isoxazole–Carboxamide compounds (2a–2f) on various cell lines
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|---|---|---|---|---|---|---|
Code | 2a | 2b | 2c | 2d | 2e | 2f |
R | 2,5–OMe 4–Cl | 3–CF3 | 4-(2-methoxy phenoxy) | 4-SCH3 | 4–OCF3 | 4-(thiophen-2-yl) |
IC50 µM | ||||||
Cell line | 2a | 2b | 2c | 2d | 2e | 2f |
B16F1 | 29.72 ± 2.12 | 42.93 ± 1.55 | 21.13 ± 0.78 | 39.84 ± 1.45 | 0.079 ± 0.004 | 12.72 ± 1.01 |
Colo205 | 9.18 ± 0.88 | > 200 | 183.45 ± 2.05 | 216.38 ± 1.58 | > 200 | 75.40 ± 2.41 |
HepG2 | 7.55 ± 0.79 | 53.58 ± 2.04 | 120.02 ± 2.19 | 37.86 ± 2.07 | > 200 | 38.38 ± 1.07 |
CaCo-2 | 129.17 ± 2.47 | > 200 | > 200 | > 200 | > 200 | > 200 |
HeLa | 40.84 ± 1.25 | > 200 | > 200 | > 200 | > 200 | > 200 |
Hep3B | > 200 | > 200 | > 200 | > 200 | > 200 | 54.61 ± 2.11 |
MCF-7 | > 200 | > 200 | > 200 | > 200 | > 200 | > 200 |
Hek293t | 2.54 ± 1.40 | 147.58 ± 2.74 | 20.18 ± 1.32 | > 200 | 190.16 ± 2.67 | 7.91 ± 0.61 |
