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Table 1 Optimization of the reaction conditions for the synthesis of S11

From: Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (GO-Fe3O4–Ti(IV)): anticonvulsant evaluation and computational studies

Entry Catalyst (g) Temp Solvent Time (min) Yield (%)
1 GO (0.04) 60 Solvent-free 35 30
2 GO-Fe3O4 (0.04) 60 Solvent-free 30 65
3 GO-Fe3O4-Ti (IV) (0.04) 60 Solvent-free 12 92
4 GO-Ti (IV) (0.04) 60 Solvent-free 40 85
5 GO-Fe3O4-Ti (IV) (0.04) 60 C2H5OH 23 85
6 GO-Fe3O4-Ti (IV) (0.04) 60 H2O 25 85
7 GO-Fe3O4-Ti (IV) (0.04) 60 CHCl3 25 48
8 GO-Fe3O4-Ti (IV) (0.04) 60 Solvent-free 12 92
9 GO-Fe3O4-Ti (IV) (0.04) Room temperature Solvent-free 50 70
10 GO-Fe3O4-Ti (IV) (0.04) 100 Solvent-free 12 92
11 GO-Fe3O4-Ti (IV) (0.01) 60 Solvent-free 40 67
12 GO-Fe3O4-Ti (IV) (0.02) 60 Solvent-free 45 85
13 GO-Fe3O4-Ti (IV) (0.03) 60 Solvent-free 20 90
14 GO-Fe3O4-Ti (IV) (0.05) 60 Solvent-free 12 92