Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (GO-Fe3O4–Ti(IV)): anticonvulsant evaluation and computational studies

Table 5 In silico ADME of the 2-(aryl or alkyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine derivatives

Entry	Absorption			Distribution
Entry	% HIA^a	In vitro Caco-2 cell permeability (nm s⁻¹)	In vitro Skin permeability((log Kp, cm h − 1)	% In vitro plasma protein bonding	%BBB^b
S₁	100	57.30	− 2.68	100	2.27
S₂	100	58.05	− 2.7	83.88	2.02
S₃	100	58.16	− 3.07	83.09	4.07
S₄	100	58.02	− 2.56	86.52	1.67
S₅	100	58.15	− 2.74	91.96	2.07
S₆	100	57.98	− 2.49	87.68	4.67
S₇	100	58.15	− 2.66	92.29	3.22
S₈	100	57.49	− 2.75	86.65	1.87
S₉	100	56.37	− 3.33	82.78	2.86
S₁₀	100	58.04	− 2.49	94.16	4.41
S₁₁	100	57.65	− 2.96	92.59	0.37
*Diazepam*	99.49	47.68	− 3.07	98.74	2.58

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